SYMPOSIUM: Inflammatory Bowel Disease from Bench to Bedside

December 13 2017, Boston Marriott Cambridge, Cambridge, MA

Attend our inaugural symposium focusing on the latest preclinical advances in IBD. The symposium will dive into the most relevant topics that are pertinent to this rapidly moving environment. Key discussion topics include gene regulation and the involvement in mucosal inflammation and new strategies for IBD preclinical development.

Watch Henry Li present EORTC 17 Short Talk

Hear Dr Henry Li, Vice President of Biomarker and Diagnostic Technology present our AACR-NCI-EORTC 2017 selected Short Talk titled 'Transcriptomic analysis of patient-derived xenografts reveals heterogeneity in human and mouse stroma/immune compartments'

WEBINAR: Clinically Relevant Cell-Based Solutions for Target Identification

Wednesday, November 16 10:00am EDT

Learn how to leverage CrownBio's integrated Oncology Portfolio to advance your Target Identification studies. Attend our webinar presented by Michelle Mack.

ON DEMAND WEBINAR: Mouse Clinical Trials: The Power Behind Study Design

Presented by Dr Sheng Guo this webinar covers the key aspects of how to design PDX Mouse Clinical Trials to fully address the key questions in drug discovery programs. Learn how: to select the optimal number of models and mice for your study, to quantify and evaluate your drug’s efficacy, and to use MCT data to leverage biomarker discovery.

ON DEMAND WEBINAR: Beyond Syngeneics – Novel Tools for Addressing Human Specificity in Immuno-Oncology

Presented by Michelle Mack this webinar presents novel humanized drug target models (e.g. for PD-1, CTLA-4, PD-L1) for investigating human specificity in immunocompetent mice, and evauating human-specific immuno-oncology agents in vivo.

NEW WHITE PAPER: The Ultimate Guide to Mouse Clinical Trials

Transform your preclinical oncology drug development, with mouse clinical trials using patient-derived xenograft (PDX) models. Learn how the different types of MCT are executed, which is the best fit for your specific drug discovery program, and how they provide the perfect framework for biomarker discovery.

Didn't Make it to AACR-NCI-EORTC International Conference 2017?

Read and download all of our 13 posters now!

Missed us at the AACR New Horizons in Cancer Research Conference?

Read and download all of our 12 posters now!

ON DEMAND WEBINAR: The Ultimate Guide to Mouse Clinical Trials

Presented by Dr. John MacDougall this webinar presents Mouse Clinical Trials (MCT) using PDX models, and will help to guide you through the process of determining which MCT best suits the specific needs of any given drug development program.

NEW WHITE PAPER: A Guide to Selecting Your Next Immuno-Oncology Model

Improve your model selection decision for any immuno-oncology study by exploring the immunocompetent model types within this white paper. Learn more about the features, limitations and major uses of each type and how to apply them to your next study.

High Fidelity CRISPR Cell Line Engineering Services

Make better go/no-go decisions with CRISPR Engineered Cell Line Services.

CrownBio provides efficient, cost-effective gene editing services using licensed CRISPR/Cas9 technology. Our experts can generate knock in and knockout cell lines with vector controls that are tailored to meet your specific needs and help you advance your preclinical drug development programs.

Missed the Third CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference?

Poster: Humanized CD137 Models for Preclinical Drug Development

Preclinical Efficacy Evaluation of Agonistic CD137 Therapeutic Antibodies in Human CD137 Knock-In Mouse Models (HuGEMM™)

ON DEMAND WEBINAR: How to Maximize Your Non-GLP Toxicology Studies: A Guide for Optimal Design and Methodology

Presented by Dr. Keefe Chng and Dr Judith Gorski this webinar will help guide you through a study design process that will enable the greatest opportunity to generate robust, high-quality data, that gives maximum confidence to select new drug candidates and regulatory submissions.

ON DEMAND WEBINAR: Vascular and Neural Complications in Rodent Models of Obesity and Type 2 Diabetes

Watch this scientific webinar presented by Dr. Mark Yorek, Professor of Medicine at University of Iowa and Associate Chief of Staff for Research at Iowa City VA. He will discuss the challenges in modeling diabetic neuropathy and how the use of improved translational rodent models can impact Diabetes and Obesity pre-clinical studies.

ON-DEMAND WEBINAR: Are You Choosing the Right Model?

A Guide to Selecting Your Next Immuno-Oncology Model

Join our webinar to discover the wide range of in vivo immuno-oncology preclinical models available, and what to consider when choosing the correct model for your studies. Learn how current models are being used to progress combination regimens, including dual immunotherapies, and I/O agents plus other treatment modalities.

NEW WHITE PAPER: Translational Platforms to Model Pre-Diabetes, Diabetes, and Diabetic Complications

This White Paper explores a unique platform of highly translational models recapitulating multiple aspects of disease progression as seen in humans, for preclinical efficacy studies.

Clarity with
Crown

Recognize your next clinical candidate when you see it.

Our Translational Platforms enable our clients to identify the right patients for the right treatment. Having models which more accurately mimic human disease and population dynamics are key to successfully translating promising compounds into successful clinical candidates, whether treating Oncology or Diabetes related diseases.

Magnify your
insights

Understand the mechanisms of disease.

Our scientific acumen and experience will give you a deeper understanding of not just the pharmacological profile of your compound, but more importantly, a clear understanding of which compounds to progress into the clinic. Take a look at our publications to get a deeper understanding of the depth of our scientific expertise.

Begin with the
end insight

Connecting science to patients.

We help our clients solve some of today's most pressing problems in oncology, cardiovascular, and metabolic disease by answering some of the most challenging questions about human biology.

CVMD

Models of Obesity

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CrownBio’s preclinical Translational Technology Platforms provide spontaneous & diet-induced obesity (DIO) models, to support the transition of new agents into the clinic.

Learn More

Oncology

Oncology Databases

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Our unique databases provide a curated source of well-characterized models available to use for drug discovery including PDX models, cell lines, and syngeneic models.

Learn More

CVMD

Diabetes Models

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Models of both Type 1 and Type 2 diabetes, including conventional, as well as unique, highly translatable models for in vivo efficacy studies of antidiabetic agents.

Learn More

Latest from our Blog

November 10, 2017

EORTC 2017 Short Talk Review

Transcriptomic Analysis of Patient-Derived Xenografts Reveals Heterogeneity in Human and Mouse Stroma/Immune Compartments

It is being increasingly recognized that cancers are more than just genetic diseases, they are also diseases of immunological abnormalities. Research has therefore focused on both cancer genomics as well as...

Read More

November 10, 2017

EORTC 2017 Short Talk Review

Transcriptomic Analysis of Patient-Derived Xenografts Reveals Heterogeneity in Human and Mouse...

Read More

November 8, 2017

Humanized Mouse Clinical Trials for Immunotherapy Development

Recent posts have covered the different types of mouse clinical trial (MCT) and which is most...

Read More

November 3, 2017

Using PDX as Surrogate Models for TME Investigation

The diversity of cancers is due to the fact that there are numerous different types, along with...

Read More

October 31, 2017

How to Choose the Right Type of Mouse Clinical Trial

As covered in our recent blog post, Mouse Clinical Trials using patient-derived xenograft (PDX)...

Read More

October 26, 2017

Post FDA Approval: CAR-T Therapy Key Facts

A few weeks ago, the FDA issued a historic approval of the first cancer cell therapy using a...

Read More

Upcoming Events


November 15 - 17, 2017

2nd Annual World Preclinical Congress

Lisbon, Portugal

www.worldpreclinicaleurope.com
Review our Scientific Poster


December 4, 2017

Northwest Gynecological Cancer Symposium

Seattle, WA

www.rivkin.org/ngcs
Review our Scientific Poster


December 5 - 7, 2017

Tumor Models, London

London, UK

www.tumour-models.com
Review our Presentation & Poster


December 9 - 10, 2017

59th Annual ASH Meeting

Atlanta, GA

www.hematology.org


December 13, 2017

Crown Bioscience Symposium: Inflammatory Bowel Disease from Bench to Bedside

Boston Marriott Cambridge, Cambridge, MA

Review Speakers and Register