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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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Targeting Resistance to Advance Preclinical Oncology Drug Discovery

Expert Solutions for Tackling Drug Resistance Challenges

Our streamlined project management and advanced consulting services are designed to assist you in designing, evaluating, and reviewing your preclinical development plans, ensuring efficiency and minimizing repetitive tasks. Utilizing our consulting services, you gain in-depth assistance for scientific inquiries, study design execution, and integrated services to evaluate the efficacy and mechanism of action of your therapeutics, specifically addressing drug resistance challenges.

Using our four-step approach, you gain access to comprehensive preclinical models, searchable oncology databases, advanced biomarker analysis, and CAP-accredited laboratories, all designed to enhance the precision and effectiveness of your drug development efforts, particularly in overcoming drug resistance.

Transforming Cancer Drug Resistance

Overcome drug resistance in your preclinical research with our diverse models, including patient-derived xenografts (PDX). Use our oncology databases to find the most relevant models and access extensive profiling and pharmacologic data. Enhance your research with advanced biomarker analysis, multi-omics, spatial biology assays, and data science platforms, driving effective drug discovery.



Four-Step Preclinical Strategy to Tackle Cancer Drug Resistance

Explore multiple solutions for optimal drug resistance model development

Our unique four-step approach offers personalized strategies to address various drug resistance challenges, facilitating the successful acceleration of your project. By analyzing intrinsic and acquired resistance across diverse therapeutic types and molecular targets, we craft tailored solutions that enhance treatment efficacy.

Integrated Services Approach to Developing New and Clinically Relevant Models

Navigate the complexities of drug resistance using our strategic solutions and robust resources, designed to accelerate your drug development journey, ensuring you achieve success with greater efficiency.

Our customized integrated solutions provide you with a comprehensive suite of resistance models across in vitro, in vivo, ex vivo, and in silico platforms, supported by a living biobank of over 30 cancer types. Our ongoing R&D efforts continually expand our catalog, and we offer custom model development to meet specific research needs. By integrating biomarker strategies, we help predict clinical responses, enabling the identification of translatable solutions and accelerating research progress.

Our Customers Love Us

We are proud to boast the best Customer Experience in the Industry, explore our data below.

Studies <br>Completed


This data point indicates the total number of studies in Q2 2023 that the CSAT, Customer Effort, and Customer Expectation scores are measured against.



Customer <br>Satisfaction


Also known as CSAT, this metric indicates how satisfied customers are with the complete Crown Bioscience customer experience.



Customer <br>Effort


The Customer Effort Score (CES) is a metric that measures how easy it was to work with Crown Bioscience.



Explore our monthly Customer Satisfaction Report

Discuss Your Drug Resistance Project

Related Resources



Clinically Aligned Pretreated PDX Models



Combating Cancer Drug Resistance with In Vivo Models


Application Note

HCC827 NSCLC Cell Line Derived Xenograft Model