Genomic characterisation of Chinese clear cell renal cell carcinoma revealed novel prognostic differences across populations
Qiang Zhao*, Jia Xue, Wubin Qian, Tiezhu Liu#, Bin Fan, Jie Cai, Yongpeng Ji*, Jia Liu*, Yong Yang*, Qi-Xiang Li, Sheng Guo, and Ning Zhang*
*Beijing Institute for Cancer Research, Department of Urology, Beijing Cancer Hospital, Beijing
#Department of Urology, Daqing Oilfield General Hospital, Heilongjiang, P. R. China
Kidney cancer has been well characterised, with large scale omics collections (e.g. TCGA) released and analysed for hundreds of patients. However, this data is mainly limited to Caucasians.
In this poster, we investigate the genomics of Chinese clear cell renal cell carcinoma (ccRCC) patients. Whole transcriptome sequencing was performed on 55 tumour tissues and 11 matched normal tissues, which were compared with ccRCC TCGA datasets.
The resulting datasets reveal differences between the populations which may have implications for treatment pathways.
Read this Poster to Discover:
- That PBRM1 has a lower mutation frequency in Chinese ccRCC patients compared with Caucasian patients
- The classification of the patient cohort into three classes based on gene expression
- The identification of immune active and tolerant tumours, which may reveal which patient subsets could benefit from immunotherapy