Why Humanized Mouse Models?
They allow direct in vivo evaluation of human-specific immunotherapies, which traditional murine systems can’t achieve. By engineering mice to express human drug targets like checkpoint proteins within a fully functional immune system, these models deliver a translationally relevant and efficient alternative to fully humanized systems. They are particularly powerful for studying antibody combinations, immune memory, and checkpoint inhibitors.
Humanized mouse models enable teams to:
- Study a broad range of human immunotherapy targets in vivo using humanized receptors and ligands.
- Evaluate agents when murine orthologs are non-functional or absent, ensuring target engagement.
- Reduce cost and complexity compared to human immune system (HIS) models while preserving mechanistic insight.
Generation of Humanized Target Tumor Bearing Models for Immunotherapy Evaluation
Model Highlights
Evaluate single or dual targeted immunotherapies using validated humanized immune models and tumor lines engineered to express human ligands.
Single and double knock-in models expressing human PD-1, PD-L1, CTLA-4, and others. Support in vivo testing of FDA-approved and novel immune checkpoint inhibitors.
Syngeneic tumor cell lines are engineered with human ligand expression (e.g., MC38-hPD-L1) for modeling dual interactions between tumor and immune components.
