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WEBINAR: Animal Model Selection, Study Design, and Current Trends in Preclinical Obesity Research

Wednesday September 30th, 11:00am EDT

Join Dr Fred Beasley to learn more about the key factors to consider when choosing the right rodent model for preclinical obesity studies. Explore how to establish study aims for obesity research, the conventional and next generation obesity models available, and best practice in study design.

NEW PUBLICATION: Barcode Deep NGS-Based Profiling of Oncology Samples

Learn how a barcode deep NGS-based method enables highly sensitive characterization of cell lines, xenografts, organoids, and patient samples. Discover how this novel and robust method is used to determine identity, detect contamination, and annotate mouse and human samples.

WEBINAR: Next Generation Syngeneic Models to Facilitate Immuno-Oncology Research

Thursday September 24 - 9am/1pm ET

Join Dr Davy Ouyang to discover the latest cutting edge syngeneic research driving immuno-oncology development. Learn more about deep kinetic profiling, and how immune cell depletion studies are used to explore mediation of immunotherapy response. Engineered and bioluminescent syngeneics will also be discussed, as well as novel I/O platforms for moving beyond standard syngeneic studies.

NEW WHITE PAPER: Learn When and How to Use Tumor Organoids in Oncology Drug Discovery

Learn how to select the right in vitro platform for each stage of your drug development program based on model features, benefits, and limitations. Explore the optimal applications of tumor organoids, a superior and predictive research system for oncology drug development, and how to best utilize them alongside conventional platforms.

Keeping Your Projects Moving During the

COVID-19 Pandemic

Read the update from Dr. Jean-Pierre Wery, CEO on how we're balancing our operations while keeping our staff and facilities safe. Find out more about our current global capacity - with all China sites fully operational, and a Proxy SD system for EU/US affected areas

ON DEMAND WEBINAR: In Silico Applications for In Vitro Drug Discovery

Join Dr Sheng Guo to learn how to maximize your oncology in vitro datasets using in silico modeling. Find out how advanced data analysis is used to interrogate cell line and organoid genomics, novel combination regimens, and predictive biomarkers.

NEW WHITE PAPER: Discover the Benefits of Biomarker Discovery in Early-Stage Drug Development

Explore three strategies for biomarker discovery and validation early in oncology drug development. Learn how translational preclinical models are used to identify and implement biomarkers across a range of studies, and how to transfer preclinical biomarkers to the clinic for improved accuracy and success rates.

ON DEMAND WEBINAR: Tumor Organoids: A Paradigm Shift in Oncology Drug Discovery

Join Dr Henry Li, CrownBio CSO and Dr Sylvia Boj, HUB Scientific Director to learn more about HUB tumor organoids and their applications in oncology drug discovery. Find out why organoids better predict patient response, and how they are used to improve cancer drug candidates entering the clinic.

WHITE PAPER: Optimizing Translational IBD Capabilities How to Select the Right Preclinical Model

Explore the key features of commonly used preclinical IBD models, including model development and example treatment studies. Learn how to choose the most appropriate model for your drug development program, based on drug target and mechanism of action alongside model disease pathogenesis and clinical relevance.

ON DEMAND WEBINAR: Identifying Preclinical Immunotherapy Candidates Using a NHP Exploratory Toxicology Platform

Join Dr Thomas Scullion to learn how to leverage NHP exploratory toxicology studies to guide and answer multiple immunotherapy developmental questions including lead optimization, dosing paradigms, and immunogenicity endpoints. Discover how NHPs provide a more translational preclinical model for elucidating immune-related toxicity.

CVMD

Models of Obesity

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CrownBio’s preclinical Translational Technology Platforms provide spontaneous & diet-induced obesity (DIO) models, to support the transition of new agents into the clinic.

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Oncology

Oncology Databases

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Our unique databases provide a curated source of well-characterized models available to use for drug discovery including PDX models, cell lines, and syngeneic models.

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CVMD

Diabetes Models

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Models of both Type 1 and Type 2 diabetes, including conventional, as well as unique, highly translatable models for in vivo efficacy studies of antidiabetic agents.

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Latest from our Blog

September 22, 2020

T Cell Dysfunction Assays for In Vitro Screening of Immunomodulatory Drug Candidates

Review the latest advances in the recall antigen assay, to provide an optimized system for screening and characterizing immunomodulatory drug candidates, including recapitulating aspects of a suppressed tumor microenvironment (TME).

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September 22, 2020

T Cell Dysfunction Assays for In Vitro Screening of Immunomodulatory Drug Candidates

Review the latest advances in the recall antigen assay, to provide an optimized system for...

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September 17, 2020

HUB Technology: The Only Tumor Organoid Platform Available for Oncology Drug Discovery

Explore why adult stem cell (ASC)-derived HUB technology provides the only tumor organoid...

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September 15, 2020

Targeting Peroxisome Proliferator-Activated Receptors for NASH Therapy

Review the roles of peroxisome proliferator-activated receptor (PPAR) isotypes in managing...

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September 10, 2020

Genome-Wide RNAseq and Array-Based NanoString Transcriptomic Technologies: Which To Use and When?

Compare the pros and cons of two widely used transcriptomic technologies - genome-wide RNAseq...

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September 8, 2020

Targeting the Fibroblast Growth Factor Axis for NASH Therapy

Review the roles of members of the FGF19 subclass of fibroblast growth factor (FGF) hormones in...

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Upcoming Events


September 24, 2020

WEBINAR: Next Generation Syngeneic Models to Facilitate Immuno-Oncology Research

9am/1pm ET


September 30, 2020

WEBINAR: Animal Model Selection, Study Design, and Current Trends in Preclinical Obesity Research

11:00am EDT


October 14, 2020

Virtual Lunch and Learn: Translational Preclinical Platforms for CAR-T Cell Therapy

12-1:00pm BST


October 15-16, 2020 | PDT (UTC-7)

Biomarkers Series US

Virtual


October 24-25, 2020

32nd EORTC-NCI-AACR Symposium

Virtual