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thumb-odw-cart-cell-therapies Watch Now On-Demand Webinar How to Detect, Characterize, and Evaluate CAR-T Cell Therapies CAR-T cell therapy is a rapidly advancing I/O treatment approach, genetically modifying a..
thumb-qf-pdxo Read More Quick Fact PDX-Derived Organoids (PDXO) PDXO models, developed using Hubrecht Organoid Technology (HUB) protocols, offer a rapid, cost..
thumb-publication-crmp-safety-efficacy-nhp Read More Publication CRMP Safety and Efficacy Confirmed in Clinically-Relevant NHP Models The Shulman Lab at Yale University has developed a controlled-release mitochondrial protonophore..
thumb-qf-cytokine-chemokine Read More Quick Fact Cytokine and Chemokine Profiling Rapidly quantify bioactive proteins via high throughout profiling
thumb-qf-histology-digital-pathology Read More Quick Fact Histology and Digital Pathology Accurately visualize drug effect through next generation IHC and IF
thumb-publication-car-t-cell-gastric-cancer Read More Publication Assessing CAR-T Cell Therapy for Gastric Cancer with PDX Models Despite advances in gastric cancer treatment and surgical techniques, overall survival rates for..
thumb-pub-pancreatic-beta Read More Publication Pancreatic Beta Cell Dysfunction and Diabetes Progression in NHP Models NHPs with spontaneously occurring type 2 diabetes provide the preclinical model most closely..
thumb-odw-obesity-research Watch Now On-Demand Webinar Preclinical Obesity Research: Best Practice in Model Selection and Study Design Preclinical obesity research and drug development is complex and challenging.
thumb-poster-128-dot19 Read More Poster DoT Poster: New CDAHFD-Induced, Dysmetabolic NASH ZDSD Rat Model The ZDSD Rat, a Dysmetabolic Model with Intact Leptin Pathway, Develops NAFLD and NASH when Fed..
thumb-qf-biomarker-services Read More Quick Fact Biomarker Services Proteomic and genomic assays to uncover biomarkers of response
thumb-wp-hub-organoid-technology Read More White Paper Advantages in 3D In Vitro Modeling with HUB Organoids Organoids, or “mini organs” in a dish, have recently been developed after many decades of..
thumb-odw-hub-organoids Watch Now On-Demand Webinar Demonstrating Clinical Relevance in 3D In Vitro Modeling with HUB Organoids Organoid technology has enormous potential for oncology research and anticancer agent drug..
thumb-webinar-crmp Watch Now On-Demand Webinar Reversing Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic NHPs with.. NAFLD is a major predisposing factor in the pathogenesis of hepatic insulin resistance, NASH,..
thumb-toxicity-using-nhps Read More White Paper Identifying Immune-Related Toxicity with Non-GLP Exploratory NHP Toxicology.. The safety of immunotherapies is a major clinical concern which needs to be addressed early in..
thumb-type1-diabetes Read More Quick Fact Type 1 Diabetes Models Progress your antidiabetic agents with spontaneous and accelerated T1D models
thumb-peritonitis-models Read More Quick Fact Peritonitis Models Increase your study confidence using validated in vivo models
thumb-wp-stress-free-nhp Read More White Paper Novel Stress-Free Technologies to Optimize NHP Study Data NHPs are the most clinically relevant preclinical model for T2D research.
thumb-bmc-cancer Read More Publication How to Design, Apply, and Use Mouse Clinical Trials Mouse clinical trials (MCTs) employ panels of preclinical models in population-based efficacy..
thumb-event-steptozocin Read More Publication Diabetogenic Effects of Steptozocin in NHPs Streptozocin (STZ) is commonly used for diabetic induction in animal models due to its high..
thumb-publication-new-nafld-nash Read More Publication New NAFLD/NASH Mouse Model with Concurrent Metabolic Dysregulation Metabolic disorders, including insulin resistance, obesity, and hyperglycemia, are prominent..
resources-video-thumb-nhps Watch Now On-Demand Webinar Assessing Immunotherapy Toxicity in NHPs Understand the NHP model features that provide an ideal preclinical model for elucidating..
thumb-wp-preclinical-oncology Read More White Paper Imaging Orthotopic and Metastatic Preclinical Tumor Models Orthotopic models provide a more predictive alternative, allowing establishment of a relevant..
thumb-odw-nafld-nash Watch Now On-Demand Webinar Overcoming Challenges in NAFLD/NASH Preclinical Modeling While the race for the first clinical NASH approval intensifies, preclinical research continues..
thumb-ada-303-lb Read More Poster Poster 303-LB: New Accelerated and Exacerbated NASH Fibrosis Preclinical Model Accelerated Hepatic Fibrosis in Western Diet-Fed Non-Alcoholic Steatohepatitis Mice Model by..
thumb-ada-1998-p Read More Poster Poster 1998-P: NAFLD/NASH Induction in a Dysmetabolic Model using High.. Progressive Liver Dysfunction Resulted from a High-Fat, High-Fructose Diet in MS-NASH (FATZO)..
thumb-wp-ibd-models Read More White Paper Choosing and Implementing the Most Appropriate IBD Model There is a vast array of preclinical inflammatory bowel disease (IBD) models, each with their..
thumb-wp-pancreatic-cancer Read More White Paper Advanced Models and Novel I/O Technologies for Preclinical PDAC Research Pancreatic cancer is a challenging disease due to resistance to a range of anticancer agents and..
thumb-jax-roadshow19 Watch Now Presentation The Jackson Laboratory’s Metabolic Disease Roadshow Presentation – Dr. Jim Wang The MS-NASH mouse (previously called FATZO) provides a more translatable preclinical model for..
wp-mazimize-io-translatability Read More White Paper Optimizing Syngeneic Translatability through POC and Target Engagement Studies While syngeneic tumor model use is widespread in preclinical immunotherapy drug development,..
thumb-nhp-exploratory-toxicology Read More Quick Fact NHP Exploratory Toxicology De-risk the path to GLP with early toxicity screening of I/O agents
thumb-qf-inflammation-sle-models Read More Quick Fact SLE Models Advance SLE agent development with robust in vivo models
thumb-qf-inflammation-ms-models Read More Quick Fact MS Models In vivo models to progress your MS inflammation agents to the clinic
thumb-event-nash19 Watch Now Presentation NASH Summit 2019 Presentation - Dr Guodong Zhang Choosing a NASH preclinical model usually means selecting between different elements of the..
thumb-odw-optimize-preclinical-diabetes Watch Now On-Demand Webinar How to Optimize Preclinical Diabetes Studies using Stress Free Methods in.. The key to fighting type 2 diabetes is to develop and utilize novel agents that control multiple..
thumb-nafld-nash-ms-nash Read More Quick Fact NAFLDNASH in the MS-NASH Mouse Advance your NAFLD/NASH therapeutics with a rodent model that more closely mimics human..
thumb-poster-nash-summit19 Read More Poster Comparing Manual and Computerized Preclinical NASH Scoring A Comparison of Computerized Pathology Readings with Manual Readout in the Same Set of NASH..
thumb-cvmd-nafld-nash-dysmetabolic Read More Quick Fact NAFLD/NASH in Dysmetabolic Non-Human Primates Increase your chances of clinical success with spontaneously obese, dysmetabolic, and diabetic..
thumb-aacr19-5111 Read More Poster AACR Poster 5111: New Web Platform for Preclinical Data Analysis HuPharm: An interactive data analysis platform for preclinical studies
thumb-aacr19-4976 Read More Poster AACR Poster 4976: Human CD40 Agonist Antibody Assessment with Human CD40 KI.. Ex Vivo Functional Characterization and In Vivo Efficacy Validation of Human CD40 Agonistic..
thumb-aacr19-4621 Read More Poster AACR Poster 4621: Tumor Homografts for Prostate Cancer Combination Therapy.. Developing Genetically Modified Homograft Models of Mouse Prostate Cancer for Efficacy..
thumb-aacr19-4613 Read More Poster AACR Poster 4613: Evaluating Mathematical Models of Tumor Growth Kinetics Mathematical Modeling of Tumor Growth in Mouse Models
thumb-aacr19-4610 Read More Poster AACR Poster 4610: Predictive Biomarker Discovery in CRC using PDX Models Prognostic Impact of KRAS Driver Mutations and GSTT1 Expression in Colorectal Cancer to FOLFOX..
thumb-aacr19-4609 Read More Poster AACR Poster 4609: Varied Panel of Sarcoma PDX Models Developed Establishment of Sarcoma PDX Models with Various Subtypes for Drug Efficacy Evaluation
thumb-aacr19-4124 Read More Poster AACR Poster 4124: Optimizing a Functional ICB Screening Assay System Expression of Co-Inhibitory Molecules May Impact Immune Checkpoint Therapies
thumb-aacr19-3418 Read More Poster AACR Poster 3418: Authenticating Tumor Models with an NGS-Based SNP Array A NGS-Based SNP Array for the Identification of Human Xenograft Tumors, Mouse Homograft Tumors,..
thumb-aacr19-2375 Read More Poster AACR Poster 2375: Combination I/O Assessment with Double KI Checkpoint Target.. Developing Double Knock-In Models of Human Immune Checkpoint Targets (dKI HuGEMM™) for Efficacy..
thumb-aacr19-2342 Read More Poster AACR Poster 2342: Developing GvHD Models with Human PBMCs and CD34+ Cells Experimental Modeling of Acute- and Chronic-GvHD by Xenotransplanting Human Donor PBMCs or Cord..
thumb-aacr19-1925 Read More Poster AACR Poster 1925: New PDX-Derived Cancer Organoids Developed Establishment and Characterization of 3D Cancer Organoids as Clinically Relevant Ex Vivo Drug..
thumb-aacr19-1503 Read More Poster AACR Poster 1503: Immune Cell Depletion Affects aPD-1 Efficacy Effect of Immune Cell Depletion on Response to PD-1 Treatment in Syngeneic Models
thumb-aacr19-1443 Read More Poster AACR Poster 1443: New Method for Detecting and Monitoring CAR-T Cells in.. Sensitive Detection and Quantification of CAR-T Cells in Treated Patients
thumb-aacr19-1060 Read More Poster AACR Poster 1060: Prostate Cancer PDX for Predictive Preclinical Studies Establishment of a Panel of Prostate Patient-Derived Xenograft (PDX) Models and Evaluation of..
thumb-aacr19-87 Read More Poster AACR Poster 87: Bioluminescent Imaging of Orthotopic Syngeneic Models Recapitulating the Orthotopic Tumor Microenvironment using Bioluminescent Syngeneic Models in..
thumb-qf-syngeneic-models Read More Quick Fact Syngeneic Models Well-characterized syngeneic tumor models for immunotherapy assessment
thumb-qf-muscreen Read More Quick Fact MuScreen Syngeneic and tumor homograft in vivo immunotherapy screening
thumb-poster-muprime-tumor-homografts Read More Quick Fact MuPrime Tumor Homografts Immunocompetent models carrying clinically-relevant oncogenic mutations
thumb-qf-hugemm-hucell-1 Read More Quick Fact HuGEMM and HuCELL Humanized drug target models for immunotherapy evaluation
thumb-qf-genectically-modified-models Read More Quick Fact Genetically Modified Models Reliable, stable, proven technology for custom animal model generation
thumb-odw-pacreatic-cancer-research Watch Now On-Demand Webinar How to Leverage Tumor Models for Pancreatic Cancer Research Pancreatic cancer is a challenging disease to research, in both the preclinical and clinical..
thumb-qf-non-glp-toxicology Read More Quick Fact Non-GLP Toxicology and Safety Pharmacology Studies Gain maximum confidence for regulatory submissions through our range of Non-GLP Toxicology and..
odw-imaging-thumb Watch Now On-Demand Webinar Imaging Orthotopic and Metastatic Preclinical Models for Oncology Drug Discovery Orthotopic tumor models have many advantages over subcutaneous counterparts, including..
thumb-poster-sf19 Read More Poster Prostate Cancer Tumor Homografts for I/O Assessment New preclinical models are needed for prostate cancer drug development, which can be used to..
thumb-odw-exploring-translational-capabilities Watch Now On-Demand Webinar Exploring Translational Capabilities of Preclinical IBD Models The development of a variety of preclinical models has advanced our understanding of underlying..
thumb-aha18 Read More Poster Stress Echocardiography Test to Assess Cardiac Dysfunction in NHPs Developed Intervention studies in human-like species such as NHPs can strengthen target validation and..
thumb-iddst18 Read More Poster IDDST 2018 Presentation Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are becoming..
thumb-poster-presentation Read More Poster Diabetes Summit 2018 Presentation With diabetes prevalence continuing to rise, improved methods are needed for glucose monitoring..
thumb-qf-clinical-chemistry-biomarker Read More Quick Fact Clinical Chemistry and Biomarker Services Make confident decisions from rapid, reliable data in your early preclinical cardiovascular and..
thumb-odw-obesity Watch Now On-Demand Webinar Translational Platforms of Obesity, Dysmetabolism, Diabetes, and Complications A key challenge in preclinical obesity, dysmetabolism, and diabetes studies is the lack of..
thumb-odw-preclinical-prostate Watch Now On-Demand Webinar Preclinical Prostate Cancer Models: Which One is Right For You? Preclinical prostate cancer research is hampered by a lack of predictive models to investigate..
thumb-event-boston-skyline Event AACR-NCI-EORTC International Conference on Molecular Targets and Cancer..

October 26 - 30, 2019 | Booth #410 | Boston
Preview Posters
www.aacr.org
nation-harbor-md Event SITC 2019

November 6 - 10, 2019 | National Harbor, MD
www.sitcancer.org
thumb-event-paris-france Event Symposium: Taking Immunotherapies to the Next Level

November 7, 2019 | Paris, France
Register Now
london-uk-thumb Event 2019 NC3Rs Meeting

November 8, 2019 | London, UK
Preview Poster
www.nc3rs.org.uk
thumb-webinar-hub-tumor-organoids Event Webinar: Applications of HUB Tumor Organoids in Oncology Drug Discovery

November 13, 2019
Register Now
thumb-event-uk-london Event 7th Annual PREDiCT: Tumor Models London Summit

December 3 - 5, 2019 | London, UK
www.tumour-models.com
thumb-poster-nc3r Read More Poster Poster: Using PDX for In Vivo CAR-T Cell Therapy Assessment Efficient growth suppression of pancreatic cancer PDX by fully human anti-mesothelin CAR-T cells
thumb-ena18-poster329 Read More Poster Poster 329: Orthotopic Syngeneics: More Clinically Relevant I/O Models Recapitulating the orthotopic tumour microenvironment using bioluminescent syngeneic models in..
thumb-ena18-poster327 Read More Poster Poster 327: Prostate Cancer Patient-Derived Xenograft Treatment Data Evaluation of anti-androgen therapy in a panel of prostate patient-derived xenograft models
thumb-ena18-poster313 Read More Poster Poster 313: Orthotopic Homograft Tumours Display Distinct TIL Patterns Orthotopic homograft tumours (syngeneic) display distinct tumour infiltrate immune cell patterns..
thumb-ena18-poster312 Read More Poster Poster 312: Comparing Kidney Cancer Genomics Across Populations Genomic characterisation of Chinese clear cell renal cell carcinoma revealed novel prognostic..
thumb-ena18-poster305 Read More Poster Poster 305: Comparing Categorical Response Methods for Tumour Model Studies Evaluation of categorical response methods in predicting drug responses in transplanted tumour..
thumb-ena18-poster250 Read More Poster Poster 250: Tumour Homografts for Prostate Cancer I/O Development Establishment of mouse prostate homograft tumour models for efficacy evaluation of combinatory..
thumb-ena18-poster241 Read More Poster Poster 241: Characterising Syngeneics to Guide Model Selection Utilising murine syngeneic model systems in I/O drug discovery: broad applications and guidance..
thumb-ena18-poster240 Read More Poster Poster 240: Evaluate Bispecific Antibodies with PBMC-Humanised Models Establishment and application of a panel of PBMC-humanised mouse tumour models in..
thumb-ena18-poster226 Read More Poster Poster 226: Immune Checkpoint Double Knock-In Models for I/O Testing Generation of human immune checkpoint double knock-in mice (dKI HuGEMM™) for preclinical..
thumb-publication-car-t-cells Read More Publication Assessing CAR-T Cell Therapy for Pancreatic Cancer with PDX Models Despite an improvement in our knowledge of pancreatic cancer biology, standard of care treatment..
thumb-jove Read More Publication Profiling the TME of PDAC Tumor Homografts Pancreatic ductal adenocarcinoma (PDAC) does not respond to a range of cancer therapies (e.g...
thumb-mct-publication Read More Publication Using MCT to Identify EGFR Predictive Biomarker in ESCC Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal tumors...
odw-thumb-xenografts Watch Now On-Demand Webinar Patient-Derived Xenografts as Models for Metastatic Breast Cancer and.. Breast cancer is a highly heterogeneous, complex disease affecting millions of women worldwide...
thumb-poster1021 Read More Poster Poster 1021: New Preclinical Mouse Model of Diabetic Nephropathy Next Generation of Spontaneous Diabetic Model of MS-NASH (FATZO) Mice with Intact Leptin..
thumb-poster535 Read More Poster Poster 535: New Preclinical Model for Diabetic Cardiomyopathy Next Generation of Spontaneous Diabetic Model of ZDSD Rats with Intact Leptin Signaling Develop..
thumb-p3-9 Read More Poster Poster 3.9: Novel Uses for PDX Models in Preclinical Drug Development Cancers are diverse genetic and immunological abnormalities, which results in specific..
thumb-wp-new-advancements Read More White Paper New Advancements in Preclinical Prostate Cancer PDX Models Enhance Prostate Cancer Drug Development with More Translational Preclinical Models including..
thumb-tumor-models-17 Watch Now Presentation Tumour Models London 17 Presentation - Dr Rajendra Kumari There is an increasing demand for clinically relevant and predictive models in preclinical..
thumb-adme-dmpk Read More Quick Fact ADME, DMPK, and Bioanalysis Integrated in vitro and in vivo pharmacological and bioanalytical platform
thumb-wp-immunocompetent-murine-models Read More White Paper Immunocompetent Murine Models: A Guide to Understanding their Place in.. The Challenge: How to Explore and Evaluate Novel Immunotherapies and Combination Regimens before..
thumb-pb10520 Read More Poster Assess Targeted I/O Agents with PBMC-Humanized Models There is an increasing need for fast, reliable, and cost-effective immunocompetent models for..
poster-3d-ex-vivo Read More Poster Discover Robust 3D Ex Vivo Compound Screening Ex vivo cancer pharmacology has shown advantages over in vitro and in vivo approaches in..
thumb-996 Read More Poster Novel PDAC Murine Homografts for I/O Drug Development Preclinical, immunocompetent models are needed for immunotherapy drug development in pancreatic..
human-cd3-thumb Read More Poster Bispecific Antibody Evaluation via CD3E Transgenic Model Preclinical development and evaluation of T cell-redirecting antibodies is often blocked by a..
thumb-421-p Read More Poster ZDSD Rat Preclinical Model for Cardiomyopathy Drug Discovery Cardiomyopathy is the leading cause of morbidity and mortality among diabetes and obesity..
thumb-1728-p Read More Poster Patient Relevant Immune Cell Response in MS-NASH (FATZO) T2D Model Type 2 diabetes and obesity are strongly associated with a peripheral immune response. Disease..
bioluminescent-syngeniec-models-thumb Read More Poster Bioluminescent Orthotopic Syngeneics for I/O Assessment There are limited treatment options available for hepatocellular carcinoma (HCC), which is an..
poster-60-thumb Read More Poster In Vitro Assay Platform to Test Anti-CD47 Agents CD47 is a transmembrane protein belonging to the immunoglobulin family. It acts as a “don’t eat..
poster-230-thumb-1 Read More Poster Improved CD3E Transgenic Mouse Model for I/O Agent Testing Preclinical models are required to test T cell-redirecting bispecific antibodies targeting CD3E...
fatzo-mouse-poster-thumb-1 Read More Poster NAFLD/NASH Mouse Model with Metabolic Dysregulation Metabolic disturbances such as insulin resistance, obesity, and dyslipidemia are prominent risk..
1016-video-thumb Read More Poster Investigating the TME through PDX RNAseq Analysis Cancers are collections of diverse diseases, of both genetic and immunological abnormalities...
thumb-1051-1 Read More Poster WES and RNAseq Comparison of PDX Mutations Patient-derived xenografts (PDX) are widely used, highly predictive, preclinical oncology..
thumb-jds17-poster2 Read More Poster Poster a90037: DGAT-1 Inhibition in Obese Mice vs NHPs The microsomal enzyme diacylglycerol O-acyltransferase 1 (DGAT-1) plays a key role in the..
thumb-jds17-poster1 Read More Poster Poster a90026: Banana Tolerance Test – A Stress Free Alternative to oGTT Spontaneously diabetic NHPs are a highly translatable preclinical model for the evaluation of..
1144-video-thumb Read More Poster KPC Homograft Models for PDAC Combination I/O Studies Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult to treat cancer types,..
1264-video-thumb Read More Poster Microbiota Enrichment Associated with PD-1 Response Studies have shown that the gut microbiome may influence antitumor immune response via innate..
thumb-2167 Read More Poster DLBCL PDX Models with Diverse Genotypes for BTKi Testing Bruton's tyrosine kinase (BTK) activation is a major oncogenic driver for various B cell-derived..
3809-video-thumb Read More Poster IDO1 Inhibition Assay Measuring Kyn Levels Developed IDO1 is a major mechanism of immunosuppression in tumors, with expression of IDO1 by tumor cells..
3861-video-thumb Read More Poster New Ex Vivo PDX Compound Screening Platform Patient-derived xenograft (PDX) models are in high demand in preclinical drug development due to..
4059-video-thumb Read More Poster TIL-Treg Subtype Shift Induced by Vaccination Tumor infiltrating lymphocytes, including regulatory T cells (Treg), are believed to play a..
4556-video-thumb Read More Poster Disrupting the CD47-SIRPa Anti-Phagocytic Axis in I/O Macrophages provide an important surveillance system, which can be escaped by human tumors..
5033-video-thumb Read More Poster Recapitulating the TME in Ex Vivo 3D Tumor Growth Assay The assessment of novel tumor microenvironment (TME) targeting therapies is currently hindered..
5116-video-thumb Read More Poster Using Genetic Features to ID and QC Murine I/O Models Mouse tumor homografts (derived from syngeneics, GEMM, etc.) engrafted in their corresponding..
5669-video-thumb Read More Poster CD3E Transgenic Mouse Model for Bispecific Antibody Testing T cell-redirecting therapy is taking a prominent role in immuno-oncology. Recent research has..
5677-video-thumb Read More Poster PBMC-Humanized Models for Targeted Cancer Immunotherapy Monoclonal antibodies and checkpoint inhibitors have achieved remarkable clinical success in..
establishment-of-kras-thumb Read More Poster KPC Homograft Models for PDAC Combination Immunotherapy Development Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and remains one of the..
preclinical-efficacy-evaluation-thumb-1 Read More Poster Humanized OX40 Mouse Models for Preclinical I/O Studies OX40 is a co-stimulatory receptor of the TNF receptor superfamily, and is at the forefront of..
transcriptomic-analysis-thumb Read More Poster Using PDX as Surrogate Models for TME Investigation Cancers are being increasingly recognized as collections of diverse immune diseases, on top of..
mixeno-thumb-1 Read More Poster PBMC-Humanized Models for In Vivo I/O Studies The recent rise in cancer immunotherapy research and drug approvals is providing promising..
CrownBio-Tumor-Models-London-2017-thumb Read More Poster Orthotopic, Bioluminescent Syngeneic HCC Models for Immunotherapy Assessment There are currently limited treatment options for hepatocellular carcinoma (HCC), which is a..
NGCS-2017-poster-ovarian-cancer-bioluminescent-imaging-thumb Read More Poster Orthotopic, Bioluminescent Ovarian Cancer Xenograft Models Developed Due to late diagnoses and common treatment failure, ovarian cancer has a high lethality, and is..
WPC-EU-2017-thumb Read More Poster Evaluate Human Origin OX40 Therapeutics In Vivo OX40, a member of the TNF superfamily, is now at the forefront of the field known as “T cell..
SITC-2017-poster-thumb Read More Poster Evaluate Human-Specific Immunotherapies In Vivo Immunotherapies have demonstrated considerable success in oncology research, treating a variety..
A27-syngeneic-popn-study-thumb Read More Poster Immunosuppressive Phenotype and Poor I/O Agent Response Correlation While checkpoint inhibitors are proving highly successful in oncology, a large proportion of..
A63-KPC-Shanghai-AACR-thumb Read More Poster KPC Homograft Models for PDAC I/O Efficacy Studies Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and remains one of the..
A64-MuScreen-Shanghai-AACR-thumb Read More Poster In Vivo Syngeneic Screening Platform for Immunotherapeutics Syngeneic tumor models are the current workhorse in immunotherapy evaluation. They have a long..
A65-Microbiota-thumb Read More Poster Anti-PD-1 Treatment Induces Gut Microbiota Changes Commensal microbiota plays an important role in both physiological and pathological processes..
B20-Survivalanalysis-Shanghai-AACR-thumb Read More Poster Frailty Models Better Assess Drug Efficacy in MCTs Mouse clinical trials (MCTs) use a cohort of patient-derived xenograft (PDX) models to evaluate..
B21-combination-effects-AACR-Shanghai-thumb Read More Poster Evaluate and Quantify Two-Drug Combination Effects In Vitro Combination therapy provides the opportunity for increased efficacy and reduced toxicity and..
B59-Lymphoma-Shanghai-thumb Read More Poster Clinically Relevant DLBCL PDX Models for BTK Inhibitor Testing The activation of Bruton's tyrosine kinase (BTK) is considered as a major oncogenic driver for..
B73-OX40-Shanghai-AACR-thumb Read More Poster Human OX40 Knock-In Model for I/O Agent In Vivo Testing OX40 is a co-stimulatory molecule and a member of the TNF superfamily, and is at the forefront..
B74-MiXeno-AACR-Shanghai-thumb Read More Poster Characterization of PBMC Humanized Models for I/O Studies The recent growth in cancer immunotherapy has provided both promising treatment options for..
B75-phenotyping-AACR-Shanghai-thumb Read More Poster Comprehensive Profiling of a Variety of I/O Models Immunotherapies such as checkpoint inhibitors have achieved great success in treating cancer..
video-humanized-models Watch Now Presentation Tumor Models San Francisco 2018 Presentation - Dr H Toni Jun While immunotherapy continues to dominate cancer research, a number of questions and challenges..
biocom-screen Watch Now Presentation BioCom Humanized Oncology Model Seminar 2018 - Dr H Toni Jun Immunotherapy has proven to be a game changer in treating many cancer types e.g. metastatic..
B78-CD47-AACR-Shanghai-thumb Read More Poster Disrupting the CD47-SIRPa Anti-Phagocytic Axis: A Novel I/O Approach Most human tumors express CD47 to escape macrophage surveillance. Therefore reinstating..
B80-combination-Shanghai-AACR-thumb Read More Poster Combination Screening of I/O and Targeted Agents In Vitro To advance preclinical immuno-oncology drug discovery, CrownBio has developed a syngeneic model..
eortc-slide Watch Now Presentation EORTC 17 Short Talk - Dr Henry Q. Li It is being increasingly recognized that cancers are not just genetic diseases, but are also..
A003-AML-thumb2 Read More Poster Immunocompetent AML Model for Preclinical Efficacy Testing Acute myeloid leukemia (AML) treatment options stagnated for many years, until the approval of..
A009-Prostate-PDX Read More Poster Characterization of Prostate Cancer PDX Models Prostate cancer is the second most common cancer worldwide for males, and the fourth most common..
A010-thumb Read More Poster Orthotopic, Bioluminescent Syngeneic HCC Models Developed Hepatocellular carcinoma (HCC) is an aggressive cancer type with limited therapeutic treatment..
A013-PDX-annotation Read More Poster Discover the World’s Largest, Well-Characterized PDX Collection Patient-derived xenograft (PDX) models are recognized as the most predictive preclinical models,..
A026-Henry-Cetxuimab-response-carcinoma-FINAL Read More Poster Cetuximab Response vs EGFR Expression Analysis Currently, the link between cetuximab treatment response and EGFR expression level is unclear...
tim3-thumb Read More Poster Evaluate Human-Specific TIM-3 Immunotherapeutics In Vivo Research is currently ongoing on how to improve the low overall response rate to checkpoint..
A207-OX40-thumb Read More Poster Evaluate the Efficacy of Human OX40 Therapeutics and Combination Regimens In.. OX40 is a member of the TNF superfamily, and is now at the forefront of the field known as “T..
A213-3D-TGA-thumb Read More Poster 3D-Tumor Growth Assay Data Correlate with In Vivo Efficacy Study Results Current preclinical in vitro and in vivo models lack human stromal cells, and are therefore not..
B002-CD47-thumb-1 Read More Poster Developing Novel Immuno-Oncology Assays for Anti-CD47 Research Expressing CD47 is a technique used by most human tumors to escape macrophage surveillance...
B008-Gut-Microbiota Read More Poster Gut Microbiota Abundance Regulated by Anti-PD-1 Treatment New research has revealed that gut microbiota has the potential to act as biomarkers that could..
B014-muscreen Read More Poster Cost Effective, In Vivo Syngeneic I/O Agent Screening Panel In vitro cell-based screens frequently used in oncology to quickly identify responsive cells,..
B078-MiXeno-Poster Read More Poster PBMC Humanized In Vivo Models for Evaluation of Human-Specific I/O Agents There are multiple published strategies for creating humanized mouse models, including..
B209-stroma Read More Poster PDX as Surrogate Models for TME Investigation It is being increasingly recognized that cancers are collections of diverse immune, as well as..
AACR-TII-2017-A05-Microbiota-Poster-THUMB Read More Poster Anti-PD-1 Treatment Induces Gut Microbiota Profile Changes Commensal microbiota plays an important role in both physiological and pathological processes..
AACR-TII-2017-A49-Phagocytosis-Poster Read More Poster A Novel Immunotherapy Approach Against Cancer Most human tumors express CD47 to escape macrophage surveillance. Therefore targeting CD47 to..
AACR-TII-2017-B28-MiXeno-Poster-THUMB Read More Poster MiXeno™ – Simple, Fast, and Cost-Effective Humanized Models Preclinical humanized mouse models are required to assess human-specific therapeutics. Different..
lipid-liver-fat Read More Poster Spontaneously Diabetic NHPs are Valuable Preclinical Models for Liver Steatosis Diabetes is frequently associated with abdominal fat accumulation and lipid disorders, which..
cimt-poster-thumb Read More Poster Humanized CD137 Models for Preclinical Drug Development PD-1/PD-L1 checkpoint inhibitors have achieved huge clinical success (and drug approval) across..
cd137-thumb-1 Read More Poster Evaluate Human Specific CD137 Antibodies Despite the huge clinical success of PD-1/PD-L1 checkpoint inhibitors in multiple tumor types,..
ADA-2017-1820P Read More Poster Naturally Diabetic NHP Immune Cell Changes Correspond to Human Diabetics Changes in immune cell distribution have been found to correlate with disease progression in..
thumb-1881 Read More Poster Continuous Glucose Telemetry Monitoring: A Useful Tool for Diabetes Research Disruption of human biological rhythms, e.g. by shift work, can increase the risk of developing..
thumb396 Read More Poster WES - A Better Approach to PDX CNV Detection Prediction of DNA copy number variation (CNV) is a critical component of genomic profiling, as..
thumb-1647 Read More Poster MiXeno™ - a Rapid and Simple Strategy for Model Humanization Despite the unprecedented success of immune checkpoint antibodies for a variety of cancer types,..
thumb-1658 Read More Poster CD137 Target Humanized Model Established CD137 belongs to the TNF receptor super family, and its activation is essential to the function..
thumb-1665 Read More Poster MuScreen™ – the First In Vivo IO Syngeneic Screening Platform Immunotherapeutics can be difficult to evaluate preclinically - in vitro cell-based screens..
thumb-1829 Read More Poster Exploring Immunotherapies Through BLI Subcutaneous syngeneic models are widely used to evaluate the impact of immunotherapy on tumor..
thumb-2008 Read More Poster Microbiota Dynamically Facilitate Anti-PD-L1 Efficacy Cancer immunotherapies such as antibodies targeting programmed death-ligand 1 (PD-L1), a..
thumb-2696 Read More Poster Anti-PD-1 Induced Microbiota Changes Increasing evidence has shown that gut microbiota play an important role in shaping systemic..
thumb-2807 Read More Poster MuPrime™ – A Novel Mouse Model for PARP Inhibitor Evaluation PARP inhibitors (PARPi) have seen a resurgence since their approval for BRCA mutated ovarian..
thumb-2811 Read More Poster Evaluate TILs and TAMs in Syngeneic Models CrownBio has developed a syngeneic model screening platform to facilitate the preclinical..
thumb-2824 Read More Poster Discover New PDX Models for Prostate Cancer Prostate cancer is the second most common cancer worldwide for males, and the fourth most common..
thumb-4203 Read More Poster A Novel PDX Model to Evaluate FL-HCC Therapies Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare and distinct primary hepatic..
thumb-4534 Read More Poster How to Design and Analyse your MCT Patient-derived xenografts (PDX) are a well-accepted experimental cancer model mimicking..
thumb-4707 Read More Poster Humanized PDX Models for Anti-PD-1 Evaluation Human immune-reconstituted mice, generated by transplanting human CD34® hematopoietic stem cells..
thumb-korean-diabetes-assoc16 Read More Poster Poster: Non-Human Primate Models for Dyslipidemia and Dysglycemia Research Obesity and diabetes are among the most serious public health issues of this century. They..
thumb-dot-fatzo-nafld Read More Poster Poster: The MS-NASH (FATZO) Mouse Model of Type 2 Diabetes Develops.. Non-alcoholic fatty liver disease (NAFLD) develops at a higher rate in obese, Type 2 diabetic..
thumb-dot-sonography Read More Poster Poster: Hepatic Lipidosis and Fibrosis in Obese, Dysmetabolic, and Diabetic.. Liver biopsy is the gold standard for clinical diagnosis of nonalcoholic fatty liver disease..
thumb-5597-2 Read More Poster In Vitro Combination Screening of IO and Targeted Agents CrownBio has developed a syngeneic model screening platform to facilitate the preclinical..
poster-atmc-2016-muscreen-thumb Read More Poster A Panel of Well-Characterized Syngeneic Models for MuScreen™ In Vivo Screening  In vitro screening is frequently used in oncology to quickly identify responsive cells, models,..
poster-ada-2016-79lb-thumb Read More Poster The Use of Dexcom G4 Continuous Glucose Monitoring in Diabetes NHP Research The Continuous Glucose Monitoring (CGM) system is approved by the FDA for 24-hr real time..
poster-ada-2016-308lb-thumb Read More Poster Characterization of MS-NASH (FATZO) Mice for Diabetes and Obesity Research Obesity is a growing threat resulting in co-morbidities of diabetes and cardiovascular disease.
poster-ada-2016-911p-thumb Read More Poster Advantages of Glucose Monitoring with an Implantable Telemetry Device in Freely.. Insulin-resistant diabetes (Type 2 diabetes mellitus, T2DM) is the most common form of diabetes..
poster-ada-2016-1822-thumb Read More Poster Hepatic Lipidosis and Fibrosis in Obese, Dysmetabolic, and Diabetic Non-Human.. Liver biopsy is the gold standard for clinical diagnosis of nonalcoholic fatty liver disease..
poster-aacr-2016-747-thumb Read More Poster Autocrine c-Met/HGF HCC PDX: Evaluation of a Biologic Targeting c-Met The mesenchymal-epithelial transition factor (c-Met) represents an important target for cancer..
poster-aacr-2016-3219-thumb Read More Poster Immunization is Critical to PD-1/PD- L1 Response in a Mouse Breast Cancer.. Immuno-oncology is an area under intense investigation due to the successful development of..
poster-aacr-2016-3994-thumb Read More Poster Immunology Syngeneic Models Demonstrate Additive Effects of Combination.. Recent progress in the field of cancer immunotherapy (IT) has made it possible to translate..
poster-aacr-2016-4043-thumb Read More Poster A Novel Mouse Skin Squamous Cell Carcinoma Allograft Model for In Vivo.. The recent clinical success of novel therapeutics blocking the immune checkpoints cytotoxic..
poster-aacr-2016-5176-thumb Read More Poster Orthotopic Syngeneic Tumor Models for Preclinical Evaluation of Cancer.. The recent clinical success of immunotherapy in indications such as melanoma and lung cancer has..
poster-aacr-2016-5177-thumb Read More Poster RNAseq and FACS Profiling of Syngeneic Mouse Models Treated with Immune..  Syngeneic tumor models have long been used in cancer research. Recently, the clinical success..
poster-aacr-2016-5179-thumb Read More Poster Development of a Humanized Mouse Model for Direct Evaluation of Anti-Human.. Therapies that perturb binding of the programmed death-ligand 1 (PD-L1) to its receptor,..
poster-aacr-2016-5186-thumb Read More Poster Using HuTrial™ to Aid in Predicting a Patient Population of Responders One of the biggest challenges in drug discovery is directing drug treatment to the correct..
poster-aacr-2016-6444-thumb Read More Poster MiXeno™ Humanized Mouse Model as an Efficient Tool to Evaluate In Vivo Activity.. Pancreatic ductal adenocarcinoma (PDA) remains one of the most aggressive tumors in humans. A..
poster-endo-2016-sun-720-thumb Read More Poster Blood Glucose Fluctuations during Daily Activities and Stress Procedures in.. Insulin-resistant diabetes (Type 2 diabetes mellitus, T2DM) is the most common form of diabetes..
thumb-fatzo-mouse-gtc-2015 Read More Poster The FATZO Mouse – A Translatable Model for GLP-1 Agonist Screening Glucagon-like Peptide-1 (GLP-1) receptor agonists, e.g. semaglutide, improve glucose homeostasis..
poster-aacr-2015-765-thumb Read More Poster Overcoming Acquired Resistance in NSCLC with Targeted Beam Irradiation in.. Lung cancer is the largest cancer killer with poor 5-year survival rate. Non-small cell lung..
poster-aacr-2015-769-thumb Read More Poster In Vivo Response and Molecular Characterization of a Caucasian NSCLC Squamous.. The fbroblast growth factor receptor (FGFR) family are reported to be involved in key cellular..
poster-aacr-2015-1038-thumb Read More Poster Cell-based Screening Identifies Gene Expression Signature Correlated with.. The PI3K-Akt-mTOR signaling cascade is one of the most well known pro-proliferation and..
poster-aacr-2015-1472-thumb Read More Poster Building a Comprehensive and Fully Annotated Patient Tumor Derived Xenograft.. Patient derived xenografts (PDXs) mirror patients’ pathology and genetic profles, and are..
poster-aacr-2015-1802-thumb Read More Poster Application of Small Animal Image-Guided Irradiation to Preclinical In Vivo.. Patient derived xenograft (PDX) models sustain tumour heterogeneity and genetic integrity of the..
poster-aacr-2015-1926-thumb Read More Poster Patient-Derived Xenograft Seem to Have Closer Global Expression Profile to that.. Patient derived xenografts (PDXs) without in vitro manipulation are believed to mirror original..
poster-aacr-2015-2281-thumb Read More Poster Building Mouse Tumor Derived Allografts for Immuno-Oncology Research Limited types/numbers of available syngenic cells also restrict its application. Genetically..
poster-aacr-2015-3221-thumb Read More Poster A Patient-Derived Xenograft (PDX) Platform for Development of Next Generation.. Despite best efforts in the treatment of gastrointestinal stromal tumors (GIST), patients..
poster-aacr-2015-3224-thumb Read More Poster Living Tumor Bank and Patient-Derived Xenograft Models: A Powerful.. Patient-derived xenograft (PDX) models have been established from the world’s largest living..
poster-aacr-2015-3226-thumb Read More Poster Patient-Derived Xenograft (PDX) Models for Triple Negative Breast Cancer.. In the United States, TNBC comprises 15-20% of breast cancers and are characterized by the lack..
poster-aacr-2015-3235-thumb Read More Poster Validation of Anti-Human PD-1 and PD-L1 Antibodies in MiXeno™ Mouse Models As evidenced by strong clinical data from antibodies targeting cytotoxic T-lymphocyte antigen 4..
poster-aacr-2015-3581-thumb Read More Poster Rapid Conversion to Resistance of a Colon PDX with RET Fusion by Ponatinib.. RET encodes a receptor tyrosine kinase (RTK) involved in cellular mechanisms of proliferation,..
poster-aacr-2015-4209-thumb Read More Poster Development of Patient-Derived Xenograft Models for Small Cell Lung Cancer as a.. Small cell lung cancer comprises 15-20% of all lung cancer cases, and is more invasive and has a..
poster-aacr-nci-eortc-2015-247-thumb Read More Poster Drug Resistant Murine Tumor Models Facilitate the Development of Next.. Despite the development of promising new anticancer drugs, all cancer therapeutics, including..
poster-aacr-nci-eortc-2015-382-thumb Read More Poster Response to Checkpoint Inhibition by GEMM Breast Cancer Allograft Response to immunotherapy (I/O, e.g. to checkpoint inhibitors) in cancer patients, differs..
poster-aacr-nci-eortc-2015-394-thumb Read More Poster Induction of Resistances to Crizotinib in NSCLC Patient-Derived Xenograft.. Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, and its mutation,..
poster-aacr-nci-eortc-2015-396-thumb Read More Poster Molecular Pathology of Patient Tumors, Patient-Derived Xenografts and Cancer.. Cancers are heterogeneous diseases with diverse pathogenesis. Clinical diagnosis is primarily..
poster-aacr-nci-eortc-2015-399-thumb Read More Poster A HuGEMM h/mPD1 Mouse Model for Testing Anti-Human PD-1 Therapeutics The recent approval of two monoclonal antibodies targeting the immune checkpoint programmed cell..
poster-ada-2015-dynamic-changes-of-betatrophin-thumb Read More Poster Dynamic Changes of Betatrophin, Insulin, and Glucose during STZ Induction of.. Betatrophin, also called angiopoietin-like protein 8/lipasin, characterized from the liver can..
poster-ada-2015-long-term-continuous-glucose-thumb Read More Poster Long-term Continuous Glucose Monitoring in Conscious Stress-free Non-Human.. Diabetes becomes a global epidemic issue. Aging nonhuman primates (NHPs) develop insulin..
poster-ada-2015-effects-of-anesthesia-thumb Read More Poster Effects of Anesthesia on Metabolic Responses to Mixed Meal Tolerance Test in.. Mixed meal tolerance test (MMTT) is commonly used in diabetic research in experimental animal..
poster-ada-2015-left-ventricular-diastolic-thumb Read More Poster Left Ventricular Diastolic Dysfunction in Diabetic and Dysmetabolic Non-human.. Diabetes is one of the major risk factors for heart failure with reduced ejection fraction (EF),..
poster-ash-2015-2759-thumb Read More Poster Activating Mutations in MYD88 and CD79B Are Predictive of Response to Ibrutinib.. DLBCL is the most common form of nonHodgkin’s lymphoma (NHL) consisting in 2 subtypes: the..
poster-cri-cimt-eati-aacr-2015-b115-thumb Read More Poster Application of Image-Guided Irradiation to a Preclinical Bioluminescent.. Radiotherapy is a primary, adjuvant or neoadjuvant treatment for a number of different cancers..
poster-cri-cimt-eati-aacr-2015-b117-thumb Read More Poster Profiling of Syngeneic Models by Check Point Inhibitors, RNAseq, and FACS.. Syngeneic tumor models have long been used in cancer research. The recent clinical success of..
poster-ecco-2015-228-thumb Read More Poster Preclinical Mouse Trials (MCT) to Guide the Human Studies Patient-derived xenograft (PDX) tumor models are widely used for assessing cancer treatments,..
poster-ecco-2015-201-thumb Read More Poster Profiling of Syngeneic Models by Anti-PD-1, PD-L1 and CTLA-4 Immunotherapeutics..  Syngeneic tumor models have long been used in cancer research. The recent clinical success of..
poster-nhcr-2015-87-thumb Read More Poster A Novel RET TKI Inhibits Growth of Patient-Derived Xenografts with RET Fusion.. Activation of RET, a RTK proto-oncogene, is associated with the development of several human..
poster-nhcr-2015-36-thumb Read More Poster Drug Resistant Murine Tumor Models Facilitate Development of Next Generation.. Despite the development of promising new anticancer drugs, all cancer therapeutics, including..
poster-nhcr-2015-103-thumb Read More Poster Establishment of a Humanized PD-1 Mouse Model for In Vivo Pharmacological.. The recent approval of two immunotherapeutic agents targeting the immune checkpoint programmed..
poster-nhcr-2015-95-thumb Read More Poster Establishment of a Mouse Breast Cancer Allograft Model for In Vivo.. The recent clinical success of novel therapeutics blocking the immune checkpoints cytotoxic..
poster-nhcr-2015-90-thumb Read More Poster High Efficacy of a Novel and Specific c-MET TKI in a Cohort of PDXs from.. Turning on c-Met signaling, through gene amplification, activating mutations or interaction with..
poster-2015-121-thumb Read More Poster Immunological Characterization: Allograft of Primary Murine Breast Cancer.. Thanks to the recent success in clinical trials, immunotherapy has become the main focus of..
thumb-aacr-1206 Read More Poster Parameters Influencing Design of Mouse Clinical Trial (HuTrial™) Patient-derived xenograft (PDX) is increasingly used to evaluate oncology drug. The fast..
thumb-aacr-2054-1 Read More Poster Patient Relevant Preclinical In Vivo Models Using Image-Guided Small Animal.. We have recently successfully engrafted leukemic cells from bone marrow of 4 AML patients into..
thumb-aacr-2562 Read More Poster Evaluate In Vivo Efficacy of Antitumor Immunotherapeutics Using MiXeno™ Mouse.. The past few years have witnessed a renaissance in the field of cancer immunotherapy, relating..
thumb-aacr-3123 Read More Poster Modeling Anti-Leukemic Therapy by Patient-Derived AML Xenografts with Distinct.. We have recently successfully engrafted leukemic cells, isolated from bone marrows of 3 AML..
thumb-aacr-3124-3 Read More Poster Xenograft Models for Development of New Drugs Targeting Fibroblast Growth.. The fibroblast growth factor receptors (FGFR) are tyrosine kinases that are present in many..
thumb-aacr-3136 Read More Poster X-MAN™ Isogenic DualXeno™ Models with KRAS Mutation Predicts the Effect of.. We have previously reported using cell lines generated with Horizon Discovery’s rAAV-based..
thumb-aacr-3440 Read More Poster Cell-based Screening Identifies Gene Expression Signature Correlated with.. The Ras-Raf-MEK-ERK signaling cascade is one of the most well known pro-proliferation and..
thumb-aacr-4875 Read More Poster In Vivo and In Vitro Generation and Characterisation of EGFR-TKI Resistance in.. Most non-small cell lung cancer (NSCLC) patients that have activating mutations in the EGFR gene..
thumb-syngeneic-models Read More Poster Syngeneic Models for Developing Cancer Therapeutics Targeting Immune System Syngeneic tumor models have long been used in cancer research, from mechanistic study to..
thumb-patient-derived-nsclc-xenograft Read More Poster Treatment of Patient-Derived NSCLC Xenograft Preclinical Models Using.. Radiotherapy is a primary, adjuvant or neoadjuvant treatment for a number of different cancers..
thumb-poster-nsclc Read More Poster Development of a Gene Signature for Stratifying Cisplatin Treatment of NSCLC.. Cancer is not a single disease, reflecting that no single treatment can be broadly effective to..
thumb-poster-xenograft Read More Poster Induction of Resistance to Targeted Therapies in Patient-Derived Xenograft.. Oncogene activating mutations have been found to be oncogenic drivers in many different cancers,..
thumb-poster-aml Read More Poster Patient-Derived AML Xenografts for Drug Evaluation We have recently successfully engrafted leukemic cells from bone marrow of 4 AML patients into..
thumb-pub-anesthesia Read More Publication Anesthesia Effects on NHP ivGTT and MMTT Intravenous glucose (ivGTT) and mixed meal (MMTT) tolerance tests are commonly used to evaluate..
thumb-pub-omega-3-cvd Read More Publication Positive Impact of Omega-3 on CVD Risk Factors in Dyslipidemic NHPs High serum cholesterol levels, particularly LDL cholesterol, are a significant cardiovascular..
thumb-pub-omega-3-index Read More Publication Effects of Increasing Omega-3 Index on Erythrocyte Membrane Fatty Acid Levels The omega-3 index is a commonly used method to reflect the intake of the long-chain omega-3..
thumb-hepati-steatosis Read More Publication Noninvasive Echography of NASH in Obese, Dysmetabolic, and Diabetic NHP Nonalcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH) is one of the most common causes..
thumb-zdsd-rat-diabetic-nephropathy Read More Publication ZDSD Rat – A Novel Preclinical Model of Diabetic Nephropathy Diabetic nephropathy is the leading cause of end-stage renal disease, and is estimated to occur..
thumb-sci-reports Read More Publication Comparing CGM Systems Preclinically for Diabetes Research Continuous glucose monitoring (CGM) is an alternative to standard blood glucose measurement..
pub-thumb-characterization-zdsd-rat Read More Publication ZDSD Rat Characterization Metabolic diseases are broadly defined as pathological conditions caused by dysregulation of..
thumb-pub-zdsd-rat-improved-model Read More Publication ZDSD Rat – Improved Model for Diabetic Wound Healing Animal models of diabetic delayed wound healing are essential to the development of strategies..
thumb-fatzo-mouse-improved-model Read More Publication FATZO Mouse - Improved Model for Preclinical Screening of Agents to Stop or.. The FATZO/Pco mouse is an inbred strain exhibiting obesity in the presumed presence of an intact..
thumb-pub-fatzo-mouse-optimize Read More Publication FATZO Mouse - Optimize Studies of Prevention, Stabilization, or Treatment of.. Quantitation of β-cell function is critical to better understand the dynamic interactions of..
thumb-pub-continuous-telemetry Read More Publication Continuous Telemetry for More Physiologically Relevant NHP Glucose Monitoring Continuous blood glucose monitoring in diabetic patient research is extremely challenging,..
thumb-pub-ivgtt-provides-valuable Read More Publication IVGTT Provides Valuable Information on NHP Metabolic State The intravenous glucose tolerance test (IVGTT) plays a key role in the characterization of..
thumb.png-pub-insulin-resistance Read More Publication Insulin Resistance Similarities in Diabetic NHPs and Humans Insulin resistance and diabetes can develop spontaneously with obesity and aging in rhesus..
thumb-pub-nhp-liver-expresses-1 Read More Publication NHP Liver Expresses Abundant Betatrophin mRNA Betatrophin reportedly plays a major role on stimulating proliferation of islet cells and..
thumb-pub-naturally-obese-nhp Read More Publication Naturally Obese NHPs – Highly Translatable Animal Models for Human Dysmetabolism Many animal models have been used to research and understand the mechanisms of obesity, and to..
thumb-pub-dysmetabolic-hhp-highly Read More Publication Dysmetabolic NHPs are Highly Translatable for Cardiometabolic Disorders Diabetes is one of the major risk factors for cardiomyopathy and heart failure with reduced..
thumb-pub-first-detailed-charcter-nhps Read More Publication First Detailed Characterization of Diabetic Nephropathy in NHPs It is well-recognized that non-human primate (NHP) models of diabetes and metabolic disease..
thumb-pub-naturally-diabetic-nhps Read More Publication Naturally Diabetic NHPs – The Most Predictive Animal Model for Human Disease Various animal models have been used in research for understanding diabetes and metabolic..
thumb-pub-ggi-c-peptide-decoonvolution-1 Read More Publication GGI and C-Peptide Deconvolution - Powerful Translational Tools for Diabetes.. Quantitation of β-cell function is critical to better understand the dynamic interactions of..
thumb-pub-xylazine-causes-acute Read More Publication Xylazine Causes Acute Hyperglycemia in NHPs The α2-adrenoceptor agonist xylazine has been widely used as an anesthetic in veterinary clinics..
thumb-pub-ccrcc-intra-tumor Read More Publication ccRCC Intra-Tumor Molecular Heterogeneity Influences Targeted Therapy Response Both inter- and intra-tumor molecular heterogeneity are increasingly being recognized in clear..
thumb-pub-optimizing-inhimbitors Read More Publication Optimizing Inhibitors for RET Rearranged Tumors The targeted inhibition of oncogenic driver mutations is an underlying principle of oncology..
thumb-pub-intro-to-preclincial-immuno Read More Publication Introduction to Preclinical Immuno-Oncology In Vivo Models Immuno-oncology research has dramatically increased over the past few years, due to the clinical..
thumb-crc-sensitivity Read More Publication CRC Sensitivity to Proteasome Inhibitor Investigated Colorectal cancer (CRC) has a low 5 year survival rate, due to the late diagnosis of advanced..
thumb-pub-first-in-class-pikfyve Read More Publication First-in-Class PIKfyve Kinase Inhibitor for B-NHL Identified Non-Hodgkin lymphoma (NHL) covers a group of lymphoproliferative malignancies with subtypes..
thumb-pub-first-stable-serially Read More Publication First Stable, Serially Transplantable M5 AML PDX Model Patient-derived xenografts (PDX) have proven to be useful preclinical research tools across many..
thumb-expression-based-ras Read More Publication Expression Based RAS Pathway Predicts CRC Cetuximab Response Cetuximab is approved for the treatment of metastatic colorectal cancer (mCRC), excluding..
thumb-pub-confirmed-high-relevance Read More Publication Confirmed - High Relevance of PDX as Surrogate Experimental Models The accurate diagnosis of cancer types is needed to understand disease development and..
thumb-pub-nsclc-pdx-models Read More Publication NSCLC PDX Models with EGFR Exon 20 Insertions Developed Activating EGFR mutations are oncogenic drivers in a significant proportion of NSCLC cases...
thumb-pub-novel-ex-vivo-3d-tumor Read More Publication Novel Ex Vivo 3D Tumor Growth Assay for PDX Developed It is increasingly recognized that preclinical models do not fully reflect the tumor..
thumb-pub-design-and-optimization Read More Publication Design and Optimization of DAAP ALK Inhibitors Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the insulin receptor..
thumb-pub-oncogenic-allele Read More Publication Oncogenic Allele Signature Predicts CRC Cetuximab Response Cetuximab is an approved standard of care agent for EGFR+ metastatic colorectal cancer (mCRC),..
thumb-pub-new-daap-alk-1 Read More Publication New DAAP ALK Inhibitor Series Discovered Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that belongs to the insulin..
thumb-pub-metastatic-gastric-neuroendocrine-3 Read More Publication Metastatic Gastric Neuroendocrine Carcinoma PDX Model Developed Patient-derived xenograft (PDX) models show improved predictability for drug development..
thumb-pub-cancer-stem-cells-targeted-1 Read More Publication Cancer Stem Cells Targeted by PI3K/mTOR Inhibitor Cancer stem cells (CSC) are implicated in chemoresistance, as well as disease metastasis,..
thumb-pub-predicting-cetuximab-1 Read More Publication Predicting Cetuximab Response in Gastric Cancer using MCT Gastric cancer (GC), specifically gastric adenocarcinoma, is one of the leading causes of cancer..
thumb-pub-novel-multitarget-kinase-1 Read More Publication Novel Multitarget Kinase Inhibitor for HCC and GC Discovered Protein kinases are successful therapeutic targets in oncology, validated by the broad..
thumb-pub-vegi-potential-tumor Read More Publication VEGI is a Potential Tumor Suppressor in RCC While vascular endothelial growth inhibitor (VEGI) has been associated with tumor-related..
thumb-pub-overcome-efgr-tki Read More Publication How to Overcome EGFR TKI Resistance in NSCLC EGFR tyrosine kinase inhibitors (TKI) including erlotinib have provided significant clinical..
thumb-pub-optimization-of-hdac Read More Publication Optimization of HDAC Inhibitors for HCC Hepatocellular carcinoma (HCC) is among the leading causes of cancer death worldwide, with poor..
thumb-fs-rodent-cardiovascular Read More FactSheet Rodent Models of Cardiovascular Disease Rodent models of cardiovascular disease technologies and resources including continuous..
thumb-fs-zdsd-rat Read More FactSheet ZDSD Rat Factsheet The ZDSD polygenic rat model with functional leptin pathway, a highly translatable model which..
thumb-fs-rodent-models-diabetes Read More FactSheet Rodent Models of Diabetes Rodent models of diabetes and our study services including continuous glucose determination.
thumb-ms-nash-factsheet Read More FactSheet MS-NASH Mouse Model The MS-NASH (FATZO) polygenic mouse model with functional leptin pathway, a more translatable..
thumb-fs-spontaneously-diabetic-nhps Read More FactSheet Spontaneously Diabetic NHPs Spontaneously diabetic NHPs which mirror human disease phenotype, metabolic defects, and..
thumb-fs-nafld-nash Read More FactSheet NAFLD/NASH in the MS-NASH Mouse The MS-NASH model, which develops NAFLD/NASH in an inherently dysmetabolic, obese, and diabetic..
thumb-fs-rodent-models-obesity Read More FactSheet Rodent Models of Obesity Rodent models of obesity technologies and resources including our main study endpoints.
thumb-fs-non-human-primate-obesity Read More FactSheet Non-Human Primate Models of Obesity Spontaneous and diet-induced NHP models of obesity allowing research on metabolic dysfunction..
thumb-renal-desease-rodent-models Read More FactSheet Rodent Models of Renal Disease Rodent models of renal disease including genetically relevant, translatable, and induced disease..
thumb-fs-non-glp-toxicology-safety-2 Read More FactSheet Non-GLP Toxicology and Safety Pharmacology Studies CrownBio also provides details on our comprehensive Non-GLP Toxicology and Safety Pharmacology..
thumb-fs-car-t Read More FactSheet CAR-T Therapy Preclinical evaluation of CAR-T therapies in vivo using our novel Patient-Derived Xenograft..
thumb-fs-utilizing Read More FactSheet Utilizing Cell Line Derived and Patient-Derived Xenografts in Humanized NSG™.. Evaluating Cell Line Derived Xenograft and PDX models in humanized mice, including immune memory..
thumb-fs-mixeno Read More FactSheet MiXeno™ MiXeno™ models featuring transient human immunity in mice, providing a simple alternative to the..
thumb-fs-hugemm-hucell Read More FactSheet HuGEMM™ and HuCELL™ Models HuGEMM™ and HuCELL™, our unique platforms for evaluation of targeted human-specific..
thumb-fs-syngeneic Read More FactSheet Syngeneic Models Syngeneic models, showcasing our ever expanding syngeneic collection, FACS analysis, and..
thumb-fs-muscreen Read More FactSheet MuScreen™ MuScreen™ CrownBio’s large-scale, screening platform to fast-track the in vivo screening of..
thumb-fs-muprime Read More FactSheet MuPrime™ Model MuPrime™ - homografts of spontaneous murine tumors (from GEMM/carcinogen-induced models),..
thumb-fs-ret Read More FactSheet RET Fusion RET fusion in CRC PDX models, including model response to RET inhibitor treatment, and the..
thumb-fs-fgfr3 Read More FactSheet FGFR3 Fusion In Vivo Xenograft Platform Our FGFR3 fusion in vivo xenograft platform covering both patient and cell line derived..
thumb-fs-huprime Read More FactSheet HuPrime® Our PDX collection key features are summarized in our HuPrime® FactSheet
thumb-fs-hukemia Read More FactSheet HuKemia® Discover our validated stable HuKemia® models, the only commercial blood cancer PDX models to..
thumb-fs-gist Read More FactSheet GIST PDX Models Use the world's most comprehensive GIST PDX collection to evaluate the next generation of..
thumb-fs-nhl Read More FactSheet NHL DLBCL PDX Models Read how to accelerate NHL DLBCL targeted agent and combination therapy drug discovery programs..
thumb-odw-non-glp Watch Now On-Demand Webinar How to Maximize Your Non-GLP Toxicology Studies: A Guide for Optimal Design and.. Prior to clinical studies in humans, an investigational new drug (IND) application must be..
thumb-odw-nalfd-nash Watch Now On-Demand Webinar NAFLD/NASH: Strategies for Accelerating Drug Discovery with an Improved.. Metabolic disturbances such as insulin resistance, obesity, and dyslipidemia are prominent risk..
thumb-odw-platforms Watch Now On-Demand Webinar Translational Platforms to Model Pre-Diabetes, Diabetes, and Diabetic.. A key challenge in preclinical studies of diabetes is the lack of translational platforms that..
thumb-odw-vascular Watch Now On-Demand Webinar Vascular and Neural Complications in Rodent Models of Obesity and Type 2.. Peripheral neuropathy affects around 50% of the diabetic population. Manifestations range from..
thumb-odw-microbiome Watch Now On-Demand Webinar Microbiome Drug Development with Whole Communities and Defined Consortia Microbiome therapies are still in their infancy, but are rapidly advancing into clinical testing..
thumb-fs-mubase Read More FactSheet MuBase® Use our unique online database MuBase® to quickly and easily identify the most suitable murine..
thumb-odw-right-model Watch Now On-Demand Webinar Are You Choosing the Right Model? A Guide to Selecting Your Next.. Recent regulatory approvals and fast-track designations have signified the coming of age of..
thumb-odw-beyond-syngeneics Watch Now On-Demand Webinar Beyond Syngeneics – Novel Tools for Addressing Human Specificity in.. Checkpoint inhibitors such as anti-PD-1, anti-PD-L1, and anti-CTLA-4 have revolutionized..
thumb-odw-clinically-relevant Watch Now On-Demand Webinar Clinically Relevant Cell-Based Solutions for Target Identification Target identification studies play a critical role in the early stages of cancer drug discovery..
thumb-fs-3d-cell Read More FactSheet 3D Cell Culture Platform In Vitro/Ex Vivo Assays for Cancer Pharmacology Our 3D cell culture platforms described in detail, including the 3D tumor growth assay (3D TGA)..
thumb-odw-exploring-translational Watch Now On-Demand Webinar Exploring Translational Capabilities of PDX Models across In Vivo, In Vitro and.. The development of novel cancer therapies to take into the clinic requires significant..
thumb-odw-immuno-oncology Watch Now On-Demand Webinar Immuno-Oncology: 3 Strategies for Applying Humanized Models The evaluation of human specific immunotherapeutics is hampered by a lack of preclinical..
thumb-odw-exvivo-invitro Watch Now On-Demand Webinar In Vitro and Ex Vivo Assays to Accelerate Immuno-Oncology Drug Discovery Immunotherapy represents one of the most promising cancer treatment approaches in modern..
thumb-odw-syngeneic-models Watch Now On-Demand Webinar Interrogating Syngeneic Models in Large Scale, How to Use Immunoprofiling Data.. Syngeneic models are a standard preclinical platform for evaluating immunotherapies. However,..
thumb-odw-mct Watch Now On-Demand Webinar Mouse Clinical Trials: The Power Behind Study Design It is widely known that the attrition rate of oncology drugs in the clinical setting can be..
thumb-odw-murine Watch Now On-Demand Webinar Murine Immuno-Oncology Models: A Head-to-Head Comparison Between Syngeneics and.. Syngeneics have been the mainstay model for surrogate immunotherapy evaluation as an..
thumb-odw-xenografts Watch Now On-Demand Webinar Patient-Derived Xenografts: New Advancements in Preclinical Prostate Cancer.. Prostate cancer is a highly heterogeneous disease, with extremely complex biological, hormonal,..
thumb-odw-mouse-clinical-trials Watch Now On-Demand Webinar The Ultimate Guide to Mouse Clinical Trials The cost of bringing a new drug to market carries a high price, however it is even more costly..
thumb-app-note-hutrial Read More Application Note HuTrial™ Case Studies CrownBio presents a variety of interesting and diverse mouse clinical trials, using our PDX..
thumb-invitro-exvivo Read More Application Note In Vitro and Ex Vivo Immuno-Oncology Drug Discovery Discover how CrownBio’s comprehensive Immuno-Oncology platform allows end-to-end in vitro and ex..
thumb-qf-ms-nash Read More Quick Fact MS-NASH mouse Highly translatable model for diabetes, obesity, and metabolic syndrome
thumb-nhp-models Read More Quick Fact NHP models of obesity Spontaneous and diet-induced models for obesity research
thumb-pkd-qf Read More Quick Fact PKD models Human disease relevant mouse model of polycystic kidney disease
thumb-nhp-1 Read More Quick Fact Spontaneously diabetic NHPs The most translatable animal model in Type 2 diabetes research
thumb-zdsd Read More Quick Fact ZDSD rat Highly translatable model for obesity, metabolic syndrome, diabetes, and diabetic complications
thumb-qf-inflammation-ibd-models Read More Quick Fact IBD Models Preclinical platform to advance inflammation drug discovery
thumb-qf-inflammation-ra-models Read More Quick Fact RA Models Translational preclinical platform to speed RA drug discovery
thumb-3d-pdx Read More Quick Fact 3D PDX Screen A rapid translational ex vivo screening platform
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thumb-wp-nafld-nash Read More White Paper NAFLD/NASH: Accelerating Drug Discovery with an Improved Metabolic.. Nonalcoholic steatohepatitis (NASH) is an increasing public health issue, with no currently..
thumb-wp-cardiovascular Read More White Paper Translational Platforms to Model Pre-Diabetes, Diabetes, and Diabetic.. Modeling human diabetes in animal models is challenging – currently available models only mimic..
thumb-wp-translational Read More White Paper Exploring Translational Capabilities of PDX Models across In Vivo, In Vitro,.. Patient-derived xenografts are recognized as the most predictive preclinical model available for..
thumb-wp-immuno-oncology Read More White Paper How to Choose the Correct I/O Model As immuno-oncology continues to grow as a therapeutic area, more preclinical research is driven..
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thumb-wp-clincial-trials Read More White Paper The Ultimate Guide to Mouse Clinical Trials Traditional oncology drug development strategies are failing – oncology agents have a higher..
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