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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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Nanostring Spatial Transcriptomics and Proteomics Services

Certified CRO services with GeoMx® Digital Spatial Profiling

Crown Bioscience offers a comprehensive solution for spatial profiling using the advanced NanoString's GeoMx® platform. Our approach employs morphologically guided gene expression, utilizing NanoString's expertly crafted panels. The process is streamlined for our clients: simply provide your tissue samples, select the desired NanoString panel and readout method, and let our professionals manage everything else. Experience the next level of tissue profiling with ease!

GeoMx® DSP: A Flexible & Scalable Platform for Spatial Biology

Efficiently address tissue diversity and intricate micro-environments using the GeoMx Digital Spatial Profiler (DSP), the premier spatial multiomic platform designed for both FFPE and fresh frozen tissue analysis. Unique in its field, the GeoMx facilitates non-destructive RNA and protein expression profiling from specific tissue sections and cell groups, all through an automated, scalable workflow compatible with conventional histology staining processes.

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Profile the Whole Transcriptome and 570+ Proteins from Intact Tissue

Explore the complete transcriptome and over 570 protein targets individually or in tandem, utilizing a range of sample inputs including whole tissue sections, tissue microarrays (TMAs), or organoids. Choose GeoMx DSP as your trusted platform in spatial biology for unveiling biomarkers and conducting hypothesis testing.

What Can You Do with GeoMx DSP?

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Imagine the Possibilities with GeoMx DSP



How It Works


Empower Your Research with Biology-Driven Profiling

With our system, the tissue becomes your compass, guiding you to select crucial tissue microenvironments and cell types. Utilize fluorescent staining patterns to precisely segment and profile specific areas. Our adaptable region of interest (ROI) strategies, rooted in tissue morphology, ensure accurate profiling of your chosen compartments or cell groups. Throughout this process, our dedicated spatial multiomics team is on hand, collaborating closely with you to guide ROI selection and address any queries.


GeoMx RNA and Protein Assays Overview

RNA Assays

  • Human/Mouse Whole Transcriptome Atlas (WTA): Facilitates extensive spatial biology profiling, covering all protein-coding genes.

    Download Details of Human WTA
    Download Details of Mouse WTA
  • TCR Profiling Add-On: Can be added to the Whole Transcriptome or Cancer Transcriptome Atlases to analyze different T Cell Receptor (TCR) expressions spatially.
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  • Cancer Transcriptome Atlas: Aimed at detailed tumor biology profiling, enabling the analysis of over 1,800 genes from distinct regions in a single tissue section.

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  • Spatial RNA Panel for Immuno-oncology: Focuses on targeted profiling of the tumor and its surroundings, allowing for the analysis of up to 96 RNA targets in a single tissue section using GeoMx DSP.

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GeoMx IO Proteome Atlas

Dive into the next level of immuno-oncology research with the GeoMx IO Proteome Atlas (IPA), backed by Abcam's IHC-validated human antibodies. This leading spatial proteomics panel excels in analyzing both FFPE and fresh frozen tissue sections, opening new avenues for biomarker discovery in translational research.

The GeoMx IPA stands out by offering:

  • Non-destructive profiling of over 570 proteins in various tissue areas.
  • Superior data richness compared to traditional IHC or IF assays.
  • Compatibility with standard histology workflows.

Take advantage of this technology to gain a deeper understanding of vital tissue microenvironments and cell types, enhancing your insights into immune responses to cancer and potential therapeutic strategies in immunology, oncology, and other research fields.

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Protein Assays (nCounter Readout)

  • Immuno-Oncology and Immunology: Features a core of 18 targets (17 for mouse) for wide-ranging cell profiling, with the flexibility to add up to 60 additional targets plus 10 custom selections for tailored research.

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  • Neuroscience: Comes with a core of 20 targets (19 for mouse) for broad cell profiling, and offers the ability to add up to 60 more targets plus 10 custom selections for specific research need

    Download Details

Reports and Data Analysis

The GeoMx® Data Analysis Suite (DSPDA) offers an integrated platform that seamlessly links quantitative data with its spatial context, ensuring an efficient experimental workflow. Our team of Bioinformatics experts not only reviews the QC data from each project but also furnishes a comprehensive overview via a Standard Report. Should you require a deeper dive into your data, we're available for personalized consultations to cater to your specific analytical needs.

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Spatial Multiomics Services with NanoString GeoMx DSP platform Image
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NanoString DSP vs. 10x Genomics Visium: A Comparative Study in Spatial Transcriptomics for Cancer Research Image
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Screen Hundreds of TMA Samples at a Time for Biomarkers of Interest Image
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