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WEBINAR: Reversing Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic NHPs with a Controlled-Release Mitochondrial Protonophore (CRMP)

Thursday February 6, 10:30am/10:30pm EST

Presented by Dr Leigh Goedeke, Yale School of Medicine this webinar details using spontaneous NHP models of NAFLD and metabolic syndrome to assess a controlled-release mitochondrial protonophore (CRMP). Explore proof-of-concept data from these clinically relevant models, supporting the development of novel liver-targeted mitochondrial uncouplers to treat human NASH and T2D.

NEW WHITE PAPER: Applications of HUB Tumor Organoids in Oncology Drug Development

Learn more about PDX-derived tumor organoids (PDXO) developed using HUB protocols, as robust in vitro models to improve the predictivity and speed of preclinical drug discovery. Review the main applications of 3D PDXO including large-scale drug screening, in vivo model selection, and in silico drug discovery.

WEBINAR: 3 Strategies to Identify Clinically Predictive Biomarkers in the Preclinical Space

January 15th, 2020 10am/4pm/10pm ET

Join Mike Batey to learn how to apply systems biology in early stage drug development for biomarker discovery and validation. Review 3 case studies exploring novel strategies to identify and utilize biomarkers using translational preclinical models, including using in vitro models to uncover genetic signatures of response and in vivo PDX to dissect drug MoA and guide clinical trial design.

ON DEMAND WEBINAR: Demonstrating Clinical Relevance in 3D In Vitro Modeling with HUB Organoids

Presented by Dr Sylvia Boj, Hubrecht Organoid Technology this webinar reviews the development and application of HUB Organoids. Explore the many advantages of HUB Organoids within 3D in vitro modeling, including direct clinical relevance and immuno-oncology applications.

NEW WHITE PAPER: How to Assess Immunotherapy Toxicity using NHPs

Learn more about NHPs as a valuable early-stage preclinical platform for non-GLP exploratory toxicology studies. Explore the robust data these studies generate in a rapid, flexible, and cost-effective manner to assess immunotherapy safety and de-risk future clinical trials.

NEW WHITE PAPER: Unlock the Full Power of MCTs through Advanced Statistical Analysis

Learn how to optimize PDX mouse clinical trial design, use, and data output by moving beyond traditional analyses to a robust statistical framework. Explore case studies applying our published linear mixed models to enhance MCT study design, drug efficacy quantification, biomarker discovery and validation, as well as reinterpretation of clinical trial results.

NEW WHITE PAPER! HUB Organoid Technology: Advantages in 3D In Vitro Modeling

Review the breakthrough discoveries leading to the development of HUB Organoids. Explore the key features of these 3D in vitro models including organ morphology recapitulation, stability, genomic superiority, and long-term culture, as well as their main utilities in research and development.

WHITE PAPER: Optimizing Translational IBD Capabilities How to Select the Right Preclinical Model

Explore the key features of commonly used preclinical IBD models, including model development and example treatment studies. Learn how to choose the most appropriate model for your drug development program, based on drug target and mechanism of action alongside model disease pathogenesis and clinical relevance.

ON DEMAND WEBINAR: Preclinical Obesity Research: Best Practice in Model Selection and Study Design

Presented by Dr Fred Beasley this webinar explores how to select the most appropriate models for your preclinical obesity studies, including polygenic vs monogenic models and recommendations based on drug modes of action. We also review best practice in obesity study design to maximize data outcomes.

CVMD

Models of Obesity

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CrownBio’s preclinical Translational Technology Platforms provide spontaneous & diet-induced obesity (DIO) models, to support the transition of new agents into the clinic.

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Oncology

Oncology Databases

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Our unique databases provide a curated source of well-characterized models available to use for drug discovery including PDX models, cell lines, and syngeneic models.

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CVMD

Diabetes Models

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Models of both Type 1 and Type 2 diabetes, including conventional, as well as unique, highly translatable models for in vivo efficacy studies of antidiabetic agents.

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Latest from our Blog

January 17, 2020

The Link Between Diabetes and Kidney Disease

Learn more about the link between diabetes and kidney disease, including three main ways that hyperglycemia negatively impacts renal health, and how diabetic kidney disease can be modeled preclinically.

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January 17, 2020

The Link Between Diabetes and Kidney Disease

Learn more about the link between diabetes and kidney disease, including three main ways that...

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January 16, 2020

How Are Organoids Different from 3D Primary Cell Cultures?

Explore the key differences between organoids and primary cells grown in 3D, from both healthy...

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January 9, 2020

How to Use Tumor Organoids for Oncology Drug Screening

Review how, and why, to use tumor organoids in in vitro oncology drug screening programs.

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December 3, 2019

Top 12 Questions: Applications of PDXO

Review the top 12 questions on PDX-derived organoid (PDXO) utilities from our recent webinar,...

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Upcoming Events


January 22-24, 2020

4th PREDiCT: Tumor Models San Francisco

San Francisco, CA


February 6, 2020

Webinar: Reversing Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic NHPs with a Controlled-Release Mitochondrial Protonophore (CRMP)


February 6-7, 2020

5th Annual Markets and Markets Biomarker and Companion Diagnostics Conference

San Diego, CA


February 10-11, 2020

Global NASH Congress

London, UK


February 18-19, 2020

Precision Medicine and Immuno-Oncology China 2020

Shanghai, China