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Model Information:

This strain carries a conditional mutant Kras (KrasLSL-G12D/WT) and a conditional knock out of PTEN (PTENflox/flox). G12D mutant Kras was activated and PTEN was knocked out upon administrating the adeno-cre virus to the bladder at 6 weeks of age, which resulted in a tumor in the bladder approximately 4 months later.
Cancer Type Bladder Cancer
Mutations KRAS (G12D); PtenFlox/Flox
Biopsy Site Bladder (near the suture)
Pathology QC Synovial sarcoma (Pa)
Mouse Strain C57BL/6

Growth Characteristics

Additional Characteristics

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