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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Resources

Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Blogs

Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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Genomics and Transcriptomics Services

Comprehensive solutions delivering high-quality genomics results and advanced data analysis

Genomics and transcriptomics services have revolutionized drug discovery and development by enabling researchers to better understand disease mechanisms and identify potential drug targets. To provide the highest quality genomics and transcriptomics services, we have invested in industry-leading equipment and developed automated workflows to ensure reproducible results.

Integrate our genomics services with your in vivo or in vitro studies with us, or use it as standalone service

  • Explore and validate drug mechanism of action with advanced genomic analysis
  • Identify genetics features associated with drug response through genomics profiling
  • Understand drug resistance by interrogating the immunogenomics of tumor-immune interactions
  • Take advantage of our proprietary tools and model data including our database of NGS-characterized model

Comprehensive Translational Genomics and Transcriptomics Services

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Key Advantages of Our Genomics and Transcriptomics Services

  • Expertise: Our team of experienced scientists, laboratory technicians, and bioinformaticians have extensive knowledge and expertise in the latest technologies and methodologies.
  • Customization: We work closely with our clients to understand their research needs and design customized solutions that deliver reliable and reproducible results.
  • Quality: We adhere to strict quality control measures throughout workflow to ensure accurate and consistent data generation.
  • Speed: Fast turnaround times without compromising quality.
  • Comprehensive capabilities: Our wide range of industry-leading equipment enables us to offer comprehensive capabilities for a variety of research needs.
  • Data analysis support: Our bioinformatics team provides expert data analysis and interpretation, ensuring that our clients have access to meaningful insights from their data.

Our key technology platforms include:

  • Next-Generation Sequencing (NGS): MGISEQ-2000 and Illumina NovaSeq 6000 sequencing platforms, for cost-efficient and high-quality sequencing data for a wide range of applications.
  • Long-read sequencing: PacBio third-generation sequencing, for de novo genome assembly, structural variation detection, and microbiome sequencing.
  • Optical genome mapping: Bionano Saphyr system, for high-resolution structural variation detection and genome assembly.
  • Single-cell sequencing: 10x Genomics platform, for high-throughput single-cell sequencing for transcriptomics and epigenetics analysis.
  • NanoString: nCounter and GeoMx platforms, for high-throughput gene expression analysis and spatial biology.

 

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Standard Genomics Services

  • Sample preparation: DNA/RNA extraction, mRNA purification, microRNA extraction, and NGS library preparation
  • Conventional assays: Target gene expression assay, virus copy number assay, gene copy number variation analysis, gene mutation validation, and gene fusion validation

Advanced Genomics and Next-Generation Sequencing Services

  • RNA-Seq, WES, WGS, WGBS, lncRNA-seq, single-cell sequencing, PacBio long read sequencing, Bionano structural variation detection, microbiome sequencing (full-length 16S sequencing, metagenomics sequencing, and metatranscriptomics sequencing), and Nanostring services

Mouse I/O RNA-Seq Panel

  • Get rapid transcriptomic insights into key immune cell populations, I/O pathways and processes in the tumor microenvironment by comprehensive profiling of 1080 genes from a single sample

Cell Line Authentication with Deep Sequencing

  • The first commercial deep sequencing-based CLA service. Significantly overperforms with increased accuracy, sensitivity, throughout, and provides more extensive information compared to conventional PCR-based STR assay.

NGS data analysis

  • Maximize the value of your NGS data with our bioinformatics analysis services.

 

Elevate your drug discovery

Contact us for leading genomics & transcriptomics services with automation.