<img height="1" width="1" src="https://www.facebook.com/tr?id=1582471781774081&amp;ev=PageView &amp;noscript=1">

HuGEMM™

Study human-specific immuno-oncology therapeutics in vivo

Robust Humanized Target Model Platform for Immunotherapy Evaluation

The preclinical evaluation of immunotherapies has been hindered by a lack of in vivo models for testing human-specific therapeutics. Surrogate anti-mouse checkpoint inhibitors were initially evaluated in syngeneics, however these models cannot be used for testing human biological therapeutics due to species specificity issues.

To study human specific biological therapies in vivo, we’ve developed the HuGEMM platform. HuGEMM models feature a humanized drug target (e.g. checkpoint inhibitors) within mice with a functional immune system.

  • Efficiently study a range of targets for human immunotherapies
  • Evaluate human specific biological therapies in vivo when no mouse ortholog is available
  • Save study resources by using this cost-efficient alternative to more complex, fully-humanized models

What is a HuGEMM?

HuGEMM are immunocompetent chimeric mouse models, engineered to express humanized drug targets such as genes encoding for immune checkpoint proteins.

Available HuGEMM Models

 
Single Knock-in Double Knock-in Triple Knock-in Quadruple Knock-in
B7H3 TIGIT/PVR CD3EDG PD-1/ICOS/LAG-3/CTLA-4
BTLA PD-L1/TIM-3 CD47/Sirpα/PD-1  
CCR2 PD-L1/TIGIT CD47/Sirpα/PD-L1  
CCR8 PD-L1/OX40 PD-1/PD-L1/CD137  
CD137 PD-L1/LAG3 PD-1/PD-L1/CTLA4  
CD20 PD-L1/CTLA4 PD-1/PD-L1/IDO-1  
CD27 PD-L1/CD47 PD-1/PD-L1/LAG-3  
CD28 PD-L1/CD40 PD-1/PD-L1/OX40  
CD38 PD-L1/CD27 PD-1/PD-L1/TIGIT  
CD3E PD-L1/CD137 PD-1/PD-L1/TIM-3  
CD40 PD-1/Tim3 PD-1/TIM-3/TIGIT  
CD47 PD-1/TIGIT    
CD73 PD-1/Sirpα    
CSF1R PD-1/PD-L1    
CTLA4 PD-1/OX40    
GITR PD-1/LAG3    
IL-1b PD-1/GITR    
LAG3 PD-1/CTLA4    
OX40 PD-1/CD47    
OX40L PD-1/CD40    
PD-1 PD-1/CD28    
PD-L1 PD-1/CD27    
SIGLEC15 PD-1/CD137    
Sirpα PD-1/BTLA    
STING OX40/CD137    
TIGIT NKG2A/CD94    
TIM-3 IL2RA/IL2    
TLR8 CTLA4/Tim3    
TNFR2 CTLA4/OX40    
VEGFR2 CTLA4/LAG3    
VISTA CTLA4/CD137    
  CD3/TPBG    
  CD47/Sirpα    
  CD40/CD137    
  CD27/CD137    
  CSF1R/PD-1    
  CSF1R/PD-L1    

Explore Our Collection



Discuss Your Humanized Target Project

Tell us how we can help