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AACR 2023 Poster 29

Characterization of a Murine Intestinal Cancer Homograft Model for Therapeutic Evaluation

Jinxi Wang1, Leilei Chen1, Likun Zhang1, Annie An1, Ruilin Sun2, Jingqian Zhu1, Lei Zheng1, Jiajia Zhu1, Ludovic Bourre1, Jessie J.J. Wang1

1Crown Bioscience Inc., 16550 West Bernardo Drive, Building 5, Suite 525, San Diego, CA 92127
2Shanghai Model Organisms Center, Inc. (SMOC)

Gastrointestinal tract cancers are responsible for over one quarter of the cancer incidence (26%) and over one third (35%) of all cancer-related deaths. Therefore, the development of clinically relevant animal models recapitulating key molecular mechanisms and pathophysiological features is needed. Genetically engineered mouse models (GEMMs) with dysfunctional DNA mismatch repair (MMR) genes, like MLH1 and MSH2, manifest intestinal tumors related to microsatellite instability (MSI). In this study, a murine intestinal cancer homograft from GEMMs with MMR deficiency is established to enroll larger cohorts of mice in a synchronized manner for preclinical studies.

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  • Methods for generating MLH1-KO mouse using CRISPR/Cas9 engineering

  • Tumor development in MLH1-KO GEMM mice and characterization of an intestinal tumor homograft, mCR9105

  • In Vivo efficacy results of model mCR9105

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