Pirouz Daftarian*, Marybeth George*, Eden Kleiman*, Amy Yamamura, Zhongliang Li, Mingfa Zang, Derron Yu, Eunmi Hwang, Annie X. An, Ann E. Lin, Henry Li, Wushouer Ouerkaxi#
*JSR Life Sciences LLC, Sunnyvale, CA; #MBL International Corporation, Woburn, MA
T cell exhaustion arises when sustained expression of co-inhibitory molecules results in incomplete clearance of antigens. T cell exhaustion is exploited by some cancers, but exhausted T cells may be reversed with the right immune checkpoint blockade, thereby restoring effector T cell function.
Understanding the capacity and expression of co-inhibitory molecules can potentially help in predicting responders for specific immune checkpoint therapies. Screening patient peripheral blood using non-invasive methods could boost the accuracy of selecting the right candidates for clinical immune checkpoint therapy, therefore leading to improved treatment success.
This poster details the optimization and validation of an assay system for the functional screening of immune checkpoint blockades (ICBs) and for the classification of responders versus non-responders to ICBs.