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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Resources

Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Blogs

Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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AACR 2023 Posters

29

Characterization of a Murine Intestinal Cancer Homograft Model for Therapeutic Evaluation

Session Category: Tumor Biology
Authors: Jinxi Wang, Leilei Chen, Likun Zhang, Jingqian Zhu, Ludovic Bourre, Jessie J.J. Wang

52

Characterization of Murine Intrahepatic Cholangiocarcinoma Homograft Models for Therapeutic Evaluation

Session Category: Tumor Biology
Authors: Jinxi Wang, Leilei Chen, Likun Zhang, Lei Zheng, Ludovic Bourre, Jessie J.J. Wang

185

Global Mapping of Pathway Modules and Phosphorylation Networks in PDX and Corresponding Organoid (PDXO) Models Treated with Targeted Therapies

Session Category: Tumor Biology
Authors: Martin Mehnert, Xiaoxi Xu, Tobias Treiber, Limei Shang, Leilei Chen, Jessie Wang, Marco Tognetti, Christopher Below, Roland Bruderer, Jakob Vowinckel, Binchen Mao, Wubin Qian, Sheng Guo, Ludovic Bourré, Yuehan Feng

198

Pan-cancer Assay-ready Organoid Drug Screening with Robust, Reproducible and Clinically-relevant Output 

Session Category: Tumor Biology
Authors: Liza Wijler, Jara Garcia Mateos, My Nguyen, Annelot Staes, Linda van Seters, Lama Hasan, Victor Tirouille, Bram Herpers, Leo Price, Mariusz Madej, Michiel Fokkelman, Marrit Putker

401

Developing KRAS G12C Inhibitor-resistant Tumor Models for Efficacy Evaluation of Next-generation Anticancer Therapies 

Session Category: Experimental and Molecular Therapeutics
Authors: Jun Zhou, Zi Ye, Dan Zhang, Aaron Hua, Chenpan Nie, Jessie (Jingjing) Wang, Rajendra Kumari, Leo Price, Xiaoxi Xu

497

HX301, a First-in-class ARK5i, Demonstrates Antitumor Activity in Preclinical HCC Models with High ARK5/Myc Expression

Session Category: Experimental and Molecular Therapeutics

Authors: Zhihua Jiao, Jessie Wang, Hang Ke, Faming Zhang, and Henry Li

579

Mini-tumors: Preclinical HCI Assays to Screen Anti-cancer Drugs in the Context of Organoids, Cancer-associated Fibroblasts and Immune Cells 

Session Category: Experimental and Molecular Therapeutics

Authors: Marten Hornsveld, Guusje Odenkirchen, Cyrelle van Dort, Jara Garcia, Saskia de Man, Gera Goverse, Bram Herpers, Mariusz Madej, Leo Price, Marrit Putker

2053

Structural Variants Detected by Optical Genome Mapping in Acute Lymphoblastic Leukemia Patient-Derived Xenograft Models

Session Category: Bioinformatics / Computational Biology / Systems Biology / Convergent Science
Authors: Yueying Wang, Mengting Qing, Jinping Liu, Xiaobo Chen, Jia Xue, Sheng Guo

2387

Characterization of Orthotopic Bioluminescent Patient-derived Xenografts Model of Glioma for Drug Discovery

Session Category: Tumor Biology
Authors: Jinxi Wang, Ling Chen, Jun Zhou, Likun Zhang, Jinyu Huang, Xueluan Zhu, Ludovic Bourre, Jessie J.J. Wang

2822

Maximizing Radiotherapy Impact: A Novel Preclinical Platform for Screening of Radiosensitizing Agents in Patient-derived Tumor Organoids

Session Category: Experimental and Molecular Therapeutics
Authors: Liza Wijler, Jara Garcia, Muntaser Abdulrahman, Linda van Seters, My Nguyen, Annelot Staes, Bram Herpers, Leo Price, Marrit Putker

2980

HX009, a First-in-class PD1xCD47 BsAb, Demonstrated Anti-AML Activity in PDX Models

Session Category: Immunology
Authors:  Annie An, Jingping Liu, Hang Ke, Steven Xiong, Xiaolong Tu, Lei Zhang, Faming Zhang, Henry Li

4146

Unlocking IO Drug Potential by High Content Imaging of Immune Cell Co-cultures with Cancer Organoids from Diverse Cancer Indications

Session Category: Immunology
Authors: Saskia de Man, Chiara Foini, Tomas Veenendaal, Michelle Klop, Christos Sarantaris, Sergei Chavez Abiega, Nataliia Beztsinna, Daniel Okkes, Ashgard Weterings, Leo Price, Gera Goverse

4168

BALB/c-CD3EDG HuGEMM™ Mouse Model for Evaluation of CD3-targeted Tumor Immunotherapy

Session Category: Immunology
Authors: Demi X. Liu, Kaixia Lian, Xuefei Yan, Jie Lin, Xiaoxi Xu, Annie Xiaoyu An, Ludovic Bourre, Jessie JingJing Wang

4570

Expanding the 3D Ex Vivo Patient Tissue Platform Toolbox for Immuno-Oncology Drug Testing

Session Category: Tumor Biology
Authors: Nataliia Beztsinna, Sander Basten, Ezgi Kaya Aksoy, Niels Meesters, Stefanos Timiliotis, Donny van der Meer, Kuan Yan, Emma Spanjaard, Willemijn Vader, Leo Price

4679

Molecular Pathology and BTKi Pharmacology of DLBCL PDX Models

Session Category: Tumor Biology
Authors: Jingjing Wang, Yueying Wang, Wubin Qian, Jia Xue, Sheng Guo, Likun Zhang, Henry Li

5118

STING Agonist and TLR7/8 Agonist Overcome Anti-PD-1 Resistance Mediated by Loss of β2M

Session Category: Immunology
Authors: Aaron Li Hua, Chenpan Nie, Jie Lin, Annie Xiaoyu An, Ludovic Bourre, Jessie JingJing Wang

6592

An AI Platform for Vascular and Fibrosis Analysis of Pathology Images

Session Category: Bioinformatics / Computational Biology / Systems Biology / Convergent Science
Authors: Yawen Zheng, Dawei Wang, Likun Zhang, Sheng Guo

6775

Indivumed Services - Combination of Spatial Transcriptomics and Multiplex IHC as Valuable Multi-Omics Tool for Biomarker Discovery

Session Category: Biomarkers
Authors: Nicole Kerstedt, Monika Schoeppler, Bita Motamedi-Baniassad, Antonia Hirt, Julia Ploetzky, Mirja Kastein, Laura Thoms, Malik Khenkhar, Hartmut Juhl, and Kerstin A. David

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