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Crown Bioscience Launches MuScreen Platform for Evaluating In Vivo Efficacy of Immuno-oncology Agents

Santa Clara, Calif., April 26, 2016 (PR Newswire)Crown Bioscience, a wholly owned subsidiary of Crown Bioscience International (TWSE: ticker 6554) and a global drug discovery and development solutions company providing translational platforms to advance oncology and metabolic disease research, has announced the launch of MuScreenTM, a new immuno-oncology (IO) service platform utilizing Crown Bioscience’s unique fully characterized syngeneic models.

MuScreen will be offered as a streamlined service for in vivo pharmacodynamic (PD) and efficacy testing using up to 20 syngeneic models. Tissue microarrays can be run in parallel to the in vivo study for high throughput molecular analysis of multiple syngeneic treatment naïve tumor samples. MuScreen enables users to quickly identify the correct model and relevant PD effect for immuno-oncology agents. It is particularly relevant for testing combination strategies, allowing next stage decisions to be made rapidly and efficiently.

“As a leading oncology preclinical solutions provider, our ultimate goal is to deliver superior data in a well-organized and cost-effective manner,” said Qian Shi, vice president of cancer pharmacology and in vitro cancer biology at Crown Bioscience. “By pooling our agents together in a single run, we can dramatically reduce model usage andresource requirements, thus accelerating the process while optimizing its productivity.”

By running MuScreen on a large scale, Crown Bioscience is confident that the quality of PD data will improve, providing an even more complete dataset for both pharmacodynamics and efficacy studies.

Joining Crown Bioscience's broad range of models, including the world’s largest commercial portfolio of PDX models, the launch of MuScreen is testament to Crown Bioscience's continued commitment to providing industry-leading service for global drug discovery.

The platform will become operative the first week of May. Compounds will be enrolled into the screen on a first come, first served basis until 10 group studies have been reached. Additional orders will be given priority for enrollment into the following screening round.

For more information about MuScreen and Crown Bioscience's commitment to improving clinical outcomes, email us at busdev@crownbio.com

About Crown Bioscience Inc.

Crown Bioscience is a global drug discovery and development solutions company providing translational platforms to advance oncology and metabolic disease research. With an extensive portfolio of relevant models and predictive tools, Crown Bioscience enables clients to deliver superior clinical candidates. For more information, please visitwww.crownbio.com.

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