Breast cancer is the leading type of cancer diagnosed in women worldwide and requires predictive research models during the preclinical phase of drug development. More
Patient-derived xenograft (PDX) models provide a true representation of human heterogeneity and can be used to test the efficacy of novel compounds against drug resistance.
Our breast cancer PDX models offer the most translational preclinical models for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, patient-derived xenografts reflect the heterogeneity and diversity of the human patient population. PDX models give you an accurate, predictive model of how your compound will perform before entering clinical trials. Crown Bioscience’s breast cancer PDX model collection, known as HuPrime®, is well characterized for pathology, growth characteristics, and are also genetically and genomically annotated for gene expression, gene copy number, mutations, and fusions.
Explore our new breast cancer PDX models, which include pretreated and/or metastatic breast tumors that exhibit therapy resistance, and models with clinically relevant mutations in BRCA1 and ESR1 genes.
MODEL NUMBER | CANCER TYPE | CANCER SUBTYPE | DESCRIPTION | # per page |
---|---|---|---|---|
BR9456 | Breast Cancer | NA | NA | CLICK TO VIEW |
BR9457 | Breast Cancer | TNBC | N/A | CLICK TO VIEW |
BR9462 | Breast Cancer | ER(+), PR(+) | CLICK TO VIEW | |
BR9464 | Breast Cancer | TNBC | N/A | CLICK TO VIEW |
BR9465 | Breast Cancer | TNBC | N/A | CLICK TO VIEW |
BR9466 | Breast Cancer | ER(+) | N/A | CLICK TO VIEW |
BR9469 | Breast Cancer | HER2(-), ER(3+), PR(3+) | CLICK TO VIEW | |
BR9479 | Breast Cancer | TNBC | CLICK TO VIEW | |
BR9480 | Breast Cancer | TNBC | CLICK TO VIEW | |
BR9493 | Breast Cancer | N/A | N/A | CLICK TO VIEW |
BR9494 | Breast Cancer | N/A | N/A | CLICK TO VIEW |
Our breast cancer PDX collection consists of a wide range of models, including triple negative breast cancer (TNBC) models as well as ER+, PR+, and HER2+ models. Breast cancer organoids are also available to complement our PDX in vivo collection.
MODEL NUMBER | CANCER TYPE | CANCER SUBTYPE | DESCRIPTION | # per page |
---|---|---|---|---|
BR0438 | Breast Cancer | HER2 (1+ or 2+), ER (-), PR (-) | Invasive ductal carcinoma of right breast, grade II,no tumor embolus in vessel. Regional LN: the first group of the first level LN (0/6), the second group of the first level LN (0/7), the second lelel LN (0/5), intermuscular LN (0/1). | CLICK TO VIEW |
BR10014 | Breast Cancer | TNBC | Breast Carcinoma. Metastatic ductal carcinoma. | CLICK TO VIEW |
BR10508 | Breast Cancer | NA | Breast Carcinoma | CLICK TO VIEW |
BR10539 | Breast Cancer | TNBC | Breast Carcinoma | CLICK TO VIEW |
BR10562 | Breast Cancer | HER2 (+) | Breast Carcinoma | CLICK TO VIEW |
BR10583 | Breast Cancer | NA | Breast carcinoma | CLICK TO VIEW |
BR10607 | Breast Cancer | NA | Breast Carcinoma | CLICK TO VIEW |
BR1115 | Breast Cancer | HER2 (0.5+), ER (+), PR (+) | Invasive carcinoma of right breast. | CLICK TO VIEW |
BR1282 | Breast Cancer | TNBC | Invasive ductal carcinoma of right breast, tumor mass: 3 x 3 x 2cm. The tumor forms solid structures and has an infiltrative growth pattern. Tumor cells show cirlular and atypia. Necrosis and squamous metaplasia may be seen in cancer nest. Regional LN: axillary LN (0/19). | CLICK TO VIEW |
BR1283 | Breast Cancer | TPBC | Invasive ductal carcinoma of right breast | CLICK TO VIEW |
BR1458 | Breast Cancer | TNBC | Invasive ductal carcinoma of left breast (moderately differentiated, score: 7) | CLICK TO VIEW |
BR1467 | Breast Cancer | Adenocarcinoma | N/A | CLICK TO VIEW |
BR1474 | Breast Cancer | TNBC | Invasive ductalpapillary carcinoma of left breast. The tumor forms papillary structures and has an infiltrative growth pattern. Regional LN: axillary LN (1/21). | CLICK TO VIEW |
BR2014 | Breast Cancer | TNBC | NA for clinical diagnosis info. Pathology QC on PDX: Invasive ductal carcinoma. | CLICK TO VIEW |
BR2397 | Breast Cancer | N/A | N/A | CLICK TO VIEW |
BR2401 | Breast Cancer | N/A | N/A | CLICK TO VIEW |
BR2543 | Breast Cancer | NA | breast cancer | CLICK TO VIEW |
BR3058 | Breast Cancer | NA | Invasive ductal carcinoma of right breast, grade II-III. The tumor forms nest or sheet structures with metastatic spread to right axillary | CLICK TO VIEW |
BR3116 | Breast Cancer | TNBC | Metastatic invasive ductal carcinoma of breast to left pectoralis major and anterior chest wall on basis of medical history. | CLICK TO VIEW |
BR3267 | Breast Cancer | ER (+) | invasive ductal carcinoma, grade II | CLICK TO VIEW |
BR5009 | Breast Cancer | HER2 (+) | breast cancer. Pathol comment: no definite tumor cells present in cell block. rare possible tumor cells present in cytospin prep. | CLICK TO VIEW |
BR5010 | Breast Cancer | TNBC | breast carcinoma, invasive ductal carcinoma, grade III. Pathol comment: c/w diagnosis. approximately 90% of the tissue involved by malignant tumor in sections examined. malignant tumor cells present in cytospin prep. | CLICK TO VIEW |
BR5011 | Breast Cancer | TNBC | breast carcinoma. Pathol comment: c/w referring diagnosis. malignant tumor cells present in cell block and cytospin prep. | CLICK TO VIEW |
BR5012 | Breast Cancer | ER (+) | breast carcinoma. Pathol comment: c/w referring diagnosis. malignant tumor cells present in cell block and cytospin prep. | CLICK TO VIEW |
BR5013 | Breast Cancer | TNBC | breast carcinomainfiltrating ductal carcinoma. Pathol comment: no definite malignant tumor present in sections examined. malignant tumor cells present in cytospin prep, c/w referring diagnosis. | CLICK TO VIEW |
BR5017 | Breast Cancer | TNBC | breast carcinoma c/w carcinoma, pd. Pathol comment: c/w referring diagnosis. malignant tumor cells present in cell block section and cytospin prep. | CLICK TO VIEW |
BR5022 | Breast Cancer | ER (+), PR (+) | breast carcinoma | CLICK TO VIEW |
BR5337 | Breast Cancer | TNBC | Breast Carcinoma. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 60% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. | CLICK TO VIEW |
BR5380 | Breast Cancer | NA | Breast Carcinoma. Pathol comment: C/W REFERRING DIAGNOSIS. MALIGNANT TUMOR CELLS PRESENT IN CELL BLOCK SECTION AND CYTOSPIN PREP. | CLICK TO VIEW |
BR5399 | Breast Cancer | TNBC | Breast Cancer; Triple Negative | CLICK TO VIEW |
BR5400 | Breast Cancer | NA | NA for clinical diagnosis info. | CLICK TO VIEW |
BR5484 | Breast Cancer | IDC | Breast Carcinoma. Pathol comment: C/W REFERRING DIAGNOSIS. TUMOR CELLS PRESENT IN CELL BLOCK AND CYTOSPIN PREP. | CLICK TO VIEW |
BR5494 | Breast Cancer | NA | Breast Carcinoma. Pathol comment: C/W REFERRING DIAGNOSIS. MALIGNANT TUMOR CELLS PRESENT IN CELL BLOCK SECTION AND CYTOSPIN PREP. | CLICK TO VIEW |
BR5496 | Breast Cancer | ER (+) | Breast Carcinoma. Pathol comment: C/W DIAGNOSIS. APPROX. 40% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. 60% NECROTIC. MALIGNANT TUMOR CELLS IN CYTOSPIN PREP. | CLICK TO VIEW |
BR6695 | Breast Cancer | Sarcomatoid | Malignant spindle cell carcinoma. | CLICK TO VIEW |
BR6698 | Breast Cancer | Adenocarcinoma | NA | CLICK TO VIEW |
BR6703 | Breast Cancer | NA | NA | CLICK TO VIEW |
BR9230 | Breast Cancer | N/A | N/A | CLICK TO VIEW |
BR9234 | Breast Cancer | N/A | N/A | CLICK TO VIEW |
BR9236 | Breast Cancer | NA | NA | CLICK TO VIEW |
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