Human Biospecimen Solutions | Crown Bioscience

Crown Bioscience offers a globally-sourced, IRB-approved human biospecimen biobank, purpose-built for translational and precision oncology research. Our biobank includes high-quality tumor tissue, matched adjacent normal, plasma, serum, and PBMCs—collected under standardized, compliant protocols with ultra-short ischemia times to preserve molecular fidelity.

Leveraging an international clinical network across North America, Europe, and Asia, we deliver biospecimens paired with clinical data—diagnosis, staging, treatment history, outcomes and more—to support multi-omics applications, including biomarker discovery, drug response profiling, and diagnostic assay development.

Limited-Time Year-End Promotion: Unlock Special Pricing for Your Research

For a limited time, secure high-quality human biospecimens (FFPE, Plasma, Tissue) from the Crown Bioscience biobank at a significant discount. Offer expires Dec 25, 2025.

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Biospecimen Quality, Compliance, and Clinical Relevance

Crown Bioscience delivers rigorously controlled, high-quality human biospecimens collected under IRB-approved protocols and standardized preanalytical workflows to ensure consistency and reproducibility across research applications.

These strict standards safeguard the biological relevance of our samples, enabling researchers to confidently advance multi-omics profiling, biomarker discovery, and clinical assay development with high translational value.

Minimal ischemia time and controlled handling to preserve RNA, DNA, and protein integrity
Board-certified pathology review and histological validation for every tissue specimen
Detailed clinical data, including demographics, diagnosis, treatment history, and outcomes
Ethical and regulatory compliance with HIPAA, GDPR, and Good Clinical Practice (GCP) standards
Preservation formats tailored for downstream applications—FFPE, fresh-frozen, viable tissue, and blood-derived components

Available Specimen Types and Formats

Our biobank offers a comprehensive inventory of human biospecimens sourced from diverse cancer indications and healthy donors. All samples are preserved using validated workflows and are available in a range of formats to support specific research goals. All biospecimens are linked to extensive clinical metadata, including diagnosis, stage, treatment history, and outcome data, enabling integration into advanced multi-omics workflows.

Tissue Samples

Fresh-frozen or FFPE tumor tissue
Matched adjacent normal tissue
Tumor Tissue Microarray (TMA)
Available across multiple cancer types (e.g., colorectal, NSCLC, breast)

Blood-Derived Samples

Plasma, serum, buffy coat, PBMCs
Longitudinal collections available for time-course studies
Suitable for ctDNA, proteomics, cytokine profiling, and more

Custom Collections

Prospectively collected fresh tumor and adjacent normal tissue samples based on protocol specifications
Disease-state specific or treatment-naïve samples upon request
Tailored cohort design with IRB oversight

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Disease Indications and Molecularly Stratified Cohorts

Our extensive biobank features well-characterized cohorts from treatment-naïve, refractory, and relapsed patient populations—designed to support targeted therapy development, immuno-oncology research, and biomarker validation. This stratification enables researchers to select highly relevant biospecimens for retrospective cohort analysis, predictive biomarker development, and multi-omics correlation studies to increase translational relevance and accelerate their insights.

Our oncology specimen portfolio includes, but is not limited to:

Non-Small Cell Lung Cancer (NSCLC)
Breast Cancer
Prostate
Colorectal Cancer (CRC)
Liver
Pancreatic
Ovarian
Melanoma and Other Solid Tumors

Sub-cohorts can come with high-value clinical and molecular data:

Driver mutations: EGFR, KRAS, BRAF, PIK3CA, and others
Treatment history: First-line, second-line, and beyond
Histopathology and tumor content confirmation

Unlock Deeper Insights With Multi-omics Quality Tissue

Our biobank stands apart with ultra-short ischemia times, ensuring unmatched traceability and reliability. Each sample is enriched with over 300 clinical data points, providing an in-depth view of patient outcomes and follow-ups. Comprehensive datasets, including tumor characteristics, therapy response, and biomarker status, empower researchers to drive meaningful insights. This commitment to high-quality, clinically annotated samples is instrumental in achieving replicable results in oncology research.

ON DEMAND WEBINAR

Biospecimens & Multi-Omics in Clinically Relevant Research

Join our experts to explore how our biospecimens—collected with rapid ischemia control and standardized protocols—can supercharge your research.

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Katharina Krohn

Senior Director, Global Biobanks

Snehal Padhye PhD MBA

Director, Scientific Engagement

Multi-Omics Grade Biospecimens

Designed for genomic, transcriptomic, proteomic, and spatial biology applications, our multiomics collection sets the bar for advanced analysis:

Preservation Excellence: Ultra-short cold ischemia ensures DNA/RNA/protein integrity
Low sample failure: Consistent performance in sequencing, mass spec, and spatial workflows
Rich datasets: Includes tumor subtype, therapy response, biomarker status, and outcomes
Ideal for: Biomarker discovery, companion diagnostic development, integrative multi-omics, spatial transcriptomics

Standard Grade Biospecimens

Optimized for high-throughput screening, diagnostic validation, and cost-conscious projects, our standard grade maintains stringent quality with practical scale:

Real-world sourcing: Collected from trusted clinical pathology networks
High-volume utility: Suited for large cohort studies, assay validation, surveillance
Cost-effective: Efficient choice for screening pipelines
Ideal for: Diagnostic assay development, epidemiological studies, high-throughput proteomics

Sample Collection and Processing

Our proprietary Oncology Biobank is a meticulously curated collection of human biomaterials and comprehensively associated clinical data, forming a critical resource for oncology research. Key features include:

Global Clinical Network: Extensive partnerships ensure diverse and ethically sourced sample procurement.
Patient Confidentiality: Adherence to stringent international standards for patient data protection.
Rigorous Quality Management System:
- Pathological Verification: In-house pathologists perform Hematoxylin and Eosin (H&E) staining for quality control of all tissue samples.
- Standardized Collection Protocols: Uniform procedures across all collection sites ensure inter-sample comparability and reduce pre-analytical variability.

Our biospecimen collection and processing workflows are designed to uphold scientific rigor and regulatory compliance at every stage—from patient consent to long-term storage—ensuring sample fidelity for high-confidence research outcomes. View our quality-related accreditations and certificates here.

All samples are processed using standardized preanalytical protocols to minimize variability and maximize molecular integrity for downstream applications, including NGS, qPCR, IHC, spatial transcriptomics, and flow cytometry.

Advanced Sample Storage and Handling Infrastructure

We maintain state-of-the-art biobanking facilities designed for optimal sample preservation and integrity, located in Hamburg and Frederick, comprising of:

Freezer Systems: Approximately 40 freezers operating at −80∘C for long-term storage of plasma, serum and urine.
Cryo Tanks: Approximately 22 cryo tanks providing cryogenic storage at minimum −150∘C for FF tissue.
FFPE Cabinets: Dedicated storage for FFPE tissue at room temperature, maintaining morphology and molecular integrity.
Integrated Data Management: Robust systems ensure comprehensive tracking and accessibility of all stored biospecimens.

Chain of Custody & Data Integrity

We employ a fully traceable, barcode-based inventory system for real-time sample tracking and full chain-of-custody documentation, capturing:

Collection timestamps
Preservation and processing metadata
Temperature logs during handling and storage
Pathology verification and tumor content annotation

All biospecimens are accompanied by digitally linked clinical metadata to facilitate cohort selection, stratification, and integrative analysis.

Delivering the Industry’s Highest Clinical Biospecimen Quality - Our Global Clinical Network

Crown Bioscience provides access to an unparalleled resource for oncology research through its global clinical network. Connecting with top-tier oncology centers across Europe, the USA, and Asia, our network ensures the consistent collection of high-quality, highly annotated human biospecimens. This foundation is critical for researchers investigating tumor evolution, dissecting complex treatment responses, and discovering novel biomarkers.

By seamlessly integrating clinical expertise with advanced biobanking protocols, our network directly empowers the next generation of precision oncology research, accelerating breakthroughs in cancer diagnostics and therapeutics.

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Human Biospecimen Solutions for
Next-Generation Cancer Research

Limited-Time Year-End Promotion: Unlock Special Pricing for Your Research