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Patient-Derived Xenograft Models of Breast Cancer

Breast cancer is the leading type of cancer diagnosed in women worldwide and requires predictive research models during the preclinical phase of drug development. More

Patient-derived xenograft (PDX) models provide a true representation of human heterogeneity and can be used to test the efficacy of novel compounds against drug resistance.

Benefits of Our Breast Cancer PDX Models

Our breast cancer PDX models offer the most translational preclinical models for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, patient-derived xenografts reflect the heterogeneity and diversity of the human patient population. PDX models give you an accurate, predictive model of how your compound will perform before entering clinical trials. Crown Bioscience’s breast cancer PDX model collection, known as HuPrime®, is well characterized for pathology, growth characteristics, and are also genetically and genomically annotated for gene expression, gene copy number, mutations, and fusions.

Breast Cancer Models of Resistance and Metastasis

Explore our new breast cancer PDX models, which include pretreated and/or metastatic breast tumors that exhibit therapy resistance, and models with clinically relevant mutations in BRCA1 and ESR1 genes.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
BR9456 Breast Cancer NA NA CLICK TO VIEW
BR9457 Breast Cancer TNBC N/A CLICK TO VIEW
BR9462 Breast Cancer ER(+), PR(+)  CLICK TO VIEW
BR9464 Breast Cancer TNBC N/A CLICK TO VIEW
BR9465 Breast Cancer TNBC N/A CLICK TO VIEW
BR9466 Breast Cancer ER(+) N/A CLICK TO VIEW
BR9469 Breast Cancer HER2(-), ER(3+), PR(3+)  CLICK TO VIEW
BR9479 Breast Cancer TNBC  CLICK TO VIEW
BR9480 Breast Cancer TNBC CLICK TO VIEW
BR9493 Breast Cancer N/A N/A CLICK TO VIEW
BR9494 Breast Cancer N/A N/A CLICK TO VIEW

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Additional Breast Cancer Models

Our breast cancer PDX collection consists of a wide range of models, including triple negative breast cancer (TNBC) models as well as ER+, PR+, and HER2+ models. Breast cancer organoids are also available to complement our PDX in vivo collection.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
BR0438 Breast Cancer HER2 (1+ or 2+), ER (-), PR (-) Invasive ductal carcinoma of right breast, grade II,no tumor embolus in vessel. Regional LN: the first group of the first level LN (0/6), the second group of the first level LN (0/7), the second lelel LN (0/5), intermuscular LN (0/1). CLICK TO VIEW
BR10014 Breast Cancer TNBC Breast Carcinoma. Metastatic ductal carcinoma. CLICK TO VIEW
BR10508 Breast Cancer NA Breast Carcinoma CLICK TO VIEW
BR10539 Breast Cancer TNBC Breast Carcinoma CLICK TO VIEW
BR10562 Breast Cancer HER2 (+) Breast Carcinoma CLICK TO VIEW
BR10583 Breast Cancer NA Breast carcinoma CLICK TO VIEW
BR10607 Breast Cancer NA Breast Carcinoma CLICK TO VIEW
BR1115 Breast Cancer HER2 (0.5+), ER (+), PR (+) Invasive carcinoma of right breast. CLICK TO VIEW
BR1282 Breast Cancer TNBC Invasive ductal carcinoma of right breast, tumor mass: 3 x 3 x 2cm. The tumor forms solid structures and has an infiltrative growth pattern. Tumor cells show cirlular and atypia. Necrosis and squamous metaplasia may be seen in cancer nest. Regional LN: axillary LN (0/19). CLICK TO VIEW
BR1283 Breast Cancer TPBC Invasive ductal carcinoma of right breast CLICK TO VIEW
BR1458 Breast Cancer TNBC Invasive ductal carcinoma of left breast (moderately differentiated, score: 7) CLICK TO VIEW
BR1467 Breast Cancer Adenocarcinoma N/A CLICK TO VIEW
BR1474 Breast Cancer TNBC Invasive ductalpapillary carcinoma of left breast. The tumor forms papillary structures and has an infiltrative growth pattern. Regional LN: axillary LN (1/21). CLICK TO VIEW
BR2014 Breast Cancer TNBC NA for clinical diagnosis info. Pathology QC on PDX: Invasive ductal carcinoma. CLICK TO VIEW
BR2397 Breast Cancer N/A N/A CLICK TO VIEW
BR2401 Breast Cancer N/A N/A CLICK TO VIEW
BR2543 Breast Cancer NA breast cancer CLICK TO VIEW
BR3058 Breast Cancer NA Invasive ductal carcinoma of right breast, grade II-III. The tumor forms nest or sheet structures with metastatic spread to right axillary CLICK TO VIEW
BR3116 Breast Cancer TNBC Metastatic invasive ductal carcinoma of breast to left pectoralis major and anterior chest wall on basis of medical history. CLICK TO VIEW
BR3267 Breast Cancer ER (+) invasive ductal carcinoma, grade II CLICK TO VIEW
BR5009 Breast Cancer HER2 (+) breast cancer. Pathol comment: no definite tumor cells present in cell block. rare possible tumor cells present in cytospin prep. CLICK TO VIEW
BR5010 Breast Cancer TNBC breast carcinoma, invasive ductal carcinoma, grade III. Pathol comment: c/w diagnosis. approximately 90% of the tissue involved by malignant tumor in sections examined. malignant tumor cells present in cytospin prep. CLICK TO VIEW
BR5011 Breast Cancer TNBC breast carcinoma. Pathol comment: c/w referring diagnosis. malignant tumor cells present in cell block and cytospin prep. CLICK TO VIEW
BR5012 Breast Cancer ER (+) breast carcinoma. Pathol comment: c/w referring diagnosis. malignant tumor cells present in cell block and cytospin prep. CLICK TO VIEW
BR5013 Breast Cancer TNBC breast carcinomainfiltrating ductal carcinoma. Pathol comment: no definite malignant tumor present in sections examined. malignant tumor cells present in cytospin prep, c/w referring diagnosis. CLICK TO VIEW
BR5017 Breast Cancer TNBC breast carcinoma c/w carcinoma, pd. Pathol comment: c/w referring diagnosis. malignant tumor cells present in cell block section and cytospin prep. CLICK TO VIEW
BR5022 Breast Cancer ER (+), PR (+) breast carcinoma CLICK TO VIEW
BR5337 Breast Cancer TNBC Breast Carcinoma. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 60% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
BR5380 Breast Cancer NA Breast Carcinoma. Pathol comment: C/W REFERRING DIAGNOSIS. MALIGNANT TUMOR CELLS PRESENT IN CELL BLOCK SECTION AND CYTOSPIN PREP. CLICK TO VIEW
BR5399 Breast Cancer TNBC Breast Cancer; Triple Negative CLICK TO VIEW
BR5400 Breast Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
BR5484 Breast Cancer IDC Breast Carcinoma. Pathol comment: C/W REFERRING DIAGNOSIS. TUMOR CELLS PRESENT IN CELL BLOCK AND CYTOSPIN PREP. CLICK TO VIEW
BR5494 Breast Cancer NA Breast Carcinoma. Pathol comment: C/W REFERRING DIAGNOSIS. MALIGNANT TUMOR CELLS PRESENT IN CELL BLOCK SECTION AND CYTOSPIN PREP. CLICK TO VIEW
BR5496 Breast Cancer ER (+) Breast Carcinoma. Pathol comment: C/W DIAGNOSIS. APPROX. 40% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. 60% NECROTIC. MALIGNANT TUMOR CELLS IN CYTOSPIN PREP. CLICK TO VIEW
BR6695 Breast Cancer Sarcomatoid Malignant spindle cell carcinoma. CLICK TO VIEW
BR6698 Breast Cancer Adenocarcinoma NA CLICK TO VIEW
BR6703 Breast Cancer NA NA CLICK TO VIEW
BR9230 Breast Cancer N/A N/A CLICK TO VIEW
BR9234 Breast Cancer N/A N/A CLICK TO VIEW
BR9236 Breast Cancer NA NA CLICK TO VIEW

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