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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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  • Platforms
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CRISPR/Cas9 gene editing platform

The CRISPR/Cas9 system is a cutting-edge gene editing technology that allows for precise and efficient editing of a cell's DNA. This revolutionary technology has made a significant impact in the world of drug discovery with its simplified editing capabilities and minimal off-target effects. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies, enabling you to model diseases using stable knockouts/knock-ins and test the efficacy of your drugs with confidence.

These services offer a comprehensive solution for cancer disease modeling. With an extensive collection of cancer cell lines and follow-up studies using tumor organoids, you can be confident in the reliability of your research results.


Customized features for your research needs:

  • Extensive Biobank of Models: Choose from hundreds of well characterized cell lines, PDX-derived organoids, and adult stem cell patient derived organoids:

  • Ready To Use: Off-the-shelf engineered cell line selection for an already available option. Choose a custom build, or bypass initial cell line generation with one of our XenoBase cell lines, complete with characterization and data selection

  • In Vivo Validation Services: Use our extensive database of complex 3D organoid models (OrganoidBase) to later validate your compounds in vivo

  • Vector Controls: Confirm your downstream results with our robust quality controls
  • Commercially Available Cell Lines: Representing multiple tissues, hundreds of cell types, and reporter genes
  • Ready to use lentiviruses: Integrating and non-integrating options (allowing requirement for only a biosafety level 2 [BSL-2] facility)
  • Endogenous Tags: Luciferase tag options

CRISPRCas9 Cell Engineering Workflow Image


    • CRISPR Applications

    • Disease modeling: Capture disease relevance and patient population heterogeneity

      Viral host factor identification: Better understand the molecular mechanisms underlying viral entry, replication and pathogenicity

Predictive biomarker identification: Determine potential biomarkers of therapeutic response with companion diagnostics

Immunotherapy assessment: Utilize immune checkpoint inhibitor resistant models for compound validation

Bridging in vitro and in vivo: Ease your study transitions from in vitro studies with vivo validation

Gene modification for gain- or loss-of-function studies: Run a conclusive experiment that allows you to quickly validate or invalidate your gene target

Phenotypic assessment: Assess if a phenotype is specific to a particular protein or if a gene target provides the same phenotype in multiple cell types

Study Options

Accelerate your discoveries with our reliable CRISPR solutions. Our milestone-measured process ensures that data is provided at key intervals, overcoming any limitations prior to project advancement. Your project can be fully customizable to ensure seamless delivery. 


  • Gene Knockout and/or Gene Knock-in: Introduce your CRISPR components into cells via one of our several transfection methods: Lipofection, electroporation, nucleofection, or lentiviral transfection

  • Single Point Mutations: Screen for mutations that affect protein function, or add tags to endogenous proteins in cell lines. Studies include in vitro drug screenings, mechanism of action, and biological function.

  • Knockdowns: Reduce the expression of your gene with SiRNA and ShRNA transient and stable options

  • Knock-out cell pools: Initiate your test at lower cost with a cell pool. We use CRISPR transfection to express Cas9 and cell pool testing to confirm presence of Cas9

  • Biomarker analysis, genome sequencing, and validation: Conduct standalone in vitro and/or follow up with in vivo model validation services

  • Lead Screening and optimization: Option to use reporter/disease modeling cell lines or cell line derived xenograft models

  • Efficacy Testing: Leverage both 2D and 3D models to quantify efficacy across patients and compounds and predict in vivo response. Leverage high content imaging services to produce highly comprehensive morphology readouts
  • Ready to Use: Ready-to-transfect predesigned sgRNAs or use custom designed SgRNA and HDR template

Large Scale Cancer Screening


Accelerate the drug development process and advance your lead compound to a validated candidate with Crown Bioscience's OmniScreen. This cost-effective, high-throughput screening platform allows for rapid screening of over 500 cancer cell lines to provide key information on cytotoxicity and chemotherapeutic potential. With quarterly revivals of cell lines and positive drug control and cell line revival costs included, you can maximize savings and choose from a variety of focused screening panels, including OmniPanel™, XenoSelect™, RNAseq Panel, and PrimePanel™. Customize your study with flexible template designs and receive bioinformatics support throughout the process. Start your drug screening journey here.

High Content Services


Get deeper insights with a suite of powerful 3D in vitro imaging-based assays that recapitulate and quantify complex human biology in a robust and high-throughput imaging platform. Follow up with assisted high content analysis study options.



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