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Publication: Using MCT to Identify EGFR Predictive Biomarker in ESCC

Zhu H*#, Wang C*#, Wang J, Chen D, Deng J*#, Deng J, Fan J^, Badakhshi H§, Huang X, Zhang L, Cai J, Guo S, Qian W, Nie Y$, Li Q, Zhao K*#.
A subset of esophageal squamous cell carcinoma patient-derived xenografts respond to cetuximab, which is predicted by high EGFR expression and amplification
J Thorac Dis 2018; 10(9):5328-38.

*Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University
#Department of Oncology, Shanghai Medical College, Fudan University
^Department of Gynaecology, Renhe Hospital
§Department of Radiation Oncology, Charité School of Medicine and Centre for Cancer Medicine
$State Key Laboratory of Cancer Biology & Xijing Hospital of Digest Diseases, Fourth Military Medical University

CrownBio 2018. Publication. Using MCT to Identify EGFR Predictive Biomarker in ESCCEpidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal tumors. However, non-selected patient cohorts have shown no response to most EGFR-targeted therapies.

Identifying which esophageal squamous cell carcinoma (ESCC) patients respond to EGFR targeting agents, and a predictive biomarker to stratify clinical cohorts for treatment, would help improve the poor prognosis in ESCC.

This publication investigates the activity of cetuximab in a Mouse Clinical Trial using a cohort of ESCC patient-derived xenograft (PDX) models. PDX have been previously used to predict clinical activity of drugs and explore biomarkers across a range of cancer types.

Download This Publication To Understand:

  • That ESCC PDX models recapitulate patient disease preclinically, allowing the investigation of translational biomarkers of response

  • How a Mouse Clinical Trial across a cohort of PDX models identified a subset of responders to cetuximab monotherapy

  • That gene amplification and expression analysis indicated that high EGFR copy number, high EGFR mRNA expression, and IHC score of 2–3 associate with cetuximab response, indicating EGFR may function as a single predictive biomarker for cetuximab response in ESCC

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