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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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On Demand Webinar

3 Strategies to Identify Clinically Predictive Biomarkers in the Preclinical Space

Identifying Clinically Predictive Biomarkers in the Preclinical Space

Robust and sensitive biomarker discovery and validation is key to identifying the right patient populations and cancer indications for specific therapeutics. This, in turn, is vital to progressing personalized medicine approaches to improve anticancer agent attrition rates and patient outcomes.

Early identification of biomarkers during preclinical drug development provides extra benefits including facilitating biomarker and companion diagnostic clinical testing, and ultimately de-risking clinical trials.

In this webinar, we review how to apply systems biology in early stage drug development for biomarker discovery and validation, and how to translate preclinical biomarkers to the clinic to improve trial outcomes. We also present three case studies showing novel strategies to identify and utilize biomarkers using a range of translational preclinical models.

Watch this Webinar to Learn How To:

  • Funnel your therapeutic through in silico, in vitro, ex vivo, and in vivo model systems in an intelligent way, reducing timelines and maximizing data value
  • Use in vitro models to uncover genetic signatures of response and guide in vivo model selection for further validation
  • Explore drug mechanism of action using patient-derived xenografts (PDX) enabling clinical-preclinical data corroboration
  • Translate preclinical biomarkers into the clinic, and how this enables the identification and stratification of relevant patient populations

Who Should Watch:

  • Oncology program leaders who want to maximize their therapeutic candidate's clinical benefit through improved patient stratification
  • Scientists interested in optimizing preclinical studies including mouse clinical trials for biomarker discovery
  • Decision makers looking to achieve efficient and rapid market approval of oncology agents

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About The Presenter:

Mike Batey, Crown Bioscience Inc webinarMike Batey has over 20 years’ experience in preclinical and translational science, business development, and marketing, across a variety of academic, industrial, and commercial roles. His major focus has been in cancer research and small animal imaging and he has authored more than 30 abstracts and publications.

Mike started his career at the Northern Institute for Cancer Research, Newcastle University, UK, (1997-2011) where he developed expertise in the design and establishment of new models of cancer (including primary, human derived models, and orthotopic models in both solid and liquid disease). Mike also made key contributions to the development of a number of novel anticancer drugs now licensed or in late stage clinical trial, including preclinical biomarker discovery.

Prior to joining Crown Bioscience, Mike worked as an independent consultant to Pharma and Biotech. His previous roles include Head of Oncology and Preclinical Imaging at Epistem Ltd. (2011-2016), and Senior Business Development Manager, Global Marketing at Waters Corporation (2016-2018). Mike is an active member of the American Association for Cancer Research.



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