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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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On Demand Webinar

Applications of HUB Tumor Organoids in Oncology Drug Discovery

Applications of Tumor Organoids in Oncology Drug DiscoveryPresenter: Dr Rajendra Kumari,
Global Head of Scientific Communications

Tumor organoids offer an innovative and predictive in vitro platform to revolutionize oncology drug development. Derived from cancer stem cells, organoids provide a unique 3D in vitro system recapitulating the histo- and molecular pathology of their corresponding in vivo tumor.

Organoids are generated following protocols established by Hubrecht Organoid Technology (HUB) from both patient tumors as well as PDX models, offering the flexibility to rapidly establish large libraries of PDX-derived organoids with paired in vivo models. These libraries present multiple drug development opportunities, including large scale single agent and combination regimen screening.

In this webinar Dr Rajendra Kumari details many applications of tumor organoids in oncology drug discovery. She also explores how to use matched organoid/PDX models in a unique and predictive paired in vitro/in vivo platform to improve translation of preclinical data into clinical success.

Watch this Webinar to Learn:

  • How to apply tumor organoids to large scale drug screening, in vivo model selection, and in silico drug discovery
  • How to successfully predict patient response using organoids
  • How organoids represent a superior and innovative in vitro system to disrupt traditional oncology drug discovery
  • The “biological equivalence” between patient-derived and PDX-derived organoids
  • How to accelerate drug development using our unique matched in vitro PDX-derived organoid (PDXO)/in vivo PDX pairs for improved predictivity

Who Should Watch:

  • Decision makers from biotech and pharmaceutical companies who want to understand how to enhance oncology drug discovery programs through organoid applications
  • Drug developers who are looking for relevant in vitro models with matched in vivo models for optimal predictivity
  • Scientists interested in using in vitro models that recapitulate a human organ’s function in vivo

Watch Now!


About The Presenter:

Dr Rajendra KumariDr Rajendra Kumari is the Global Head of Scientific Communications for Crown Bioscience, providing scientific guidance and communications on company products, services, and R&D.

Rajendra received her PhD from the University of Leicester in Molecular Pharmacology, following which she joined the lab of Prof. Sue Watson as a postdoctoral fellow in the Division of Pre-clinical Oncology, School of Clinical Sciences, University of Nottingham (UoN). In 2005, Rajendra took the role of Project and Business Manager of the Preclinical Oncology Services (PRECOS) contract research business unit where she built up and managed the portfolio of preclinical in vitro and in vivo projects, products, team and clients, as well as marketing and developing the commercial processes of PRECOS.

Rajendra’s expertise in cancer cell biology and model development helped to build PRECOS, develop an academic career as a lecturer in the School of Clinical Sciences, as well as co-founding the Ex Vivo Pharmacology Centre of Excellence (UoN), which recapitulates the tumor microenvironment through use of clinically-derived tissue. Rajendra was pivotal in the growth of the business unit and commercialization of research which led to the establishment of the spinout of PRECOS Ltd in 2010, acting as Chief Operations Officer, Board Director and co-founder, until merger with CrownBio in July 2013 where she then acted as GM/CSO for CrownBio UK for 4 years.

Rajendra is a member of the American Association of Cancer Research, British Association of Cancer Research, the NC3Rs Cancer Research Advisory Group, and has authored over 40 abstracts and publications.



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