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Drug Development With Organoids

Advance oncology research with HUB Organoids.
Our proprietary models deliver reproducibility, standardized assays, and unmatched turnaround time to move your program forward faster.

Make Faster, Smarter Research Decisions

These organoid platform features help you reduce the risk of clinical failure by
generating data that is more predictive, reproducible, and clinically relevant.

Accelerate Results with Assay-Ready Organoids

Turn organoid complexity into speed with assay-ready organoid batches that deliver CTG efficacy data in only 3 weeks.

Find the Right Model with Our Organoid Biobank

Largest commercially available organoid (PDO and PDXO) biobank - with matched in vivo capabilities.

Build Confidence in Your Results

Get fully characterized, QC-verified models and assays designed for consistent, reproducible results. Models and assays are held to the highest industry standards, with high assay reproducibility and PDXO models free of mouse-derived content, reducing uncertainty and helping prevent costly downstream surprises.

Protect Your Samples with Advanced QC

Protect study integrity with a level of genomic quality control not typically available from standard profiling approaches. SNP-based profiling delivers up to 10× greater sensitivity than STR-based profiling, enabling more sensitive detection of contamination and helping ensure the integrity of every biobank sample.

Preserve Patient-Relevant Biology

Trust that results reflect patient biology because our proprietary culture methods, built on exclusive Clevers Lab HUB protocols, preserve clinical fidelity that standard systems lose.

Access 35+ Disease Indications

Across 35+ indications including (patient-matched) normal and primary + metastatic models, and resistant/pre-treated models.

A Look Inside Crown’s Organoid Platform

Platform Applications

Drug Discovery and Development
Drug Discovery and Development

Test candidate efficacy, safety, side effects, and pharmacokinetic properties as well as mechanism of action.

Safety and Toxicity Studies
Safety and Toxicity Studies

Evaluate safety and toxicity profiles using healthy organoids developed from non transformed cells.

Disease Modeling
Disease Modeling

Capture disease relevance and patient population heterogeneity with disease modeling, including models of drug resistance.

Bridging In Vitro and In Vivo
Bridging In Vitro and In Vivo

Identify your target patient population before entering the clinical trials.

Predictive Biomarker Identification
Predictive Biomarker Identification

Determine potential biomarkers of therapeutic response with companion diagnostics.

Improve Predictivity With Organoid Models
Improve Predictivity With Organoid Models

Access Crown Bioscience’s database of patient-relevant PDX-derived organoids (PDXO) with matched PDX data. Search histopathology, IC50, genomic, and transcriptomic profiles to select the most predictive models for your studies.

Study Options

Large-Scale Screens and Drug Radiation
Large-Scale Screens and Drug Radiation

Select models and evaluate efficacy and multi-drug combination strategies.

Efficacy and Viability Quantification
Efficacy and Viability Quantification

Identify responder and non-responder tumor models. Leverage high content services to produce highly comprehensive morphology readouts in both 2D and 3D models. Use multifactorial data for downstream lead ID and decision-making.

HCI-Based Phenotype Screening
HCI-Based Phenotype Screening

Phenotypically screen up to thousands of compounds. Layer and score drug effects with image mediated screens.

Immunotherapy Assessment
Immunotherapy Assessment

Benefit from the only immuno-oncology platform incorporating patient-relevant 3D in vitro models co-cultured with non-autologous immune cells.

organoidxplore
OrganoidXplore

Take advantage of the first large-scale, panel-based organoid screening service.

Frequently Asked Questions

What makes HUB Organoids unique?

HUB Organoids are created using Clevers Lab protocols through exclusive partnerships to ensure high fidelity, reproducibility, and proprietary culture methods for oncology drug development.

How do matched models improve predictivity?

We offer paired in vitro PDXO and in vivo PDX models, allowing for a seamless transition between study phases and improved translational predictivity.

What is the living biobank?

Our searchable organoid database contains genomic, transcriptomic, and pharmacology data to streamline model selection.

Can I test both tumor and healthy tissue organoids?

Yes. Our biobank includes both tumor organoids and healthy organoids from non-transformed cells, enabling safety and toxicity profiling alongside efficacy testing.

Can organoids predict patient response better than animal models?

Organoids derived from patient tumors often provide higher translational predictivity for certain therapeutic classes because they retain the genetic and phenotypic characteristics of the original tumor.

Do you offer custom organoid model development?

Yes. We can establish new patient-derived organoids from your own samples or collect fresh tumor material through our network of partners, subject to ethical approvals.

Discuss Your Target ID and Validation Project

From in vitro and in vivo models to in silico insights, genomics, proteomics, and exclusive biobank resources, we deliver the integrated solutions you need to discover, validate, and advance the next generation of therapies. Contact us today to accelerate your breakthroughs.