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AACR 2023 Posters

29

Characterization of a Murine Intestinal Cancer Homograft Model for Therapeutic Evaluation

Session Date and Time:
Sunday Apr 16, 2023 
1:30 PM - 5:00 PM 

Session Category: Tumor Biology
Authors: Jinxi Wang, Leilei Chen, Likun Zhang, Jingqian Zhu, Ludovic Bourre, Jessie J.J. Wang

52

Characterization of Murine Intrahepatic Cholangiocarcinoma Homograft Models for Therapeutic Evaluation

Session Date and Time:
Sunday Apr 16, 2023 
1:30 PM - 5:00 PM 

Session Category: Tumor Biology
Authors: Jinxi Wang, Leilei Chen, Likun Zhang, Lei Zheng, Ludovic Bourre, Jessie J.J. Wang

185

Global Mapping of Pathway Modules and Phosphorylation Networks in PDX and Corresponding Organoid (PDXO) Models Treated with Targeted Therapies

Session Date and Time:
Sunday Apr 16, 2023 
1:30 PM - 5:00 PM 

Session Category: Tumor Biology
Authors: Martin Mehnert, Xiaoxi Xu, Tobias Treiber, Limei Shang, Leilei Chen, Jessie Wang, Marco Tognetti, Christopher Below, Roland Bruderer, Jakob Vowinckel, Binchen Mao, Wubin Qian, Sheng Guo, Ludovic Bourré, Yuehan Feng

198

Pan-cancer Assay-ready Organoid Drug Screening with Robust, Reproducible and Clinically-relevant Output 

Session Date and Time:
Sunday Apr 16, 2023 
1:30 PM - 5:00 PM 

Session Category: Tumor Biology
Authors: Liza Wijler, Jara Garcia Mateos, My Nguyen, Annelot Staes, Linda van Seters, Lama Hasan, Victor Tirouille, Bram Herpers, Leo Price, Mariusz Madej, Michiel Fokkelman, Marrit Putker

401

Developing KRAS G12C Inhibitor-resistant Tumor Models for Efficacy Evaluation of Next-generation Anticancer Therapies 

Session Date and Time:
Sunday Apr 16, 2023 
1:30 PM - 5:00 PM 

Session Category: Experimental and Molecular Therapeutics
Authors: Jun Zhou, Zi Ye, Dan Zhang, Aaron Hua, Chenpan Nie, Jessie (Jingjing) Wang, Rajendra Kumari, Leo Price, Xiaoxi Xu

497

HX301, a First-in-class ARK5i, Demonstrates Antitumor Activity in Preclinical HCC Models with High ARK5/Myc Expression

Session Date and Time:
Sunday Apr 16, 2023 
1:30 PM - 5:00 PM 

Session Category: Experimental and Molecular Therapeutics
Authors: Zhihua Jiao, Jessie Wang, Hang Ke, Faming Zhang, and Henry Li

579

Mini-tumors: Preclinical HCI Assays to Screen Anti-cancer Drugs in the Context of Organoids, Cancer-associated Fibroblasts and Immune Cells 

Session Date and Time:
Sunday Apr 16, 2023 
1:30 PM - 5:00 PM 

Session Category: Experimental and Molecular Therapeutics
Authors: Marten Hornsveld, Guusje Odenkirchen, Cyrelle van Dort, Jara Garcia, Saskia de Man, Gera Goverse, Bram Herpers, Mariusz Madej, Leo Price, Marrit Putker

2053

Structural Variants Detected by Optical Genome Mapping in Acute Lymphoblastic Leukemia Patient-Derived Xenograft Models

Session Date and Time:
Monday Apr 17, 2023 
9:00 AM - 12:30 PM 

Session Category: Bioinformatics / Computational Biology / Systems Biology / Convergent Science
Authors: Yueying Wang, Mengting Qing, Jinping Liu, Xiaobo Chen, Jia Xue, Sheng Guo

2387

Characterization of Orthotopic Bioluminescent Patient-derived Xenografts Model of Glioma for Drug Discovery

Session Date and Time:
Monday Apr 17, 2023 
1:30 PM - 5:00 PM 

Session Category: Tumor Biology
Authors: Jinxi Wang, Ling Chen, Jun Zhou, Likun Zhang, Jinyu Huang, Xueluan Zhu, Ludovic Bourre, Jessie J.J. Wang

2822

Maximizing Radiotherapy Impact: A Novel Preclinical Platform for Screening of Radiosensitizing Agents in Patient-derived Tumor Organoids

Session Date and Time:
Monday Apr 17, 2023 
1:30 PM - 5:00 PM 

Session Category: Experimental and Molecular Therapeutics
Authors: Liza Wijler, Jara Garcia, Muntaser Abdulrahman, Linda van Seters, My Nguyen, Annelot Staes, Bram Herpers, Leo Price, Marrit Putker

2980

HX009, a First-in-class PD1xCD47 BsAb, Demonstrated Anti-AML Activity in PDX Models

Session Date and Time:
Monday Apr 17, 2023 
1:30 PM - 5:00 PM 

Session Category: Immunology
Authors:  Annie An, Jingping Liu, Hang Ke, Steven Xiong, Xiaolong Tu, Lei Zhang, Faming Zhang, Henry Li

4146

Unlocking IO Drug Potential by High Content Imaging of Immune Cell Co-cultures with Cancer Organoids from Diverse Cancer Indications

Session Date and Time:
Tuesday Apr 18, 2023 
09:00 AM - 12:30 PM 

Session Category: Immunology
Authors: Saskia de Man, Chiara Foini, Tomas Veenendaal, Michelle Klop, Christos Sarantaris, Sergei Chavez Abiega, Nataliia Beztsinna, Daniel Okkes, Ashgard Weterings, Leo Price, Gera Goverse

4168

BALB/c-CD3EDG HuGEMM™ Mouse Model for Evaluation of CD3-targeted Tumor Immunotherapy

Session Date and Time:
Tuesday Apr 18, 2023 
09:00 AM - 12:30 PM 

Session Category: Immunology
Authors: Demi X. Liu, Kaixia Lian, Xuefei Yan, Jie Lin, Xiaoxi Xu, Annie Xiaoyu An, Ludovic Bourre, Jessie JingJing Wang

4570

Expanding the 3D Ex Vivo Patient Tissue Platform Toolbox for Immuno-Oncology Drug Testing

Session Date and Time:
Tuesday Apr 18, 2023 
1:30 PM - 5:00 PM 

Session Category: Tumor Biology
Authors: Nataliia Beztsinna, Sander Basten, Ezgi Kaya Aksoy, Niels Meesters, Stefanos Timiliotis, Donny van der Meer, Kuan Yan, Emma Spanjaard, Willemijn Vader, Leo Price

4679

Molecular Pathology and BTKi Pharmacology of DLBCL PDX Models

Session Date and Time:
Tuesday Apr 18, 2023 
1:30 PM - 5:00 PM 

Session Category: Tumor Biology
Authors: Jingjing Wang, Yueying Wang, Wubin Qian, Jia Xue, Sheng Guo, Likun Zhang, Henry Li

5118

STING Agonist and TLR7/8 Agonist Overcome Anti-PD-1 Resistance Mediated by Loss of β2M

Session Date and Time:
Tuesday Apr 18, 2023 
1:30 PM - 5:00 PM 

Session Category: Immunology
Authors: Aaron Li Hua, Chenpan Nie, Jie Lin, Annie Xiaoyu An, Ludovic Bourre, Jessie JingJing Wang

5133

Evaluation of an Anti-huIL4Rα mAb in the OXA-Induced Atopic Dermatitis Model in hIL4/hIL4α Double-KI (C57BL/6) Mice

Session Date and Time:
Tuesday Apr 18, 2023 
1:30 PM - 5:00 PM 

Session Category: Immunology
Authors: Tao Yang, Rongfei Lu, Xiaofei Xu, Likun Zhang, Dawei Wang, Xinhe Feng, Xiaoyu An, Jessie (Jingjing) Wang, Carl Edwards III

5134

PD-1/PD-L1 Signaling Axis, “A Double-edged Sword” in a DSS-Induced Colitis Mouse Model

Session Date and Time:
Tuesday Apr 18, 2023 
1:30 PM - 5:00 PM 

Session Category: Immunology
Authors: Tao Yang, Rongfei Lu, Kaixia Lian, Likun Zhang, Dawei Wang, Xinhe Feng, Xiaoyu An, Jessie (Jingjing) Wang, Carl Edwards III

6592

An AI Platform for Vascular and Fibrosis Analysis of Pathology Images

Session Date and Time:
Wednesday Apr 19, 2023 
9:00 AM - 12:30 PM 

Session Category: Bioinformatics / Computational Biology / Systems Biology / Convergent Science
Authors: Yawen Zheng, Dawei Wang, Likun Zhang, Sheng Guo

6775

Indivumed Services - Combination of Spatial Transcriptomics and Multiplex IHC as Valuable Multi-Omics Tool for Biomarker Discovery

Session Category: Biomarkers
Authors: Nicole Kerstedt, Monika Schoeppler, Bita Motamedi-Baniassad, Antonia Hirt, Julia Ploetzky, Mirja Kastein, Laura Thoms, Malik Khenkhar, Hartmut Juhl, and Kerstin A. David

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