AACR-NCI-EORTC Poster C118: Implantation Site Effects on PDX

Transcriptome Comparison of Orthotopic and Subcutaneous Patient-Derived Xenografts

Binchen Mao, Xiaoqian Jiang, Jia Xue, Wubin Qian, Henry Li, Sheng Guo

The location of implanted tumor models can affect stromal interactions (including immune response) and result in different tumor expansion. Despite this, there have been limited studies on gene expression differences in subcutaneous vs orthotopically implanted tumor models.

This poster details preliminary investigations into transcriptome differences between subcutaneous and orthotopic patient-derived xenograft (PDX) models. PDX are commonly used in the subcutaneous setting, but have more relevant organ-specific tumor microenvironment interactions and metastasis potential when implanted orthotopically.

Read this Poster to Discover:

• How implantation site has a pronounced impact on PDX tumor transcriptome across cancer types in preliminary investigations
  
  
• That cancer type and relevant organ-specific TME also influence transcriptome profile and correlation
  
  
• Why further investigation is needed, potentially removing the influence of cancer type by focusing on individual cancers

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