Lunch and Learn Seminar: Cutting Edge Studies in Autoimmune Disease

June 1 2018, 12-17:00pm, Queen Mary University of London: William Harvey Research Institute

Join our Lunch and Learn Seminar, hosted with Dr. Ahuva Nissim, Queen Mary University of London, to explore the latest research and developments in autoimmune disease, with cutting edge research on disorders such as ALS and MS presented by renowned academic speakers.

WEBINAR: NAFLD/NASH: Strategies for Accelerating Drug Discovery with an Improved Metabolic Dysregulation Model

June 12, 10am ET

Join our webinar supporting the 1st International NASH Day, to explore a new highly translational mouse model for NAFLD/NASH with concurrent metabolic dysregulation. Dr Judith Gorkski will present characterization and case study data showing how the FATZO mouse can accelerate the preclinical discovery of new NASH treatments. All webinar attendees will receive a free T-shirt to show your support for NASH awareness.

SYMPOSIUM: Immuno-Oncology and Inflammation; Discovering New Scientific Frontiers

June 20, 2018 - Janssen Research Campus, Beerse, Belgium

Join our inflammation and immuno-oncology symposium, jointly organized with Janssen Pharmaceutica and hosted at their research campus in Beerse, Belgium, to explore the latest developments in inflammatory and I/O molecular mechanisms, preclinical disease models, and the current research on novel therapeutic applications.

WHITE PAPER: Exploring Translational Capabilities of PDX Models across In Vivo, In Vitro, and Ex Vivo Applications

Enhance your early stage oncology and immuno-oncology drug development through expanded PDX model use. Learn more about humanized PDX for I/O studies, and explore PDX-derived cell lines and 3D PDX screening panels for in vitro/ex vivo assays, for a fully integrated preclinical research continuum.

WEBINAR: Murine Immuno-Oncology Models: A Head-to-Head Comparison Between Syngeneics and Tumor Homografts

May 23, 10am ET / May 24, 2pm ET

Presented by Dr Toni Jun, this webinar explores immunocompetent murine immuno-oncology models, with a direct comparison between syngeneics and murine tumor homografts. Learn how to choose between these model types for immuno-oncology applications, exploit model specific features and minimize limitations, as well as how to use these models to help predict patient response to immunotherapy.

Missed us at AACR 18?

Download our 13 scientific posters covering a wide variety of preclinical oncology and immuno-oncology platforms including NGS and transcriptomic PDX analysis, novel murine homograft models, as well as PBMC and humanized drug target models for immunotherapy assessment.

Save $500 on any product purchase above $2,000 in May

Fast track your preclinical oncology research with our off-the-shelf reagents, including in vivo grade antibodies and isotype controls, recombinant cell lines, biochemicals, reference standards, TMAs, kits, and more!

ON DEMAND WEBINAR: Microbiome Drug Development with Whole Communities and Defined Consortia

Presented by Dr. Joseph Maxwell of Finch Therapeutics, this webinar explores how to identify key inflammatory diseases for microbiome therapies and tailor drug development towards selected or whole community microbiota using a human-first platform. Learn more about the microbiota's role in IBD, Crohn's, and other diseases, how specific microbes drive clinical phenotypes, and novel approaches to customizing microbiome drug development.

ON DEMAND WEBINAR: Exploring Translational Capabilities of PDX Models across In Vivo, In Vitro, and Ex Vivo Applications

Presented by Dr John MacDougall, this webinar introduces the integrated use of patient-derived xenograft (PDX) models across preclinical research for more translational studies. Learn more on the importance of using highly translational preclinical cancer models, leveraging the benefits and limitations of in vitro, ex vivo, and in vivo PDX study types, and how this variety of platforms can be used for immuno-oncology studies.

ON DEMAND WEBINAR: In Vitro and Ex Vivo Assays to Accelerate Immuno-Oncology Drug Discovery

Presented by Dr Toni Jun, this webinar introduces a one stop, integrated in vitro/ex vivo I/O assay plaform designed to effciently progress immunotherapy drug development. Learn how to monitor and assess TIL populations and functions, explore the microbiome's role in immunotherapy, and understand a wide range of functional characteristics across the I/O field including tumor microenvironment regulation.

ON-DEMAND WEBINAR: Interrogating Syngeneic Models in Large Scale, How to Use Immunoprofiling Data to Improve your Studies

Presented by Dr Henry Li, this webinar explores the detailed data analysis behind the industry's first large-scale, staggered, syngeneic screening platform for immunotherapy development. Learn how this platform can improve efficiency and reproducibility while reducing cost, how comprehensive immunophenotyping and profiling data is used to address key study design questions, and how RNAseq and FACS/IHC analysis are used for biomarker discovery.

WHITE PAPER: Immuno-Oncology - 3 Strategies for Applying Humanized Models

Enhance your humanized mouse immuno-oncology studies through a deeper understanding of model immunological features and optimized uses. Learn more about immune system humanization strategies, and how these result in different models with contrasting features and limitations, then explore model applications through cancer pharmacology case studies.

Get Your Free Poster

Learn more about the world's largest patient-derived xenograft (PDX) collection. Download or request a poster today.

Watch Henry Li present EORTC 17 Short Talk

Hear Dr Henry Li, Vice President of Biomarker and Diagnostic Technology present our AACR-NCI-EORTC 2017 selected Short Talk titled 'Transcriptomic analysis of patient-derived xenografts reveals heterogeneity in human and mouse stroma/immune compartments'

ON DEMAND WEBINAR: Clinically Relevant Cell-Based Solutions for Target Identification

Learn how to leverage CrownBio's integrated Oncology Portfolio to advance your Target Identification studies. Watch our webinar presented by Michelle Mack.

NEW WHITE PAPER: The Ultimate Guide to Mouse Clinical Trials

Transform your preclinical oncology drug development, with mouse clinical trials using patient-derived xenograft (PDX) models. Learn how the different types of MCT are executed, which is the best fit for your specific drug discovery program, and how they provide the perfect framework for biomarker discovery.

ON DEMAND WEBINAR: How to Maximize Your Non-GLP Toxicology Studies: A Guide for Optimal Design and Methodology

Presented by Dr. Keefe Chng and Dr Judith Gorski this webinar will help guide you through a study design process that will enable the greatest opportunity to generate robust, high-quality data, that gives maximum confidence to select new drug candidates and regulatory submissions.

NEW WHITE PAPER: Translational Platforms to Model Pre-Diabetes, Diabetes, and Diabetic Complications

This White Paper explores a unique platform of highly translational models recapitulating multiple aspects of disease progression as seen in humans, for preclinical efficacy studies.

Clarity with
Crown

Recognize your next clinical candidate when you see it.

Our Translational Platforms enable our clients to identify the right patients for the right treatment. Having models which more accurately mimic human disease and population dynamics are key to successfully translating promising compounds into successful clinical candidates, whether treating Oncology or Diabetes related diseases.

Magnify your
insights

Understand the mechanisms of disease.

Our scientific acumen and experience will give you a deeper understanding of not just the pharmacological profile of your compound, but more importantly, a clear understanding of which compounds to progress into the clinic. Take a look at our publications to get a deeper understanding of the depth of our scientific expertise.

Begin with the
end insight

Connecting science to patients.

We help our clients solve some of today's most pressing problems in oncology, cardiovascular, and metabolic disease by answering some of the most challenging questions about human biology.

CVMD

Models of Obesity

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CrownBio’s preclinical Translational Technology Platforms provide spontaneous & diet-induced obesity (DIO) models, to support the transition of new agents into the clinic.

Learn More

Oncology

Oncology Databases

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Our unique databases provide a curated source of well-characterized models available to use for drug discovery including PDX models, cell lines, and syngeneic models.

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CVMD

Diabetes Models

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Models of both Type 1 and Type 2 diabetes, including conventional, as well as unique, highly translatable models for in vivo efficacy studies of antidiabetic agents.

Learn More

Latest from our Blog

May 24, 2018

Webinar FAQ: Humanized PDX Models in Immuno-Oncology

Patient-derived xenografts (PDX) support highly translational preclinical oncology research, but were historically ill-suited for the assessment of most immunotherapeutics. Humanized PDX models bridge this gap by enabling immuno-oncology (I/O) studies in the context of a functional immune system.

Read More

May 24, 2018

Webinar FAQ: Humanized PDX Models in Immuno-Oncology

Patient-derived xenografts (PDX) support highly translational preclinical oncology research, but...

Read More

May 22, 2018

Immuno-Oncology and the Microbiome at AACR 2018

CrownBio presented thirteen posters at AACR 2018, sharing our latest internal research into ...

Read More

May 17, 2018

Genetically Engineered or Syngeneic Mouse Models?

Mouse models are a mainstay of preclinical cancer research, and immunocompetent model use is...

Read More

May 15, 2018

Murine Homograft Tumor Models at AACR 2018

We presented a wide range of immuno-oncology model data at AACR 2018, with three of our thirteen...

Read More

May 10, 2018

In Vitro and Ex Vivo Assay Platforms at AACR 2018

We presented a wide range of oncology modelling capabilities at AACR 2018, spanning the breadth...

Read More

Upcoming Events


May 23 - 24, 2018

Webinar: Murine Immuno-Oncology Models: A Head-to-Head Comparison Between Syngeneics and Tumor Homografts

Register Now


May 24 - 25, 2018

3rd Annual Advances in Immuno-Oncology Congress

London, UK

Preview our Poster Topic
www.immunooncology-congress.com


June 1, 2018

Lunch and Learn Seminar: Cutting Edge Studies in Autoimmune Disease

London, UK

Register Now


June 1 - 5, 2018

ASCO Annual Meeting

Chicago, IL

Arrange a Meeting
www.am.asco.org


June 9, 2018

2018 CBA Annual Conference

Gaithersburg, MD

Preview Poster Topic
http://www.cba-usa.org/cba-annual-conference


June 12, 2018

Webinar: NAFLD/NASH: Strategies for Accelerating Drug Discovery with an Improved Metabolic Dysregulation Model

Register Now


June 20, 2018

Symposium: Immuno-Oncology and Inflammation; Discovering New Scientific Frontiers

Janssen Research Campus, Beerse, Belgium

Register Now


June 21 - 22, 2018

Next Gen Immuno-Oncology Congress

Philadelphia, PA

www.mnmconferences.com


June 22 - 26, 2018

American Diabetes Association 78th Scientific Sessions

Orlando, FL - Booth #1615

Preview our Poster Topics
www.professional.diabetes.org


June 30 - July 3, 2018

EACR25: 25th Biennial Congress of the European Association for Cancer Research

Amsterdam, Netherlands

Preview Poster Topic
www.eacr25.org