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Ovarian Cancer PDX Models

The Crown Bioscience ovarian cancer patient-derived xenograft (PDX) collection consists of several models including a treatment resistant model. PDX models present a true representation of the human heterogeneity of gynecologic malignancies and provide the most accurate approach to predicting an agents efficacy prior to entering the clinic. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience’s HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
OV0243 Ovarian Cancer Papillary adenocarcinoma Pathology QC: Papillary adenocarcinoma (P4, P7). CLICK TO VIEW
OV0250 Ovarian Cancer Endometrioid adenocarcinoma Mixed adenocarcinoma of ovary. Endometrioid adenocarcinoma, grade III, invaded the uterine wall. CLICK TO VIEW
OV0273 Ovarian Cancer NA Embryonal carcinoma of right ovary. No malignant cells adjacent to right oviduct. IHC results: CD56(+/-),Syn(+/-),CK(+/-),CD117(+/-),AR(-), PLAP(-), CA1259(-). CLICK TO VIEW
OV0276 Ovarian Cancer ADC Mucinous adenocarcinoma of ovary (could not exclude Krukenberg's tumor). No malignant cells adjacent to oviduct and perimetrium. Regional LN: LN of abdominal aorta (2/2). CLICK TO VIEW
OV0589 Ovarian Cancer NA NA for clinical diagnosis info. Pathology QC: Papillary adenocarcinoma (Pa, P1) CLICK TO VIEW
OV1200 Ovarian Cancer ADC Adenocarcinoma of both ovary and oviduct, poorly to moderately differentiated. CLICK TO VIEW
OV1272 Ovarian Cancer cystadenoma Mucinous cystadenoma of bilateral ovary. The tumor of bilateral adnexa uteri forms irregular glandular structures and has an infiltrative growth pattern. IHC results: PR(-), ER(-), CK7(+), CK20(-), Villin(+). CLICK TO VIEW
OV1286 Ovarian Cancer ADC Adenocarcinoma of right ovary. CLICK TO VIEW
OV1327 Ovarian Cancer Serous papillary cystadenocarcinoma Papillary serous cystadenocarcinoma of right ovary. The tumor forms irregualar papillary glandular structures and has an infiltrative growth pattern. Columnar epithelial cells may be seen. The neoplastic cells invasive pelvic cavity and greater omentum. CLICK TO VIEW
OV1365 Ovarian Cancer ADC Mixed epithelial malignant tumor of left ovary, include serous adenocarcinoma, clear cell carcinoma and hepatoid adenocarcinoma. Tumor forms nest and papillary structures and has an infiltrative growth pattern. Regional LN: left obturator LN (1/6), left inguinal LN (0/3), left internal and external iliac (0/4), left common iliac LN (0/7), right common iliac LN (0/2), right internal and external iliac LN (0/5), right inguinal LN (0/4), right obturator LN (0/4). CLICK TO VIEW
OV1385 Ovarian Cancer Cystadenoma 1. Mucous cystadenocarcinoma of bilateral ovary. The tumor forms adenoid tubular and nest structures and has an infiltrative growth pattern. Malignant cells are viewed within bilateral fimbriae oviduct.Regional LN: LN of greater omentum (0/3). 2. Chronic appendicitis CLICK TO VIEW
OV13950 Ovarian Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
OV1396 Ovarian Cancer NA Poorly differentiated serous papillary carcinoma of bilateral oviduct and involving bilateral ovary. The tumor forms irregular papillary, solid forms and has an infiltrative growth pattern. Regional LN: LN of right abdominal aorta (3/4), left obturator LN (1/3), right obturator LN (2/3), left groin LN (2/2), left interna and external iliac LN (1/1), right common iliac (1/3), right gorin (0/3), left common iliac LN (0/4). CLICK TO VIEW
OV14654 Ovarian Cancer N/A N/A CLICK TO VIEW
OV14972 Ovarian Cancer NA Ovarian Carcinoma. Pathol comment: C/W REFERRING DIAGNOSIS. MICROSCOPIC FOCUS OF MALIGNANT TUMOR PRESENT IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
OV15013 Ovarian Cancer NA Metastatic serous papillary carconoma, PD. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 80% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
OV15398 Ovarian Cancer NA Ovarian Carcinoma. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 100% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
OV15612 Ovarian Cancer NA Ovarian Carcinoma. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 100% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. FOCAL TUMOR NECROSIS. APPROXIMATELY 70% MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREPARATION. CLICK TO VIEW
OV15631 Ovarian Cancer NA Ovarian Carcinoma. Pathol comment: MALIGNANT TUMOR CELLS PRESENT IN CELL BLOCK. APPROXIMATELY 90% MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREPARATION. C/W DIAGNOSIS. CLICK TO VIEW
OV1579 Ovarian Cancer NA Left ovary: moderately-poorly differentiated adenocarcinoma. CLICK TO VIEW
OV15841 Ovarian Cancer NA H/O ovarian carcinoma, RECURRENT UNDIFFERENTIATED CARCINOMA. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 80% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. APPROXIMATELY 80% MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREPARATION. CLICK TO VIEW
OV1658 Ovarian Cancer NA Small cell undifferentiated carcinoma CLICK TO VIEW
OV2015 Ovarian Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
OV2017 Ovarian Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
OV2018 Ovarian Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
OV2026 Ovarian Cancer NA Carcinosarcoma, NOS CLICK TO VIEW
OV2027 Ovarian Cancer Serous papillary cystadenocarcinoma Papillary serous cystadenocarcinoma CLICK TO VIEW
OV2029 Ovarian Cancer NA Mixed cell adenocarcinoma CLICK TO VIEW
OV2034 Ovarian Cancer Serous cystadenocarcinoma Serous cystadenocarcinoma, NOS CLICK TO VIEW
OV2423 Ovarian Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
OV2546 Ovarian Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
OV3355 Ovarian Cancer Serous adenocarcinoma Bilateral ovaries: poorly differentiated serous adenocarcinoma. One of one lymph node involved by malignant carcinoma (1/1). CLICK TO VIEW
OV3395 Ovarian Cancer Serous papillary cystadenocarcinoma Right ovary: serous papillary cystadenocarcinoma CLICK TO VIEW
OV3414 Ovarian Cancer Serous adenocarcinoma Pelvic cavity and right ovary: serous adenocarcinoma, moderately differentiated CLICK TO VIEW
OV3425 Ovarian Cancer Serous papillary cystadenocarcinoma Bilateral ovaries: serous papillary adenocarcinoma, moderately differentiated. The tumor infiltrated omentum majus and vermix. Six of nineteen lymph nodes involved by malignant carcinoma (6/19). CLICK TO VIEW
OV3596 Ovarian Cancer ADC Left ovay: poorly differentiated adenocarcinoma, tend to mucinous adenocarcinoma with endometrioid adenocarcinoma CLICK TO VIEW
OV3692 Ovarian Cancer Adenocarcinoma NA CLICK TO VIEW
OV3708 Ovarian Cancer Mucinous adenocarcinoma Right ovary and fallopian tube: moderately to poorly differentiated mucinous adenocarcinoma. CLICK TO VIEW
OV3756 Ovarian Cancer Serous adenocarcinoma Pelvic cavity: moderately differentiated serous adenocarcinoma, consider infiltrating or implanted ovarian serous adenocarcinoma on the basis of medical history CLICK TO VIEW
OV5287 Ovarian Cancer Ovarian (high grade) ADENOCARCINOMA, MUCINOUS. CLICK TO VIEW
OV5294 Ovarian Cancer mucinous adenocarcinoma ovarian carcinoma mucinous adenocarcinoma. Pathol comment: c/w diagnosis. approximately 60% of the tissue involved by malignant tumor in sections examined. malignant tumor cells present in cytospin prep. CLICK TO VIEW
OV5296 Ovarian Cancer cystadenocarcinoma ovarian carcinoma mucinous cystadenocarcinoma. Pathol comment: c/w referring diagnosis. malignant cell present in cell block and cytospin prep. CLICK TO VIEW
OV5297 Ovarian Cancer clear cell carcinoma ovarian carcinoma clear cell adenocarcinoma, high grade. Pathol comment: c/w diagnosis. approximately 70% of the tissue involved by malignant tumor in sections examined. 20% necrosis. approximately 80% malignant tumor cells present in cytospin preparation. CLICK TO VIEW
OV5298 Ovarian Cancer ADC ovarian carcinoma metastastic mucin producing adenocarcinoma. Pathol comment: approximately 80% of the tissue involved by malignant tumor in sections examined. consistent with mucinous adenocarcinoma. approximately 70% malignant tumor cells present in cytospin preparation. CLICK TO VIEW
OV5304 Ovarian Cancer serous carcinoma (high grade) carcinomatosis, ovarian malignant tumor high grade, grade 3, serous carcinoma extensively involving the omentum, splenic capsule, and preipancreatic tissue CLICK TO VIEW
OV5308 Ovarian Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
OV5390 Ovarian Cancer NA Ovarian Cancer CLICK TO VIEW
OV5391 Ovarian Cancer N/A Ovarian cancer patient-derived xenograft (PDX) model OV5391. Cancer Type: Ovarian Cancer, Metastatic Serous Carcinoma. Cancer Sub-type: Serous Carcinoma. This model is from the same patient as OV5392. CLICK TO VIEW
OV5392 Ovarian Cancer Serous Carcinoma Ovarian cancer patient-derived xenograft (PDX) model OV5392. Cancer Type: Ovarian Cancer, Metastatic Serous Carcinoma. Cancer Sub-type: Serous Carcinoma. This model is from the same patient as OV5391. CLICK TO VIEW
OV5397 Ovarian Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
OV5398 Ovarian Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
OV6308 Ovarian Cancer Serous Adenocarcinoma Bilateral ovaries: serous adenocarcinoma, high-grade CLICK TO VIEW
OV9399 Ovarian Cancer NA NA CLICK TO VIEW
OV9408 Ovarian Cancer NA metstatic adenocarcinoma CLICK TO VIEW
OV9413 Ovarian Cancer NA NA CLICK TO VIEW
OV9419 Ovarian Cancer Serous carcinoma NA CLICK TO VIEW
OV9421 Ovarian Cancer Adenocarcinoma NA CLICK TO VIEW
OV9422 Ovarian Cancer Mixed epithelial carcinoma NA CLICK TO VIEW
OV9423 Ovarian Cancer N/A N/A CLICK TO VIEW
OV9427 Ovarian Cancer ADC N/A CLICK TO VIEW
OV9428 Ovarian Cancer NA NA CLICK TO VIEW

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