WEBINAR: Interrogating Syngeneic Models in Large Scale, How to Use Immunoprofiling Data to Improve your Studies

1st March 11am EST

Presented by Dr Henry Li, this webinar explores the detailed data analysis behind the industry's first large-scale, staggered, syngeneic screening platform for immunotherapy development. Learn how this platform can improve efficiency and reproducibility while reducing cost, how comprehensive immunophenotyping and profiling data is used to address key study design questions, and how RNAseq and FACS/IHC analysis are used for biomarker discovery.

WHITE PAPER: Immuno-Oncology - 3 Strategies for Applying Humanized Models

Enhance your humanized mouse immuno-oncology studies through a deeper understanding of model immunological features and optimized uses. Learn more about immune system humanization strategies, and how these result in different models with contrasting features and limitations, then explore model applications through cancer pharmacology case studies.

SYMPOSIUM: Perspectives on Oncology Drug Discovery; Immuno-Oncology and the Next Generation

15th March 2018 - Babraham Research Campus, Cambridge, UK

CrownBio invites you to attend a symposium focusing on immuno-oncology and future advances in cancer treatment. Key discussion topics include novel targets for next generation immunotherapeutics and the evolution of preclinical models for improved I/O agent assessment.

Custom Cell Lines for Research Use and Biopharmaceutical Applications

Developing stable cell lines can be time-consuming and complex. Simplify your cell line development efforts for protein production and cell-based assays.

Get Your Free Poster

Learn more about the world's largest patient-derived xenograft (PDX) collection. Download or request a poster today.

Custom Antibodies

Having trouble finding a suitable antibody for your studies? Explore our broad platform of protein services, ranging from monoclonal antibody development, large-scale protein production & purification, and custom antibody conjugations.

ON-DEMAND WEBINAR: Immuno-Oncology: 3 Strategies for Applying Humanized Models

Presented by Dr Jayant Thatte this webinar explores humanized mouse models and their application in preclinical immunotherapeutic development. Learn about the different humanization strategies available, the pros and cons of each humanized model type, and successful model use through I/O case studies.

Missed us at Tumor Models San Francisco 2018?

Watch our presentation on humanized drug target models for in vivo immuno-oncology assessment, and download our posters now:

Characterization and Optimization of MiXeno™, PBMC-Humanized Mouse Tumor Models, for the Evaluation of the In Vivo Activity of Immunotherapeutics

Transcriptomic Analysis of Patient-Derived Xenografts Reveals Heterogeneity in Human and Mouse Stroma/Immune Compartments

Watch Henry Li present EORTC 17 Short Talk

Hear Dr Henry Li, Vice President of Biomarker and Diagnostic Technology present our AACR-NCI-EORTC 2017 selected Short Talk titled 'Transcriptomic analysis of patient-derived xenografts reveals heterogeneity in human and mouse stroma/immune compartments'

ON DEMAND WEBINAR: Clinically Relevant Cell-Based Solutions for Target Identification

Learn how to leverage CrownBio's integrated Oncology Portfolio to advance your Target Identification studies. Watch our webinar presented by Michelle Mack.

ON DEMAND WEBINAR: Mouse Clinical Trials: The Power Behind Study Design

Presented by Dr Sheng Guo this webinar covers the key aspects of how to design PDX Mouse Clinical Trials to fully address the key questions in drug discovery programs. Learn how: to select the optimal number of models and mice for your study, to quantify and evaluate your drug’s efficacy, and to use MCT data to leverage biomarker discovery.

ON DEMAND WEBINAR: Beyond Syngeneics – Novel Tools for Addressing Human Specificity in Immuno-Oncology

Presented by Michelle Mack this webinar presents novel humanized drug target models (e.g. for PD-1, CTLA-4, PD-L1) for investigating human specificity in immunocompetent mice, and evauating human-specific immuno-oncology agents in vivo.

NEW WHITE PAPER: The Ultimate Guide to Mouse Clinical Trials

Transform your preclinical oncology drug development, with mouse clinical trials using patient-derived xenograft (PDX) models. Learn how the different types of MCT are executed, which is the best fit for your specific drug discovery program, and how they provide the perfect framework for biomarker discovery.

Missed us at the AACR New Horizons in Cancer Research Conference?

Read and download all of our 12 posters now!

ON DEMAND WEBINAR: The Ultimate Guide to Mouse Clinical Trials

Presented by Dr. John MacDougall this webinar presents Mouse Clinical Trials (MCT) using PDX models, and will help to guide you through the process of determining which MCT best suits the specific needs of any given drug development program.

NEW WHITE PAPER: A Guide to Selecting Your Next Immuno-Oncology Model

Improve your model selection decision for any immuno-oncology study by exploring the immunocompetent model types within this white paper. Learn more about the features, limitations and major uses of each type and how to apply them to your next study.

High Fidelity CRISPR Cell Line Engineering Services

Make better go/no-go decisions with CRISPR Engineered Cell Line Services.

CrownBio provides efficient, cost-effective gene editing services using licensed CRISPR/Cas9 technology. Our experts can generate knock in and knockout cell lines with vector controls that are tailored to meet your specific needs and help you advance your preclinical drug development programs.

ON DEMAND WEBINAR: How to Maximize Your Non-GLP Toxicology Studies: A Guide for Optimal Design and Methodology

Presented by Dr. Keefe Chng and Dr Judith Gorski this webinar will help guide you through a study design process that will enable the greatest opportunity to generate robust, high-quality data, that gives maximum confidence to select new drug candidates and regulatory submissions.

ON DEMAND WEBINAR: Vascular and Neural Complications in Rodent Models of Obesity and Type 2 Diabetes

Watch this scientific webinar presented by Dr. Mark Yorek, Professor of Medicine at University of Iowa and Associate Chief of Staff for Research at Iowa City VA. He will discuss the challenges in modeling diabetic neuropathy and how the use of improved translational rodent models can impact Diabetes and Obesity pre-clinical studies.

ON-DEMAND WEBINAR: Are You Choosing the Right Model?

A Guide to Selecting Your Next Immuno-Oncology Model

Join our webinar to discover the wide range of in vivo immuno-oncology preclinical models available, and what to consider when choosing the correct model for your studies. Learn how current models are being used to progress combination regimens, including dual immunotherapies, and I/O agents plus other treatment modalities.

NEW WHITE PAPER: Translational Platforms to Model Pre-Diabetes, Diabetes, and Diabetic Complications

This White Paper explores a unique platform of highly translational models recapitulating multiple aspects of disease progression as seen in humans, for preclinical efficacy studies.

Clarity with
Crown

Recognize your next clinical candidate when you see it.

Our Translational Platforms enable our clients to identify the right patients for the right treatment. Having models which more accurately mimic human disease and population dynamics are key to successfully translating promising compounds into successful clinical candidates, whether treating Oncology or Diabetes related diseases.

Magnify your
insights

Understand the mechanisms of disease.

Our scientific acumen and experience will give you a deeper understanding of not just the pharmacological profile of your compound, but more importantly, a clear understanding of which compounds to progress into the clinic. Take a look at our publications to get a deeper understanding of the depth of our scientific expertise.

Begin with the
end insight

Connecting science to patients.

We help our clients solve some of today's most pressing problems in oncology, cardiovascular, and metabolic disease by answering some of the most challenging questions about human biology.

CVMD

Models of Obesity

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CrownBio’s preclinical Translational Technology Platforms provide spontaneous & diet-induced obesity (DIO) models, to support the transition of new agents into the clinic.

Learn More

Oncology

Oncology Databases

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Our unique databases provide a curated source of well-characterized models available to use for drug discovery including PDX models, cell lines, and syngeneic models.

Learn More

CVMD

Diabetes Models

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Models of both Type 1 and Type 2 diabetes, including conventional, as well as unique, highly translatable models for in vivo efficacy studies of antidiabetic agents.

Learn More

Latest from our Blog

February 16, 2018

3 Key Uses for Humanized Mouse Models

We’ve been focusing on humanized mouse models recently on our blog, from evolution of immunodeficient host mice through to the development of derivative hPBMC and hCD34+ HSC humanized mice. This post now takes a look at how you can combine humanized mice with human tumors for three key uses in assessing human-specific...

Read More

February 16, 2018

3 Key Uses for Humanized Mouse Models

We’ve been focusing on humanized mouse models recently on our blog, from evolution of...

Read More

February 9, 2018

X Chromosome Inactivation: New Hypothesis for Lupus Gender Disparity

It’s widely accepted that lupus occurs more often in women than men, with many studies over the...

Read More

January 30, 2018

Humanized Mouse Model Head to Head: hPBMC vs hCD34+

The future of cancer treatment is often considered to be combination regimens (dual...

Read More

January 26, 2018

Comparison Guide: huNOG® & huNSG™ Humanized Models

Previously our blog posts have reviewed humanized mice, looking at hPBMC vs hCD34+ models, how...

Read More

January 5, 2018

2018 Technology Advances – Applying Next Generation Sequencing to Single Cell Analysis

It is an axiom in biology that expression of genotype determines phenotype. This means, for the...

Read More

Upcoming Events


February 21 - 22, 2018

LabRoots Virtual Drug Discovery Event

Online, virtual Booth

www.labroots.com


March 1, 2018

Webinar: Interrogating Syngeneic Models in Large Scale, How to Use Immunoprofiling Data to Improve your Studies

Register Now


March 5 - 9, 2018

European Seminar Series: Mouse Clinical Trials and Humanised PDX to Advance Oncology Drug Discovery

London & Oxford: March 5
Stockholm: March 6
Leiden & Utrecht: March 7
Zurich: March 8
Paris: March 9

Register Now


March 15, 2018

Crown Bioscience Symposium: Perspectives on Oncology Drug Discovery; Immuno-Oncology and the Next Generation

Babraham Institute, Cambridge, UK

Register Now


March 19 - 20, 2018

5th Immunotherapy of Cancer Conference (iTOC5)

Berlin, Germany

Review our Poster Topic
www.itoc-conference.eu/itoc5-conference


April 14-18, 2018

AACR Annual Meeting 2018

Chicago, Illinois - Booth #3012

www.aacr.org