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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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Organoids for Oncology Drug Development

Preclinical oncology drug development and validation services using tumor organoids and the HUB tumor organoid biobank.

Progress Oncology Drug Development with Organoids Developed using HUB Protocols

Make use of the great translatability of our 3D organoid models which show unprecedented patient response predictivity. Benefit from faster development and enhanced scalability of organoids. Model and mirror patient population diversity via screening multiple tumor organoid models simultaneously, and access both tumor and healthy organoids to evaluate in vitro data with clinically relevant drug potency and efficacy as well as off target effects.


  •  Proprietary culture methods: Highly refined culture methods developed using Clevers Lab HUB’s protocols via exclusive partnerships, providing proprietary services
  • Varied indications: Multiple organoids available for over 20 organ and tissue types
  • Amenable to genetic perturbation via gene editing techniques such as RNA interference or CRISPR/Cas to identify and validate biological targets and discover mechanistic biomarkers
  • Maximizing the efficiency of the organoid platform with powerful imaging technology to penetrate the 3D structure and visualize the dynamic interplay of cells and their response to drug candidates.
  • Matched models: Paired in vitro PDXO and in vivo PDX models provide improved predictivity and a more rapid and informed study transition
  • Clinically relevant models: Harnessing ASCs either directly from patients (PDOs) or from xenograft tissue (PDXOs) to recapitulate the complex architecture of in vivo tissue. Unlimited expansion for large-scale screens
  • Living biobanks: Organoid database which includes light microscopy, genomic, transcriptomic, and pharmacology data
  • Integrated radiotherapy capabilities: Drug-Radiation combination testing using organoids



  • Organoid Applications

  • Drug discovery and development: Test candidate efficacy, safety, side effects, and pharmacokinetic properties as well as mechanism of action
  • Safety and toxicity studies: Evaluate safety and toxicity profiles using healthy organoids, developed from non-transformed cells
  • Personalized medicine: Leverage HUB OrganoidsTM as patient epitomes to design targeted and personalized therapies and stratify your patient population
  • Disease modeling: Capture disease relevance and patient population heterogeneity
  • Bridging in vitro and in vivo: Identify your target patient population before entering the clinical trails
  • Predictive biomarker identification: Determine potential biomarkers of therapeutic response with companion diagnostics

Study Options

Preclinical oncology drug development and validation services using unique organoid models developed using IP-protected Hubrecht Organoid Technology (HUB) protocols, as well as HUB’s biobank of already established patient-derived organoids (PDOs)

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  • Large-scale screens and drug radiation: Select models, and evaluate efficacy and multi-drug combination strategies

  • Efficacy and viability quantification: Identify responder and non-responder tumor models. Leverage high content services to produce highly comprehensive morphology readouts in both 2D and 3D models. Use multifactorial data for downstream lead ID and decision-making

  • HCI-based phenotype screening: Phenotypical screen up to thousands of compounds. Layer and score drug effects with image mediated screens

  • Immunotherapy assessment: Benefit from the only immuno- oncology platform incorporating patient-relevant 3D in vitro models co-cultured with non-autologous immune cells

  • OrganoidXplore: The first large-scale, panel based organoid screening service



Simplify your model selection with collated mutational and gene expression profiles for tumor organoid models with this searchable organoid biobank database of PDX-derived organoid (PDXO) tumor models and patient-derived organoids (PDO) organoid models

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High Content Services


Get deeper insights with a suite of powerful 3D in vitro imaging-based assays that recapitulate and quantify complex human biology in a robust and high-throughput imaging platform. Follow up with assisted high content analysis study options.




Expand into immunotherapeutic assessment using the only immuno-oncology platform incorporating patient-relevant 3D in vitro models co-cultured with non-autologous immune cells

60005 - Hub Organoid - Immune Cell Co Culture - RGB - Digital -LIGHT BG - FINAL AW


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