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AACR Poster 1503: Immune Cell Depletion Affects aPD-1 Efficacy

Effect of Immune Cell Depletion on Response to PD-1 Treatment in Syngeneic Models

Ying Jin, Yongli Shan, Chunkai, Li, Annie X. An, Henry Q. Li, Davy X. Ouyang

AACR Poster 1503: Immune Cell Depletion Affects aPD-1 EfficacyWith the continued rise of immunotherapy, it is becoming critically important to fully understand which immune cell lineages play a major role in mediating PD-1 response, in any given tumor microenvironment.

It is already well-known that anti-PD-1 antibodies work via activation of cytotoxic T cells. However, the contribution of other immune cell populations to PD-1 treatment are not well defined.

To understand how different lineages of immune cells impact PD-1 efficacy, we depleted various immune cell subpopulations in MC38, CT-26, and Hepa 1-6 murine syngeneic models when treated with PD-1 antibody, with the initial results presented here.

Read this Poster to Discover:

  • The effectiveness of immune cell depletion for CD4 T cells, CD8 T cells, Treg cells, NK cells, MDSC, and macrophages

  • That depletion of CD8 T cells significantly attenuates anti-PD-1 treatment antitumor effects, confirming the crucial role of CD8 T cells in tumor killing

  • That CD4+ T cell depletion induces contrary effects across the syngeneic models tested

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