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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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Cell Line Derived Xenograft Models

A global platform of validated and advanced in vivo models to progress your drug discovery to the next level

Decision Making Made Easy with our Validated In Vivo Xenograft Models

As an integral step in the oncology drug discovery process, cell line derived xenograft models provide key decision-making information to allow an agent to move forward, and clients to advance their preclinical development programs in a timely and cost-effective manner.

Crown Bioscience has established multiple in vivo assay systems to evaluate novel anticancer compounds, with each assay specifically designed to understand a drug's mechanism of action, or an individual agent property.

Rapidly Find Your Models of Interest

Working with Crown Bioscience gives you access to XenoBase®, our online collated database of well-characterized cell lines and cell line derived xenograft models, which includes standard of care and RNAseq data to enable easy model selection.

ValidatedXeno™ Models

Over 200 validated and well-characterized cell line derived xenografts covering subcutaneous, orthotopic, and systemic models.

The collection includes metastasis models (spontaneous and experimental) covering major cancer types such as:

Breast Lung Pancreatic
Colon Melanoma Prostate
Liver Ovarian  

PDX-Derived Xenograft Models - PrimeXeno™

These unique models are derived from our HuPrime® patient-derived xenograft (PDX) models, via cell lines. Many of these models harbor mutations of novel therapeutic targets, such as:

ALK FGFR2 FLT3 R-spondin (RSPO3)


PrimeXeno models are ideal for early stage drug discovery, where a robust system is needed to screen large numbers of compounds in assays such as PK/PD analysis.

Nude Rat Xenograft Models

Nude rat xenograft models are recognized as an attractive option compared to mouse models, because a compounds’ PK properties are typically closer to that observed in humans.

Crown Bioscience has validated both subcutaneous and orthotopic nude rat xenograft models, covering:

  • Solid tumors
    • bladder, colon, glioblastoma, and prostate cancer
  • Non-solid tumors
    • AML and myeloma

In Vivo Imaging

Crown Bioscience provides bioluminescent subcutaneous, orthotopic, and metastatic cell line derived xenograft models for optical imaging.

These models provide valuable disease information at different cancer stages, through orthotopic models mimicking primary lesions, to the imaging of both spontaneous and experimental metastases to replicate progression to late stage disease.

Bioluminescent PC-3M-luc Orthotopic Prostate Cancer Model Tumor Growth Inhibition Following Docetaxel Treatment

Bioluminescent PC-3M-luc Orthotopic Prostate Cancer
Model Tumor Growth Inhibition Following Docetaxel Treatment

Specialty Models Available

  • Dual xenograft models. Validated pairs of models that may be engrafted on the same mouse without interfering with each others growth, used for assessing the selectivity of targeted agents.
  • Engineered in vivo models. BaF3-EML4-ALK-WT and the paired, engineered BaF3-EML4-ALK-L1196M as well as BaF3-BCR-ABL-T315I  available.*

Discuss Your CDX Models Project

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*BaF3 cell lines must be licensed directly by clients