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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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On Demand Webinar

Efficacy and irAE Assessment Of Therapeutic Antibodies With Target Specific Knock-In Models

imagePresenter: Dr Hongjuan Zhang, Senior Scientist, Cancer Biology and Immunology

The preclinical development of human-specific immunotherapeutics is currently hampered by a lack of in vivo immunotherapy models for efficacy testing that feature human targets in the presence of a functional immune system. There's also a need to study unique immune-related adverse events (irAEs), caused by I/O agents potentiating tumor-reactive immune responses, leading to on/off target non-specific immune attack.

In this webinar, Dr Hongjuan Zhang explores novel HuGEMM™ and HuCELL™ platforms for assessing human-specific immunotherapies. These models feature humanized drug targets replacing their murine counterpart on host T cells or tumor cells and within a fully functional murine immune system. Hongjuan also presents the latest research applying these platforms to assessing immune related toxicities, to accelerate immuno-oncology drug discovery programs.

Watch this Webinar to Explore:

  • How to use human knock-in models to study clinically-observed immune toxicities related to preclinical I/O drug development
  • The evaluation of urelumab efficacy and liver toxicity using the CD137 HuGEMM model and a chimeric mIgG1 version of the compound
  • The assessment of a human CD40 agonist to study efficacy and both in vitro- and in vivo-mediated immune toxicity using the CD40 HuGEMM model
  • How to use a PD-1/CTLA-4 double knock-in HuGEMM model to mimic clinically observed irAEs, and how to accelerate a new candidate’s safety assessment by de-risking irAEs
  • The effects of CD47 immune checkpoint inhibitors on efficacy and erythrocyte toxicity

Who Should Watch:

  • Oncology researchers studying immune checkpoint inhibitors with related in vivo toxicities
  • Scientists interested in learning how in vivo models are used to evaluate human-specific therapies for both efficacy and toxicity within the same animal model
  • Researchers looking to understand how human knock-in model systems are used to interrogate I/O drug mechanism of action and related toxicity

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About The Presenter:

Hongjuan Zhang, PhD, Senior ScientistHongjuan Zhang, PhD, Senior Scientist, Cancer Biology and Immunology focuses on in vitro and in vivo immuno-oncology assay development. Dr Zhang received her PhD from the School of Life Science at Tsinghua University, Beijing. She performed her postdoctoral training at the National Institute of Biological Science (NIBS, Beijing), where she studied the tumorigenesis of lung cancer using genetically engineered mouse models. Hongjuan also trained as a postdoctoral research fellow in the Department of Surgery, University of Michigan, studying the role epigenetic modifiers in regulating T cell activation in the context of tumor immunology.

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