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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Target to Lead Selection for ADCs and Biologics

Journey through the drug discovery pipeline from target discovery to in vivo pharmacology. Take advantage of the Largest biobank of patient-derived models, Model development capabilities, Cell-based assays for Screening ADCs, and advanced downstream analysis.

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Immuno-oncology Targets & Combinations

Leverage comprehensive in vitro, in vivo, ex vivo, and in silico platforms, utilizing immunocompetent, humanized, or patient-derived models. With robust biomarker analysis and a focus on checkpoint inhibitors, you can optimize combination strategies.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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PDX Mouse Clinical Trials

Translational Models, Predictive Biomarkers, New Indications, Deeper Drug Insights

The Challenge: Enhancing Clinical Translation in Oncology Drug Development

Many oncology therapies fail in clinical trials—especially in Phase II—due to a lack of efficacy. This underscores the need for more predictive preclinical models that better mirror human responses and improve clinical trial success rates.

Our Solution: PDX Mouse Clinical Trials (MCTs)

(Previously known as HuTrial)

Patient-Derived Xenograft (PDX) Models are transforming preclinical oncology research by offering more clinically relevant data. By preserving the key features of patient tumors, PDX models provide a powerful tool for drug development and clinical translation. These models help bridge the gap between preclinical studies and clinical success, offering oncology drug developers a reliable pathway to more accurate predictions and outcomes.

HuBase™: The World’s Largest Collection of Clinically Relevant PDX Models

Access 2,500+ global PDX models. Tailor your selections based on indication, drug responses, patient histories, and multiomics data for precision in your studies.

Figure. A representative PDX Mouse Clinical Trial DesignFigure. A representative PDX Mouse Clinical Trial Design

Why Choose PDX Mouse Clinical Trials?

Enhancing Oncology Drug Development with Predictive Models

PDX Mouse Clinical Trials offer a unique advantage for oncology drug developers by providing:

  • Better Clinical Translation: PDX models closely mimic human tumor biology, maintaining key features such as the genetic and phenotypic characteristics of patient tumors, leading to more accurate predictions of clinical outcomes.
  • Predictive Biomarker Discovery: These models help identify biomarkers for patient stratification, enabling more personalized treatment strategies and increasing the likelihood of clinical trial success.
  • Exploration of New Indications: PDX models allow for the evaluation of therapies across diverse tumor types, uncovering potential new therapeutic applications and expanding indications.
  • Deeper Drug Response Insights: Gain a deeper understanding of drug efficacy, mechanisms of action (MoA), and resistance mechanisms. PDX models are invaluable for optimizing drug combinations and reducing attrition in clinical development.

Why Choose Crown Bioscience for PDX Mouse Clinical Trials?

The PDX Expert:

  • Largest Commercial PDX Collection and Quality
    • Better representation of patient populations
    • > 500 live PDX models for fast track service
    • Patented NGS QC Method ensures the highest PDX model quality
  • Accurate Biomarker Assay & Data Interpretation
    • Our specialized methodologies ensure precise biomarker analysis, even with complex mixed tumor tissues in PDXs1-3

MCT Data Science Expert Support:

  • Bioinformatics Expertise
    • Expert design of optimized, cost-efficient, data-driven MCTs4
  • Tailored Bioinformatics Consultation
    • Receive biostatistical and bioinformatics support, including model selection and study design consultation.
  • End-to-End Service
    • Complete support from trial design to data analysis, ensuring seamless execution
Crown Bioscience for PDX Mouse Clinical Trials Fig. End-to-end MCT Data Science Expert Support

Rely on the Experts for Accurate PDX Biomarker Insights

PDX models are among the most predictive of patient tumors, but they come with unique challenges. After human tumor fragments are engrafted into immunodeficient mice, human stroma is quickly replaced by mouse cells, including immune components and blood vessels. This can complicate biomarker analysis and data interpretation, potentially leading to misleading results if human and mouse signals aren’t properly distinguished1,2.

With our deep expertise and a proven track record of publications1-3, Crown Bioscience leads the field in overcoming these challenges, delivering reliable, actionable insights that drive successful oncology research.

Xenografts
BLOG

Are You Doing Proteomics Correctly for Xenografts?

Delivering Comprehensive Solutions in PDX Mouse Clinical Trials

Our PDX Mouse Clinical Trials are designed to maximize the impact of your oncology research by offering:

  • Optimized Clinical Trial Designs: Tailored to maximize predictive power and ensure clinical relevance, setting your studies up for success in oncology drug development.
  • Integrated Data Reports: Our comprehensive reports combine biomarker discovery, PK/PD analysis, and bioinformatics to provide a holistic view of your study's outcomes.
  • Seamless Service: From trial initiation to final report, our dedicated team ensures consistency, quality, and efficiency at every stage, empowering you to confidently advance in your drug development journey.
Step by Step Guide for Mouse Clinical TrialFigure. Step by Step Guide for Mouse Clinical Trial

Applications of PDX Mouse Clinical Trials in Oncology

PDX Mouse Clinical Trials support diverse oncology research areas, helping to drive better clinical translation and drug development outcomes:

  • Biomarker Discovery & Validation: Identify biomarkers for personalized treatment strategies, improving patient stratification and increasing clinical trial success.
  • Clinical Stratification: Generate precise data to support targeted therapies, improving patient selection and enhancing treatment efficacy.
  • Exploring New Indications: Investigate therapies across various cancer types, discovering new therapeutic uses and expanding treatment possibilities.
  • Targeted Research: Focus on specific genetic mutations or cancer drivers to refine therapeutic approaches and advance precision medicine.
  • Drug Combination Strategies: Evaluate drug combinations to overcome resistance and optimize treatment responses, backed by our innovative in vivo synergy assessments for enhanced 

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The Ultimate Guide to PDX Mouse Clinical Trials

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How to Optimize Mouse Clinical Trials Through Statistical Endpoints and Study Design

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References

1. Wubin Qian, Xiaobo Chen, Yanghui Sheng, Likun Zhang, Jingjing Wang, Zhenzhen Song, Qi-Xiang Li, Sheng Guo; Tumor Purity in Preclinical Mouse Tumor Models. Cancer Research Communications 2 May 2022; 2 (5): 353–365. https://doi.org/10.1158/2767-9764.CRC-21-0126

2. Zhaomei Shi, Binchen Mao, Xiaobo Chen, Piliang Hao, Sheng Guo; Mouse Stromal Cells Confound Proteomic Characterization and Quantification of Xenograft Models. Cancer Research Communications 1 February 2023; 3 (2): 202–214. https://doi.org/10.1158/2767-9764.CRC-22-0431

3. Huajun Zhou, Binchen Mao, Sheng Guo; Mathematical Modeling of Tumor Growth in Preclinical Mouse Models with Applications in Biomarker Discovery and Drug Mechanism Studies. Cancer Research Communications 2024; https://doi.org/10.1158/2767-9764.CRC-24-0059

4. Sheng Guo, Xiaoqian Jiang, Binchen Mao, Qi-Xiang Li. The design, analysis and application of mouse clinical trials in oncology drug development. BMC Cancer 19, 718 (2019). https://doi.org/10.1186/s12885-019-5907-7

5. Binchen Mao, Sheng Guo; Statistical Assessment of Drug Synergy from In Vivo Combination Studies Using Mouse Tumor Models. Cancer Research Communications 2 October 2023; 3 (10): 2146–2157. https://doi.org/10.1158/2767-9764.CRC-23-0243