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AACR 2023 Poster 52

Characterization of Murine Intrahepatic Cholangiocarcinoma Homograft Models for Therapeutic Evaluation

Jinxi Wang1, Leilei Chen1, Likun Zhang1, Ruilin Sun2, Jingqian Zhu1, Lei Zheng1, Ludovic Bourre1, Jessie J.J. Wang1

1Crown Bioscience Inc., 16550 West Bernardo Drive, Building 5, Suite 525, San Diego, CA 92127
2Shanghai Model Organisms Center, Inc. (SMOC), 178 Banxia Road, Pudong New Area, Shanghai

Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive adenocarcinoma derived from bile ducts within the liver and establishing suitable animal models for in vivo investigation of oncology and immuno-oncology treatment strategies for iCCA is critical. In this study, genetically engineered mouse models (GEMMs) were established with liver-specific KrasG12D/+ and Ptennull mutations and successfully induced development of iCCA liver lesions with glandular morphology in C57BL/6 mice. Although the incidence rate of iCCA in this GEMM reached almost 100%, there are some limitations. This can be circumvented by using tumor homograft models combining the benefits of GEMM with an improved operational simplicity, consistency and growth.

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  • Strategy for generating GEMM with spontaneous iCCA and tumor homograft model

  • Advantages of using tumor homograft models and combining the benefits of GEMM models

  • Characterization data of  iCCA homograft models, derived from different iCCA GEMM individuals

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