Rheumatoid Arthritis

Progress your RA Agent Drug Development with our In Vivo Preclinical Models

Utilize preclinical models with diverse mechanisms capturing key characteristic clinical and pathological RA features to determine efficacy and response to treatment, and improve selection of your next qualified RA lead agent. Choose from the:

• Collagen antibody-induced arthritis mouse model
• Collagen-induced arthritis mouse model

Collagen Antibody-Induced Arthritis (CAIA) Mouse Model

RA is induced through administration of commercially available antibodies targeting Type II collagen and results in rapid onset of disease.

Collagen-Induced Arthritis (CIA) Mouse Model

DBA/1 mice are immunized with Type II collagen and boosted with IFA. Peak disease occurs 8-15 days post IFA boost.

Major Endpoints

• Swollen joint count
• Assessment of inflammatory mediators/cytokines
• Histopathological assessment

CAIA Model + Dexamethasone

Representative Forepaw Histology Photomicrographs

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Non-lesioned paw. A distal phalangeal bone (P), carpal bone (C), and proximal interphalangeal joint (J) are indicated.

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Marked inflammation (*) of the intra- and peri-articular tissues, affecting the interphalangeal joints (phalangeal bone, P) and carpal (C) joints is noted. Cartilage damage (black arrows), bone resorption (black arrowheads), pannus (blue arrowheads), and periosteal new bone (NB) are indicated.

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Forepaw lacks lesions associated with arthritis. Interphalangeal joint (J), proximal phalangeal bone (P), and carpal bone (C) are indicated.