AACR 2022 Posters

615	Tim-3 as an Immune Therapy Target, Mechanism and Action, and Prognostic Values with its Ligands in Patient Stratification Session Category: Immunology -Immune Checkpoints Authors: Jia Xue, Yu Zhang, Xianfei He, Henry Q. Li, Sheng Guo	Read Poster
615A	HuGEMM^TM Modelling Toxicology of Species-Specific Immune Checkpoint Inhibitors Session Category: Immunology -Immune Checkpoints Authors: Tina Zhang, Daniel X. He, Cunxiang Ju, Mingkun Zhang, Jessie JJ. Wang, Likun Zhang, Annie An and Henry Q.X. Li	Read Poster
617	MEK Inhibitor Rescued the Efficacy of PD-1 Blocker in STK11/LKB1 Mutated Colorectal Cancer Model Session Category: Immunology -Immune Response to Therapies 2 / Immune Monitoring and Clinical Correlates Authors: Demi X. Liu, Jun Zhou, Chenpan Nie, Annie An, Henry Q.X. Li, Jessie J.J. Wang	Read Poster

1660	Comparison Between Surgical and Ultrasound-Guided Orthotopic Implantation of Hepatocellular Carcinoma Models in Mice Using Ultrasound and Bioluminescence Imaging Session Category: Tumor Biology - Humanized Mouse Models, Imaging, and Immuno-Oncology Authors: Chris Payne, Yasmin Amer, Ruth Storer, Ganisha Hutchinson, Lucy Harris, Amanda Miles, Yinfei Yin	Read Poster
2059	Immunotherapy Testing in 3D Ex Vivo Patient Tissue Platform with Preserved Tumor Microenvironment Session Category: Immunology -Immune Response to Therapies 1 Authors: Nataliia Beztsinna, Fanny Grillet, Niels Meesters, Donny van der Meer, Lidia Daszkiewicz, Kuan Yan, Emma Spanjaard, Willemijn Vader and Leo Price	Read Poster

2743	Tumor Growth Modeling and its Applications in Preclinical Pharmacology Studies to Improve Translatability of Animal Models Session Category: Bioinformatics / Convergence Science / Systems Biology - Mathematical Models Authors: Huajun Zhou, Binchen Mao, Sheng Guo	Read Poster
3110	Identification of the Phosphorylation Network in PDX and Corresponding Organoid (PDXO) Models Upon Targeted Therapy Treatment Using Deep Phosphoproteomic Analysis Session Category: Tumor Biology - Patient-Derived Xenografts Authors: Xiaoxi Xu, Yuehan Feng, Limei Shang, Leilei Chen, Jessie Wang, Ludovic Bourré, Henry Li	Read Poster
3115	Establishment and Characterization of Patient-Derived Breast Cancer Models for Cancer Studies Session Category: Tumor Biology - Patient-Derived Xenografts Authors: Leilei Chen, Xueying Yang, Lilkun Zhang, Xiaobo Chen, Henry Q.X. Li, Jessie J.J.Wang	Read Poster
3371	Impact of RNA Degradation on Transcriptomic Profiling in Tumor Samples from Syngeneic Mouse Models Session Category: Bioinformatics / Convergence Science / Systems Biology - Application of Bioinformatics to Cancer Biology 2 Authors: Yanghui Sheng, Wubin Qian, Xiaobo Chen, Henry Q. Li, Sheng Guo	Read Poster
3541	A Method to Visualize and Quantify Effects of Immunotherapies in a Physiologically Relevant 3D TME Model Session Category: Immunology -Modifiers of the Tumor Microenvironment Authors: Gera Goverse, Lidia Daszkiewicz, Nataliia Beztsinna, Saskia de Man, Tomas Veenendaal, Michelle Klop, Daniel Okkes, Ashgard Weterings, Kuan Yan, Leo Price	Read Poster

4221	Characterization of OVA-Expressing Immunogenic Syngeneic Tumor Models for Immune Checkpoint Inhibitor Evaluation Session Category: Immunology -Immunomodulatory Agents and Interventions 3 Authors: Chenpan Nie, Yi Zhang, Jia Zheng, Annie An, Jun Zhou, Henry Q.X. Li, Jessie J.J.Wang	Read Poster
4240	In Vivo Assessment of AICD and Cytokine Release Upon Treatment of OKT3 and CD3 Bispecific Antibody in Homozygous CD3EDG HuGEMM™ Session Category: Immunology -Immunomodulatory Agents and Interventions 3 Authors: Daniel X. He, Jie Lin, Wenwei Wang, Cuicui Duo, Lei Zheng, Annie X. An, Henry Q.X. Li	Read Poster

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