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Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.
Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.
Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.
Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.
Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.
Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.
Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.
Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.
Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.
Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.
Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.
Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.
Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.
Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.
Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.
Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.
Certified CRO services with NanoString GeoMx Digital Spatial Profiling.
De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.
Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.
Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.
Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.
Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.
Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.
Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.
Learn more about how our consulting services can help to support your journey to the clinic.
Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.
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From conventional cell lines to CDX, to patient-derived xenograft (PDX) and organoid models, we have the widest range of oncology model systems available today. Whether you’re in the discovery, preclinical or translational phase of drug development, the Crown Bioscience team will partner you need to advance your oncology molecule.
Built upon a solid foundation of oncology experts and quality standards that surpass operational need, our facilities in the USA, China and Europe are strategically located to serve all major research markets. This enables our industry leading response times to initiate studies in days, not weeks, and for our customers to partner with study managers in any location.
Combining innovation with breadth, depth, and capacity, we deliver the world’s premier Translational Oncology Drug Discovery Platforms helping our customers to increase successful clinical candidates.
Whatever your project needs, we have the in vitro biology platform to support faster, better decision-making for your oncology drug discovery program.
Our expert team have extensive experience of working with companies to support the in vitro pharmacology characterization of lead compounds and are committed to saving you precious time and resources by providing efficient screening platforms and validated 2D and 3D models, giving you confidence in your data.
Utilize the XenoBase®, the world’s largest commercial database of well-characterized cell lines to choose the correct cell lines for in vitro evaluation of your novel molecules.
Incorporate the most translatable 3D in vitro models available into your oncology drug development programs with our exclusive Hubrecht Organoid Technology (HUB) licence.
Use cost-effective, rapid, and large-scale cancer cell line screening to advance your lead compound to validated candidate
Detect more than 500 different morphological parameters of 3D in vitro models using our powerful high content screening services
With an industry-leading 3000 PDX models available, we are committed to advancing your preclinical development programs in a timely and cost-effective manner.
Partner with us to select the most appropriate platform, study design, and screening method tailored to each of your individual drug candidates and research question. Each of our models are supported by a range of translational tools including biomarker, in vitro/ex vivo assays, and in silico modelling to optimize lead candidates.
Leverage our unrivalled collection of PDX models, derived directly from patient tumors to reflect the heterogeneity and diversity of the human patient population
Make key decisions in a timely and cost-effective manner about the progression of your preclinical development program with cell line-derived xenograft (CDX) models.
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2024-01-29
2021-10-22
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