HuGEMM™ Human
CTLA-4 Knock-In Model

Evaluate human specific biological therapies in vivo with humanized drug target mouse models


The HuGEMM humanized CTLA-4 mouse provides a translational model for testing your human specific anti-CTLA-4 agents. This chimeric model has humanized CTLA-4 receptors and a functional mouse immune system.

The CTLA-4 model was developed by replacing mouse exons 2 and 3 with their human counterparts, while murine exons 1 and 4 remain. This allows the in vivo efficacy evaluation of human specific therapeutic antibodies which can recognize the humanized receptor.

  • Evaluate your human specific biological therapies in vivo when no mouse ortholog is available

  • Efficiently study a range of targets for human immunotherapies

  • Save study resources by using a cost effective alternative to more complex fully humanized models

Model Characterization Data

Figure 1: Human CTLA-4 expression on T cells is confirmed by FACS analysis for HuGEMM CTLA-4 knock-in models.

Figure 2: Validation of HuGEMM CTLA-4 with a Yervoy® analog. Tumor growth inhibition of MC38 tumor cells is observed following treatment with anti-hCTLA-4.