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AACR 2022 Poster 2059

Immunotherapy Testing in 3D Ex Vivo Patient Tissue Platform with Preserved Tumor Microenvironment

Nataliia Beztsinna1, Niels Meesters1, Fanny Grillet2, Donny van der Meer2, Lidia Daszkiewicz1, Kuan Yan1, Emma Spanjaard1, Willemijn Vader2 and Leo Price1
1 Crown Bioscience Netherlands, Leiden, The Netherlands, 2 VitroScan B.V. Leiden, The Netherlands

Extensive applications of immunotherapies to treat cancer patients has been hampered by low response rates in the clinic (about 20%)1 and high failure rates of clinical trials (about 90%)2. One of the underlying reasons is a lack of translational preclinical models that accurately replicate human immunological complexity. Even the most advanced 3D in vitro models, such as patient-derived organoids, are still lacking the innate immune components of the tumor microenvironment (TME).

This poster presents a novel 3D Ex Vivo Patient Tissue Platform that combines a short-term 3D ex vivo tumor culture system with high content image (HCI)-based analysis.

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  • Successfully combined immunotherapy testing protocols using fresh patient tumor tissue with preserved TME components and advanced 3D HCI analysis.

  • Rapid, reliable and patient-relevant approach to test immunotherapies, including checkpoint inhibitors, for different solid tumor types.

  • The potential to significantly improve the preclinical evaluation of immunotherapies and support the decision-making process during progression of drug candidates to the clinic.

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