Binchen Mao, Sheng Guo, Bonnie Chen, Davy Ouyang, Henry Q. Li
Patient-derived xenografts (PDX) are a predictive preclinical model for translational oncology research. To maximize their full potential including for biomarker discovery, comprehensive genomic, proteomic, and pathological annotation of baseline and treated PDX models is needed.
This poster presents a comparison of genomic and proteomic profiles for a panel of gastric cancer PDX. These models have previously been used to determine biomarkers predictive of cetuximab response in gastric cancer.
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