CrownBio Resources

Event WEBINAR: Next Generation Syngeneic Models to Facilitate Immuno-Oncology Research

September 24, 2020
9am/1pm ET
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Read More Publication Barcode Deep NGS-Based Profiling of Oncology Samples An estimated 15-25% of cell lines used for scientific experiments are either misidentified or..

Event WEBINAR: Animal Model Selection, Study Design, and Current Trends in..

September 30, 2020
11:00am EDT
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Read More White Paper How to Choose the Right Rodent Model for Preclinical Obesity Studies Best Practices in Obesity Model Selection and Study Design

Read More Quick Fact Organoids for Oncology Drug Discovery Utilize our unique in vitro clinical trial platform

Read More White Paper When and How to Use Tumor Organoids in Drug Discovery Compare the key benefits and applications of tumor organoids alongside conventional 2D and 3D..

Event Virtual Lunch and Learn: Translational Preclinical Platforms for CAR-T Cell..

October 14, 2020
12-1:00pm BST
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Event Biomarkers Series US

October 15-16, 2020 | PDT (UTC-7)
www.oxfordglobal.co.uk

Event 32nd EORTC-NCI-AACR Symposium

October 24-25, 2020
www.event.eortc.org

Watch Now Presentation CrownBio Virtual AACR 2020 Event Presentation Accelerate Cancer Drug Discovery by Utilizing a Patient-Derived Organoid Library

Read More Poster AACR20 Poster 180: Characterization and Comparison of Patient-Derived.. Patient-derived xenografts (PDX) are highly predictive in vivo models, due to their close..

Read More Poster AACR20 Poster LB-007: Genetically Engineered Organoid Models for Drug.. Organoids are a powerful translational tool for preclinical research with several advantages..

Read More Poster AACR20 Poster 2768: New Bioluminescent Orthotopic KPC Murine Homograft Model.. Advanced preclinical models are needed for drug development in pancreatic ductal adenocarcinoma..

Read More Poster AACR20 Poster 2788: Orthotopic, Bioluminescent Syngeneic Models for I/O.. Clinically relevant preclinical models recapitulating the human tumor microenvironment (TME) are..

Read More Poster AACR20 Poster 2798: Profiling the Cancer Stem Cell Components of PDX and.. Organoids are innovative in vitro 3D models, derived from stem cells from patient tissue.

Read More Poster AACR20 Poster 3328: New Online Baseline Covariate Balancing Tool Developed Effective randomization is essential for controlled, preclinical studies.

Read More Poster AACR20 Poster 4575: Universal mRNA Vaccine Proof of Concept using Syngeneic and.. Therapeutic cancer vaccines present a potential attractive immunotherapeutic approach as a..

Read More Poster AACR20 Poster 5614: Combination Anti-TIGIT and PD-1 Assessment with Double.. Combination immunotherapy has the potential to improve patient response rate to anti-PD-1..

Read More Poster AACR20 Poster 5615: Assess Human Specific Anti-CD47 Antibodies with.. Blockade of CD47/SIRPα signaling with anti-CD47 antibodies offers a promising anticancer..

Read More Poster AACR20 Poster 5616: Evaluate Immunotherapy Mechanism of Action with Immune Cell.. Cancer immunotherapies often work through more than one mechanism of action, mediated by..

Read More Poster AACR20 Poster 5963: Characterizing Preclinical Murine I/O Model Tumor-Immune.. Cancer is a heterogeneous disease, which is highly related to the immune system.

Watch Now On-Demand Webinar NASH Day 2020 On Demand Webinar Advances in Development of NHP Models of Diet-Enhanced NAFLD/NASH

Read More Poster ADA Poster 1829-P: Enhancing NASH in the MS-NASH Mouse through the GAN Diet Aggravating Liver Lipid Accumulation and Fibrosis in Nonalcoholic Steatohepatitis Model of..

Read More Quick Fact Genomics Services Advanced genomic analysis of preclinical study samples

Watch Now On-Demand Webinar In Silico Applications for In Vitro Drug Discovery To fully understand vast in vitro datasets and maximize translatability, analysis by qualified..

Read More White Paper 3 Preclinical Strategies to Identify Predictive Cancer Biomarkers Explore the Benefits of Biomarker Discovery in Early-Stage Drug Development

Watch Now On-Demand Webinar Tumor Organoids: A Paradigm Shift in Oncology Drug Discovery More clinically relevant models are urgently needed for preclinical oncology drug development.

Watch Now On-Demand Webinar Identifying Preclinical Immunotherapy Candidates Using a NHP Exploratory.. Learn how to leverage NHP exploratory toxicology studies to guide and explore lead optimization,..

Read More Publication Characterizing ZDSD Rat Metabolic and Hepatic Gene Expression Changes The ZDSD rat is a next generation animal model for studying type 2 diabetes and metabolic..

Read More Quick Fact Rodent Models of Liver Fibrosis Conventional models with rapid nutritional or chemical-induced fibrosis

Watch Now On-Demand Webinar 3D In Vitro Drug Discovery: When and How to Use Tumor Organoids The translatability of oncology cell lines and models used for preclinical in vitro drug..

Read More White Paper How to Detect, Characterize, and Evaluate CAR-T Cell Therapies Preclinical assessment of CAR-T cell therapies is challenging due to the lack of a single model..

Watch Now On-Demand Webinar 3 Strategies to Identify Clinically Predictive Biomarkers in the Preclinical.. Robust and sensitive biomarker discovery and validation is key to identifying the right patient..

Read More Quick Fact Rare Cell Analysis Sensitively detect, isolate, and characterize rare cells

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Read More White Paper Disrupting the Oncology Drug Development Workflow with PDXO Models Models with improved clinical relevance are needed for early stage preclinical drug development,..

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Read More Publication Key In Vivo Model Uses Across Cancer Drug Target Research In vivo tumor models are widely used to evaluate anticancer agents in the preclinical setting,..

Read More White Paper Advanced Statistical Analyses to Optimize MCTs Mouse clinical trials (MCT) using PDX models are a predictive and powerful platform to determine..

Watch Now On-Demand Webinar Applications of HUB Tumor Organoids in Oncology Drug Discovery Tumor organoids offer an innovative and predictive in vitro platform to revolutionize oncology..

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Read More Quick Fact Bioinformatics Integrated in silico modeling to accelerate drug discovery

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Read More Poster Minimizing Stress in Glucose Response Measurement with the BTT Spontaneously diabetic NHPs are a highly translatable preclinical model for the evaluation of..

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Read More Poster AACR-NCI-EORTC Poster A009: Imaging Systemic Hematologic Xenografts Establishment and Application of a Series of Systemic Bioluminescent Hematologic Cell Line..

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Read More Poster AACR-NCI-EORTC Poster A010: Enhancing Syngeneic Immunogenicity through OVA.. Development of OVA-Expressing Immunogenic Syngeneic Mouse Tumor Models: CT26-OVA and B16-OVA

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Read More Poster AACR-NCI-EORTC Poster A025: Correlating PDX Genomic and Proteomic Profiles Comparative Analysis of Proteomic and Transcriptomic Profiles of a Panel of Gastric Carcinoma..

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Read More Poster AACR-NCI-EORTC Poster A026: Developing an Automated Biomarker Discovery Platform An Automated Biomarker Discovery Platform based on In Vitro Pharmacology Raw Data

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Read More Poster AACR-NCI-EORTC Poster B041: Imaging Orthotopic Syngeneic Models Establishment of Orthotopic Syngeneic Models using Bioluminescent Imaging to Recapitulate the..

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Read More Poster AACR-NCI-EORTC Poster B068: New PDX-Derived Organoid (PDXO) Platform Establishing a Large Tumor Organoid Biobank using a Well-Characterized/Annotated Patient-Derived..

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Read More Poster AACR-NCI-EORTC Poster B142: New Immuno-Oncology Organoid Assay Co-Culture of Tumor Organoids with Immune Cells for Immuno-Oncology Drug Development

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Read More Poster AACR-NCI-EORTC Poster C102: Understanding Anti-PD-1 MOA Through Immune Cell.. Investigating Mechanisms of Action (MOA) of Anti-PD-1 Treatment by Systematic Depletion of..

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Read More Poster AACR-NCI-EORTC Poster C118: Implantation Site Effects on PDX Transcriptome Comparison of Orthotopic and Subcutaneous Patient-Derived Xenografts

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Read More Quick Fact Biomarker Discovery Increase your success rate by bridging discovery knowledge to clinical results

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Read More Quick Fact Proxy Study Director System Simplify global contract research with a local point of contact

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Watch Now On-Demand Webinar How to Detect, Characterize, and Evaluate CAR-T Cell Therapies CAR-T cell therapy is a rapidly advancing I/O treatment approach, genetically modifying a..

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Read More Publication CRMP Safety and Efficacy Confirmed in Clinically-Relevant NHP Models The Shulman Lab at Yale University has developed a controlled-release mitochondrial protonophore..

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Read More Quick Fact Cytokine and Chemokine Profiling Rapidly quantify bioactive proteins via high throughout profiling

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Read More Quick Fact Histology and Digital Pathology Accurately visualize drug effect through next generation IHC and IF

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Read More Publication Assessing CAR-T Cell Therapy for Gastric Cancer with PDX Models Despite advances in gastric cancer treatment and surgical techniques, overall survival rates for..

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Read More Publication Pancreatic Beta Cell Dysfunction and Diabetes Progression in NHP Models NHPs with spontaneously occurring type 2 diabetes provide the preclinical model most closely..

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Watch Now On-Demand Webinar Preclinical Obesity Research: Best Practice in Model Selection and Study Design Preclinical obesity research and drug development is complex and challenging.

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Read More Poster DoT Poster: New CDAHFD-Induced, Dysmetabolic NASH ZDSD Rat Model The ZDSD Rat, a Dysmetabolic Model with Intact Leptin Pathway, Develops NAFLD and NASH when Fed..

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Read More Quick Fact Biomarker Services Proteomic and genomic assays to uncover biomarkers of response

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Read More White Paper Advantages in 3D In Vitro Modeling with HUB Organoids Organoids, or “mini organs” in a dish, have recently been developed after many decades of..

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Watch Now On-Demand Webinar Demonstrating Clinical Relevance in 3D In Vitro Modeling with HUB Organoids Organoid technology has enormous potential for oncology research and anticancer agent drug..

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Watch Now On-Demand Webinar Reversing Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic NHPs with.. NAFLD is a major predisposing factor in the pathogenesis of hepatic insulin resistance, NASH,..

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Read More White Paper Identifying Immune-Related Toxicity with Non-GLP Exploratory NHP Toxicology.. The safety of immunotherapies is a major clinical concern which needs to be addressed early in..

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Read More Quick Fact Type 1 Diabetes Models Progress your antidiabetic agents with spontaneous and accelerated T1D models

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Read More Quick Fact Peritonitis Models Increase your study confidence using validated in vivo models

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Read More White Paper Novel Stress-Free Technologies to Optimize NHP Study Data NHPs are the most clinically relevant preclinical model for T2D research.

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Read More Publication How to Design, Apply, and Use Mouse Clinical Trials Mouse clinical trials (MCTs) employ panels of preclinical models in population-based efficacy..

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Read More Publication Diabetogenic Effects of Steptozocin in NHPs Streptozocin (STZ) is commonly used for diabetic induction in animal models due to its high..

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Read More Publication New NAFLD/NASH Mouse Model with Concurrent Metabolic Dysregulation Metabolic disorders, including insulin resistance, obesity, and hyperglycemia, are prominent..

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Watch Now On-Demand Webinar Assessing Immunotherapy Toxicity in NHPs Understand the NHP model features that provide an ideal preclinical model for elucidating..

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Read More White Paper Imaging Orthotopic and Metastatic Preclinical Tumor Models Orthotopic models provide a more predictive alternative, allowing establishment of a relevant..

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Watch Now On-Demand Webinar Overcoming Challenges in NAFLD/NASH Preclinical Modeling While the race for the first clinical NASH approval intensifies, preclinical research continues..

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Read More Poster Poster 303-LB: New Accelerated and Exacerbated NASH Fibrosis Preclinical Model Accelerated Hepatic Fibrosis in Western Diet-Fed Non-Alcoholic Steatohepatitis Mice Model by..

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Read More Poster Poster 1998-P: NAFLD/NASH Induction in a Dysmetabolic Model using High.. Progressive Liver Dysfunction Resulted from a High-Fat, High-Fructose Diet in MS-NASH (FATZO)..

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Read More White Paper Choosing and Implementing the Most Appropriate IBD Model There is a vast array of preclinical inflammatory bowel disease (IBD) models, each with their..

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Read More White Paper Advanced Models and Novel I/O Technologies for Preclinical PDAC Research Pancreatic cancer is a challenging disease due to resistance to a range of anticancer agents and..

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Watch Now Presentation The Jackson Laboratory’s Metabolic Disease Roadshow Presentation – Dr. Jim Wang The MS-NASH mouse (previously called FATZO) provides a more translatable preclinical model for..

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Read More White Paper Optimizing Syngeneic Translatability through POC and Target Engagement Studies While syngeneic tumor model use is widespread in preclinical immunotherapy drug development,..

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Read More Quick Fact NHP Exploratory Toxicology De-risk the path to GLP with early toxicity screening of I/O agents

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Read More Quick Fact SLE Models Advance SLE agent development with robust in vivo models

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Read More Quick Fact MS Models In vivo models to progress your MS inflammation agents to the clinic

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Watch Now Presentation NASH Summit 2019 Presentation - Dr Guodong Zhang Choosing a NASH preclinical model usually means selecting between different elements of the..

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Watch Now On-Demand Webinar How to Optimize Preclinical Diabetes Studies using Stress Free Methods in.. The key to fighting type 2 diabetes is to develop and utilize novel agents that control multiple..

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Read More Quick Fact NAFLDNASH in the MS-NASH Mouse Advance your NAFLD/NASH therapeutics with a rodent model that more closely mimics human..

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Read More Poster Comparing Manual and Computerized Preclinical NASH Scoring A Comparison of Computerized Pathology Readings with Manual Readout in the Same Set of NASH..

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Read More Quick Fact NAFLD/NASH in Dysmetabolic Non-Human Primates Increase your chances of clinical success with spontaneously obese, dysmetabolic, and diabetic..

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Read More Poster AACR Poster 5111: New Web Platform for Preclinical Data Analysis HuPharm: An interactive data analysis platform for preclinical studies

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Read More Poster AACR Poster 4976: Human CD40 Agonist Antibody Assessment with Human CD40 KI.. Ex Vivo Functional Characterization and In Vivo Efficacy Validation of Human CD40 Agonistic..

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Read More Poster AACR Poster 4621: Tumor Homografts for Prostate Cancer Combination Therapy.. Developing Genetically Modified Homograft Models of Mouse Prostate Cancer for Efficacy..

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Read More Poster AACR Poster 4613: Evaluating Mathematical Models of Tumor Growth Kinetics Mathematical Modeling of Tumor Growth in Mouse Models

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Read More Poster AACR Poster 4610: Predictive Biomarker Discovery in CRC using PDX Models Prognostic Impact of KRAS Driver Mutations and GSTT1 Expression in Colorectal Cancer to FOLFOX..

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Read More Poster AACR Poster 4609: Varied Panel of Sarcoma PDX Models Developed Establishment of Sarcoma PDX Models with Various Subtypes for Drug Efficacy Evaluation

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Read More Poster AACR Poster 4124: Optimizing a Functional ICB Screening Assay System Expression of Co-Inhibitory Molecules May Impact Immune Checkpoint Therapies

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Read More Poster AACR Poster 3418: Authenticating Tumor Models with an NGS-Based SNP Array A NGS-Based SNP Array for the Identification of Human Xenograft Tumors, Mouse Homograft Tumors,..

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Read More Poster AACR Poster 2375: Combination I/O Assessment with Double KI Checkpoint Target.. Developing Double Knock-In Models of Human Immune Checkpoint Targets (dKI HuGEMM™) for Efficacy..

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Read More Poster AACR Poster 2342: Developing GvHD Models with Human PBMCs and CD34+ Cells Experimental Modeling of Acute- and Chronic-GvHD by Xenotransplanting Human Donor PBMCs or Cord..

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Read More Poster AACR Poster 1925: New PDX-Derived Cancer Organoids Developed Establishment and Characterization of 3D Cancer Organoids as Clinically Relevant Ex Vivo Drug..

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Read More Poster AACR Poster 1503: Immune Cell Depletion Affects aPD-1 Efficacy Effect of Immune Cell Depletion on Response to PD-1 Treatment in Syngeneic Models

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Read More Poster AACR Poster 1443: New Method for Detecting and Monitoring CAR-T Cells in.. Sensitive Detection and Quantification of CAR-T Cells in Treated Patients

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Read More Poster AACR Poster 1060: Prostate Cancer PDX for Predictive Preclinical Studies Establishment of a Panel of Prostate Patient-Derived Xenograft (PDX) Models and Evaluation of..

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Read More Poster AACR Poster 87: Bioluminescent Imaging of Orthotopic Syngeneic Models Recapitulating the Orthotopic Tumor Microenvironment using Bioluminescent Syngeneic Models in..

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Read More Quick Fact Syngeneic Models Well-characterized syngeneic tumor models for immunotherapy assessment

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Read More Quick Fact MuScreen Syngeneic and tumor homograft in vivo immunotherapy screening

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Read More Quick Fact MuPrime Tumor Homografts Immunocompetent models carrying clinically-relevant oncogenic mutations

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Read More Quick Fact HuGEMM and HuCELL Humanized drug target models for immunotherapy evaluation

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Read More Quick Fact Genetically Modified Models Reliable, stable, proven technology for custom animal model generation

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Watch Now On-Demand Webinar How to Leverage Tumor Models for Pancreatic Cancer Research Pancreatic cancer is a challenging disease to research, in both the preclinical and clinical..

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Read More Quick Fact Non-GLP Toxicology and Safety Pharmacology Studies Gain maximum confidence for regulatory submissions through our range of Non-GLP Toxicology and..

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Watch Now On-Demand Webinar Imaging Orthotopic and Metastatic Preclinical Models for Oncology Drug Discovery Orthotopic tumor models have many advantages over subcutaneous counterparts, including..

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Read More Poster Prostate Cancer Tumor Homografts for I/O Assessment New preclinical models are needed for prostate cancer drug development, which can be used to..

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Watch Now On-Demand Webinar Exploring Translational Capabilities of Preclinical IBD Models The development of a variety of preclinical models has advanced our understanding of underlying..

Read More Poster Stress Echocardiography Test to Assess Cardiac Dysfunction in NHPs Developed Intervention studies in human-like species such as NHPs can strengthen target validation and..

Read More Poster IDDST 2018 Presentation Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are becoming..

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Read More Poster Diabetes Summit 2018 Presentation With diabetes prevalence continuing to rise, improved methods are needed for glucose monitoring..

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Read More Quick Fact Clinical Chemistry and Biomarker Services Make confident decisions from rapid, reliable data in your early preclinical cardiovascular and..

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Watch Now On-Demand Webinar Translational Platforms of Obesity, Dysmetabolism, Diabetes, and Complications A key challenge in preclinical obesity, dysmetabolism, and diabetes studies is the lack of..

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Watch Now On-Demand Webinar Preclinical Prostate Cancer Models: Which One is Right For You? Preclinical prostate cancer research is hampered by a lack of predictive models to investigate..

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Read More Poster Poster: Using PDX for In Vivo CAR-T Cell Therapy Assessment Efficient growth suppression of pancreatic cancer PDX by fully human anti-mesothelin CAR-T cells

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Read More Poster Poster 329: Orthotopic Syngeneics: More Clinically Relevant I/O Models Recapitulating the orthotopic tumour microenvironment using bioluminescent syngeneic models in..

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Read More Poster Poster 327: Prostate Cancer Patient-Derived Xenograft Treatment Data Evaluation of anti-androgen therapy in a panel of prostate patient-derived xenograft models

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Read More Poster Poster 313: Orthotopic Homograft Tumours Display Distinct TIL Patterns Orthotopic homograft tumours (syngeneic) display distinct tumour infiltrate immune cell patterns..

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Read More Poster Poster 312: Comparing Kidney Cancer Genomics Across Populations Genomic characterisation of Chinese clear cell renal cell carcinoma revealed novel prognostic..

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Read More Poster Poster 305: Comparing Categorical Response Methods for Tumour Model Studies Evaluation of categorical response methods in predicting drug responses in transplanted tumour..

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Read More Poster Poster 250: Tumour Homografts for Prostate Cancer I/O Development Establishment of mouse prostate homograft tumour models for efficacy evaluation of combinatory..

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Read More Poster Poster 241: Characterising Syngeneics to Guide Model Selection Utilising murine syngeneic model systems in I/O drug discovery: broad applications and guidance..

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Read More Poster Poster 240: Evaluate Bispecific Antibodies with PBMC-Humanised Models Establishment and application of a panel of PBMC-humanised mouse tumour models in..

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Read More Poster Poster 226: Immune Checkpoint Double Knock-In Models for I/O Testing Generation of human immune checkpoint double knock-in mice (dKI HuGEMM™) for preclinical..

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Read More Publication Assessing CAR-T Cell Therapy for Pancreatic Cancer with PDX Models Despite an improvement in our knowledge of pancreatic cancer biology, standard of care treatment..

Read More Publication Profiling the TME of PDAC Tumor Homografts Pancreatic ductal adenocarcinoma (PDAC) does not respond to a range of cancer therapies (e.g...

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Read More Publication Using MCT to Identify EGFR Predictive Biomarker in ESCC Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal tumors...

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Watch Now On-Demand Webinar Patient-Derived Xenografts as Models for Metastatic Breast Cancer and.. Breast cancer is a highly heterogeneous, complex disease affecting millions of women worldwide...

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Read More Poster Poster 1021: New Preclinical Mouse Model of Diabetic Nephropathy Next Generation of Spontaneous Diabetic Model of MS-NASH (FATZO) Mice with Intact Leptin..

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Read More Poster Poster 535: New Preclinical Model for Diabetic Cardiomyopathy Next Generation of Spontaneous Diabetic Model of ZDSD Rats with Intact Leptin Signaling Develop..

Read More Poster Poster 3.9: Novel Uses for PDX Models in Preclinical Drug Development Cancers are diverse genetic and immunological abnormalities, which results in specific..

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Read More White Paper New Advancements in Preclinical Prostate Cancer PDX Models Enhance Prostate Cancer Drug Development with More Translational Preclinical Models including..

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Watch Now Presentation Tumour Models London 17 Presentation - Dr Rajendra Kumari There is an increasing demand for clinically relevant and predictive models in preclinical..

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Read More Quick Fact ADME, DMPK, and Bioanalysis Integrated in vitro and in vivo pharmacological and bioanalytical platform

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Read More White Paper Immunocompetent Murine Models: A Guide to Understanding their Place in.. The Challenge: How to Explore and Evaluate Novel Immunotherapies and Combination Regimens before..

Read More Poster Assess Targeted I/O Agents with PBMC-Humanized Models There is an increasing need for fast, reliable, and cost-effective immunocompetent models for..

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Read More Poster Discover Robust 3D Ex Vivo Compound Screening Ex vivo cancer pharmacology has shown advantages over in vitro and in vivo approaches in..

Read More Poster Novel PDAC Murine Homografts for I/O Drug Development Preclinical, immunocompetent models are needed for immunotherapy drug development in pancreatic..

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Read More Poster Bispecific Antibody Evaluation via CD3E Transgenic Model Preclinical development and evaluation of T cell-redirecting antibodies is often blocked by a..

Read More Poster ZDSD Rat Preclinical Model for Cardiomyopathy Drug Discovery Cardiomyopathy is the leading cause of morbidity and mortality among diabetes and obesity..

Read More Poster Patient Relevant Immune Cell Response in MS-NASH (FATZO) T2D Model Type 2 diabetes and obesity are strongly associated with a peripheral immune response. Disease..

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Read More Poster Bioluminescent Orthotopic Syngeneics for I/O Assessment There are limited treatment options available for hepatocellular carcinoma (HCC), which is an..

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Read More Poster In Vitro Assay Platform to Test Anti-CD47 Agents CD47 is a transmembrane protein belonging to the immunoglobulin family. It acts as a “don’t eat..

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Read More Poster Improved CD3E Transgenic Mouse Model for I/O Agent Testing Preclinical models are required to test T cell-redirecting bispecific antibodies targeting CD3E...

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Read More Poster NAFLD/NASH Mouse Model with Metabolic Dysregulation Metabolic disturbances such as insulin resistance, obesity, and dyslipidemia are prominent risk..

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Read More Poster Investigating the TME through PDX RNAseq Analysis Cancers are collections of diverse diseases, of both genetic and immunological abnormalities...

Read More Poster WES and RNAseq Comparison of PDX Mutations Patient-derived xenografts (PDX) are widely used, highly predictive, preclinical oncology..

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Read More Poster Poster a90037: DGAT-1 Inhibition in Obese Mice vs NHPs The microsomal enzyme diacylglycerol O-acyltransferase 1 (DGAT-1) plays a key role in the..

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Read More Poster Poster a90026: Banana Tolerance Test – A Stress Free Alternative to oGTT Spontaneously diabetic NHPs are a highly translatable preclinical model for the evaluation of..

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Read More Poster KPC Homograft Models for PDAC Combination I/O Studies Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult to treat cancer types,..

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Read More Poster Microbiota Enrichment Associated with PD-1 Response Studies have shown that the gut microbiome may influence antitumor immune response via innate..

Read More Poster DLBCL PDX Models with Diverse Genotypes for BTKi Testing Bruton's tyrosine kinase (BTK) activation is a major oncogenic driver for various B cell-derived..

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Read More Poster IDO1 Inhibition Assay Measuring Kyn Levels Developed IDO1 is a major mechanism of immunosuppression in tumors, with expression of IDO1 by tumor cells..

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Read More Poster New Ex Vivo PDX Compound Screening Platform Patient-derived xenograft (PDX) models are in high demand in preclinical drug development due to..

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Read More Poster TIL-Treg Subtype Shift Induced by Vaccination Tumor infiltrating lymphocytes, including regulatory T cells (Treg), are believed to play a..

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Read More Poster Disrupting the CD47-SIRPa Anti-Phagocytic Axis in I/O Macrophages provide an important surveillance system, which can be escaped by human tumors..

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Read More Poster Recapitulating the TME in Ex Vivo 3D Tumor Growth Assay The assessment of novel tumor microenvironment (TME) targeting therapies is currently hindered..

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Read More Poster Using Genetic Features to ID and QC Murine I/O Models Mouse tumor homografts (derived from syngeneics, GEMM, etc.) engrafted in their corresponding..

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Read More Poster CD3E Transgenic Mouse Model for Bispecific Antibody Testing T cell-redirecting therapy is taking a prominent role in immuno-oncology. Recent research has..

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Read More Poster PBMC-Humanized Models for Targeted Cancer Immunotherapy Monoclonal antibodies and checkpoint inhibitors have achieved remarkable clinical success in..

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Read More Poster KPC Homograft Models for PDAC Combination Immunotherapy Development Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and remains one of the..

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Read More Poster Humanized OX40 Mouse Models for Preclinical I/O Studies OX40 is a co-stimulatory receptor of the TNF receptor superfamily, and is at the forefront of..

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Read More Poster Using PDX as Surrogate Models for TME Investigation Cancers are being increasingly recognized as collections of diverse immune diseases, on top of..

Read More Poster PBMC-Humanized Models for In Vivo I/O Studies The recent rise in cancer immunotherapy research and drug approvals is providing promising..

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Read More Poster Orthotopic, Bioluminescent Syngeneic HCC Models for Immunotherapy Assessment There are currently limited treatment options for hepatocellular carcinoma (HCC), which is a..

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Read More Poster Orthotopic, Bioluminescent Ovarian Cancer Xenograft Models Developed Due to late diagnoses and common treatment failure, ovarian cancer has a high lethality, and is..

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Read More Poster Evaluate Human Origin OX40 Therapeutics In Vivo OX40, a member of the TNF superfamily, is now at the forefront of the field known as “T cell..

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Read More Poster Evaluate Human-Specific Immunotherapies In Vivo Immunotherapies have demonstrated considerable success in oncology research, treating a variety..

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Read More Poster Treatment of Patient-Derived NSCLC Xenograft Preclinical Models Using.. Radiotherapy is a primary, adjuvant or neoadjuvant treatment for a number of different cancers..

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Read More Publication Positive Impact of Omega-3 on CVD Risk Factors in Dyslipidemic NHPs High serum cholesterol levels, particularly LDL cholesterol, are a significant cardiovascular..

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Read More Publication Effects of Increasing Omega-3 Index on Erythrocyte Membrane Fatty Acid Levels The omega-3 index is a commonly used method to reflect the intake of the long-chain omega-3..

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Read More Publication ZDSD Rat Characterization Metabolic diseases are broadly defined as pathological conditions caused by dysregulation of..

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Read More Publication Insulin Resistance Similarities in Diabetic NHPs and Humans Insulin resistance and diabetes can develop spontaneously with obesity and aging in rhesus..

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Read More Publication NHP Liver Expresses Abundant Betatrophin mRNA Betatrophin reportedly plays a major role on stimulating proliferation of islet cells and..

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Read More Publication Naturally Obese NHPs – Highly Translatable Animal Models for Human Dysmetabolism Many animal models have been used to research and understand the mechanisms of obesity, and to..

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Read More Publication First Detailed Characterization of Diabetic Nephropathy in NHPs It is well-recognized that non-human primate (NHP) models of diabetes and metabolic disease..

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Read More Publication Naturally Diabetic NHPs – The Most Predictive Animal Model for Human Disease Various animal models have been used in research for understanding diabetes and metabolic..

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Read More Publication GGI and C-Peptide Deconvolution - Powerful Translational Tools for Diabetes.. Quantitation of β-cell function is critical to better understand the dynamic interactions of..

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Read More Publication Xylazine Causes Acute Hyperglycemia in NHPs The α2-adrenoceptor agonist xylazine has been widely used as an anesthetic in veterinary clinics..

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Read More Publication ccRCC Intra-Tumor Molecular Heterogeneity Influences Targeted Therapy Response Both inter- and intra-tumor molecular heterogeneity are increasingly being recognized in clear..

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Read More Publication Confirmed - High Relevance of PDX as Surrogate Experimental Models The accurate diagnosis of cancer types is needed to understand disease development and..

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Read More Publication NSCLC PDX Models with EGFR Exon 20 Insertions Developed Activating EGFR mutations are oncogenic drivers in a significant proportion of NSCLC cases...

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Read More Publication New DAAP ALK Inhibitor Series Discovered Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that belongs to the insulin..

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Read More FactSheet ZDSD Rat Factsheet The ZDSD polygenic rat model with functional leptin pathway, a highly translatable model which..

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Read More FactSheet Rodent Models of Diabetes Rodent models of diabetes and our study services including continuous glucose determination.

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Read More FactSheet MS-NASH Mouse Model The MS-NASH (FATZO) polygenic mouse model with functional leptin pathway, a more translatable..

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Read More FactSheet Spontaneously Diabetic NHPs Spontaneously diabetic NHPs which mirror human disease phenotype, metabolic defects, and..

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Read More FactSheet NAFLD/NASH in the MS-NASH Mouse The MS-NASH model, which develops NAFLD/NASH in an inherently dysmetabolic, obese, and diabetic..

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Read More FactSheet Rodent Models of Obesity Rodent models of obesity technologies and resources including our main study endpoints.

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Read More FactSheet Non-Human Primate Models of Obesity Spontaneous and diet-induced NHP models of obesity allowing research on metabolic dysfunction..

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Read More FactSheet Rodent Models of Renal Disease Rodent models of renal disease including genetically relevant, translatable, and induced disease..

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Read More FactSheet Non-GLP Toxicology and Safety Pharmacology Studies CrownBio also provides details on our comprehensive Non-GLP Toxicology and Safety Pharmacology..

Read More FactSheet CAR-T Therapy Preclinical evaluation of CAR-T therapies in vivo using our novel Patient-Derived Xenograft..

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Read More FactSheet MiXeno™ MiXeno™ models featuring transient human immunity in mice, providing a simple alternative to the..

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Read More FactSheet HuGEMM™ and HuCELL™ Models HuGEMM™ and HuCELL™, our unique platforms for evaluation of targeted human-specific..

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Read More FactSheet Syngeneic Models Syngeneic models, showcasing our ever expanding syngeneic collection, FACS analysis, and..

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Read More FactSheet MuScreen™ MuScreen™ CrownBio’s large-scale, screening platform to fast-track the in vivo screening of..

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Read More FactSheet MuPrime™ Model MuPrime™ - homografts of spontaneous murine tumors (from GEMM/carcinogen-induced models),..

Read More FactSheet RET Fusion RET fusion in CRC PDX models, including model response to RET inhibitor treatment, and the..

Read More FactSheet FGFR3 Fusion In Vivo Xenograft Platform Our FGFR3 fusion in vivo xenograft platform covering both patient and cell line derived..

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Read More FactSheet HuPrime® Our PDX collection key features are summarized in our HuPrime® FactSheet

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Read More FactSheet HuKemia® Discover our validated stable HuKemia® models, the only commercial blood cancer PDX models to..

Read More FactSheet GIST PDX Models Use the world's most comprehensive GIST PDX collection to evaluate the next generation of..

Read More FactSheet NHL DLBCL PDX Models Read how to accelerate NHL DLBCL targeted agent and combination therapy drug discovery programs..

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Watch Now On-Demand Webinar How to Maximize Your Non-GLP Toxicology Studies: A Guide for Optimal Design and.. Prior to clinical studies in humans, an investigational new drug (IND) application must be..

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Watch Now On-Demand Webinar NAFLD/NASH: Strategies for Accelerating Drug Discovery with an Improved.. Metabolic disturbances such as insulin resistance, obesity, and dyslipidemia are prominent risk..

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Watch Now On-Demand Webinar Translational Platforms to Model Pre-Diabetes, Diabetes, and Diabetic.. A key challenge in preclinical studies of diabetes is the lack of translational platforms that..

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Watch Now On-Demand Webinar Vascular and Neural Complications in Rodent Models of Obesity and Type 2.. Peripheral neuropathy affects around 50% of the diabetic population. Manifestations range from..

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Watch Now On-Demand Webinar Microbiome Drug Development with Whole Communities and Defined Consortia Microbiome therapies are still in their infancy, but are rapidly advancing into clinical testing..

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Read More FactSheet MuBase® Use our unique online database MuBase® to quickly and easily identify the most suitable murine..

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Watch Now On-Demand Webinar Are You Choosing the Right Model? A Guide to Selecting Your Next.. Recent regulatory approvals and fast-track designations have signified the coming of age of..

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Watch Now On-Demand Webinar Beyond Syngeneics – Novel Tools for Addressing Human Specificity in.. Checkpoint inhibitors such as anti-PD-1, anti-PD-L1, and anti-CTLA-4 have revolutionized..

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Watch Now On-Demand Webinar Clinically Relevant Cell-Based Solutions for Target Identification Target identification studies play a critical role in the early stages of cancer drug discovery..

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Read More FactSheet 3D Cell Culture Platform In Vitro/Ex Vivo Assays for Cancer Pharmacology Our 3D cell culture platforms described in detail, including the 3D tumor growth assay (3D TGA)..

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Watch Now On-Demand Webinar Exploring Translational Capabilities of PDX Models across In Vivo, In Vitro and.. The development of novel cancer therapies to take into the clinic requires significant..

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Watch Now On-Demand Webinar Immuno-Oncology: 3 Strategies for Applying Humanized Models The evaluation of human specific immunotherapeutics is hampered by a lack of preclinical..

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Watch Now On-Demand Webinar In Vitro and Ex Vivo Assays to Accelerate Immuno-Oncology Drug Discovery Immunotherapy represents one of the most promising cancer treatment approaches in modern..

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Watch Now On-Demand Webinar Interrogating Syngeneic Models in Large Scale, How to Use Immunoprofiling Data.. Syngeneic models are a standard preclinical platform for evaluating immunotherapies. However,..

Watch Now On-Demand Webinar Mouse Clinical Trials: The Power Behind Study Design It is widely known that the attrition rate of oncology drugs in the clinical setting can be..

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Watch Now On-Demand Webinar Murine Immuno-Oncology Models: A Head-to-Head Comparison Between Syngeneics and.. Syngeneics have been the mainstay model for surrogate immunotherapy evaluation as an..

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Watch Now On-Demand Webinar Patient-Derived Xenografts: New Advancements in Preclinical Prostate Cancer.. Prostate cancer is a highly heterogeneous disease, with extremely complex biological, hormonal,..

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Watch Now On-Demand Webinar The Ultimate Guide to Mouse Clinical Trials The cost of bringing a new drug to market carries a high price, however it is even more costly..

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Read More Application Note HuTrial™ Case Studies CrownBio presents a variety of interesting and diverse mouse clinical trials, using our PDX..

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Read More Application Note In Vitro and Ex Vivo Immuno-Oncology Drug Discovery Discover how CrownBio’s comprehensive Immuno-Oncology platform allows end-to-end in vitro and ex..

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Read More Quick Fact MS-NASH mouse Highly translatable model for diabetes, obesity, and metabolic syndrome

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Read More Quick Fact NHP models of obesity Spontaneous and diet-induced models for obesity research

Read More Quick Fact PKD models Human disease relevant mouse model of polycystic kidney disease

Read More Quick Fact Spontaneously diabetic NHPs The most translatable animal model in Type 2 diabetes research

Read More Quick Fact ZDSD rat Highly translatable model for obesity, metabolic syndrome, diabetes, and diabetic complications

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Read More Quick Fact IBD Models Preclinical platform to advance inflammation drug discovery

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Read More Quick Fact RA Models Translational preclinical platform to speed RA drug discovery

Read More Quick Fact 3D PDX Screen A rapid translational ex vivo screening platform

Read More Quick Fact CrownSyn™ Bioinformatics tool to simplify two-drug combination analysis

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Read More Quick Fact Flow Cytometry Robust immunophenotyping to inform immunotherapeutic development

Read More Quick Fact HuBase™ Online searchable Patient-Derived Xenograft (PDX) database

Read More Quick Fact HuKemia® Patient-derived blood cancer models

Read More Quick Fact HuMark™ Discovery and validation of novel oncology biomarkers

Read More Quick Fact HuPrime® The world’s largest commercial collection of well-characterized PDX models

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Read More Quick Fact HuSignature™ Discovery and validation of genetic signatures of response

Read More Quick Fact HuTrial™ Mouse clinical trials using PDX models

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Read More Quick Fact Immuno-Oncology Platforms Discover an integrated in vitro, ex vivo, and in vivo I/O model portfolio

Read More Quick Fact MuBase® Find the most suitable murine oncology models for your preclinical studies

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Read More Quick Fact OmniPanel™ CrownBio collection of over 400 cell lines for in vitro studies

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Read More Quick Fact OmniScreen™ Well-validated, large-scale cell panel screening platform

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Read More Quick Fact OncoExpress™ One stop search engine for Oncology models including PDX, cell line derived xenografts, and..

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Read More Quick Fact PrimePanel™ PrimePanel are isolated primary cells from patient-derived tumor tissues for in vitro drug..

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Read More Quick Fact Radiation Therapy Precision radiotherapy with applications from subcutaneous to metastatic studies

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Read More Quick Fact Cell-Based Target Identification Discover an integrated oncology portfolio providing cell-based solutions for target..

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Read More Quick Fact XenoBase® - Which cell line is best for your cancer study? One click in XenoBase gives you instant access to a unique database of over 1000 tumor cell..

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Read More Quick Fact XenoSelect™ - Faster in vitro to in vivo study translation A diverse, oncogenic in vitro screening panel of more than 150 cell lines ready for in vivo..

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Read More Application Note Spontaneously Diabetic NHPs Discover our collection of naturally diabetic NHPs (the most clinically translatable animal..

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Read More White Paper NAFLD/NASH: Accelerating Drug Discovery with an Improved Metabolic.. Nonalcoholic steatohepatitis (NASH) is an increasing public health issue, with no currently..

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Read More White Paper Translational Platforms to Model Pre-Diabetes, Diabetes, and Diabetic.. Modeling human diabetes in animal models is challenging – currently available models only mimic..

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Read More White Paper Exploring Translational Capabilities of PDX Models across In Vivo, In Vitro,.. Patient-derived xenografts are recognized as the most predictive preclinical model available for..

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Read More White Paper How to Choose the Correct I/O Model As immuno-oncology continues to grow as a therapeutic area, more preclinical research is driven..

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Read More White Paper Optimize Target Identification and MOA Studies Correctly identifying drug targets and elucidating MOA is a critical stage in early drug..

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Read More White Paper 3 Strategies for Applying Humanized Models Immunotherapeutics have proven to be a game changer in oncology – bringing tremendous patient..

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Read More White Paper Precision Profiling With PDX Oncology drug development is inefficient and expensive, costs quickly spiral upwards while..

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Read More White Paper The Ultimate Guide to Mouse Clinical Trials Traditional oncology drug development strategies are failing – oncology agents have a higher..

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Read More White Paper The Importance of Using an Isotype Control The accurate measurement of drug effects requires the use of an appropriate negative control...

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Read More Publication ZDSD Rat – A Dysmetabolic Model to Study Cardiomyopathy Treatment Approaches Diabetic cardiomyopathy (DC) is the leading cause of morbidity and mortality among all..

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Read More Application Note NHP Models of Obesity Obesity is becoming a serious epidemic issue across the world, and has already become one of the..