Reliable Clinical Chemistry and Biomarker Services


"CrownBio brings clarity to drug discovery around the world by helping biopharmaceutical companies solve some of today's most pressing problems in oncology, cardiovascular, and metabolic disease.

Leveraging our industry expertise, CrownBio's global resources help customers answer the most challenging questions about human biology. We begin with the end insight to help you achieve your goals"

Dr Jean-Pierre Wery
CEO, Crown Bioscience Inc.

Make Decisions with Confidence Early in Preclinical CVMD Research with CrownBio’s Reliable Clinical Chemistry and Biomarker Services

CrownBio offers clinical chemistry and biomarker services to provide robust, high quality data for the early preclinical development of CVMD drugs and diagnostics. Our expertise covers a range of models and therapeutic areas, with a particular focus on cardio-metabolic endpoints in rodents and non-human primates. CrownBio provides a rapid, cost effective way to analyze samples as a standalone service, or as a supplement to in vivo studies.

Non-GLP Clinical Chemistry and Biomarker Services

Analytes listed in the following sections are subject to change. Please contact your local business development specialist for our current offerings.

Clinical Chemistry Services

CrownBio can efficiently analyze the effects of agents through a comprehensive portfolio of clinical chemistry assays that provide valuable information about drug efficacy, candidate selection, and enzymatic activity. The following portfolio of assays were developed on the Beckman-Coulter AU480 Chemical System and are available through CrownBio as a service to help advance preclinical CVMD development programs:

View Assays
Alkaline Phosphate
Creatine Kinase
HbA1C - Glycosalated Hemaglobins
Lactate Dehydrogenase
T4 (Tyroxine)
Total Bilirubin
Total Protein
Uric Acid

Biomarker Services

Translational biomarkers are used throughout drug development to help elucidate underlying pathophysiology, understand agents’ mechanisms of action, measure efficacy, and stratify patient populations. CrownBio recognizes the importance of biomarkers from target validation studies to candidate selection and our scientists can develop, validate, and run custom assay services in addition to the following set of immunoassay services routinely performed to help inform decision making in CVMD development.

MesoScale Discovery Biomarker Services – electrochemiluminescent technology platform. These biomarkers can be customized into a V-PLEX or U-PLEX plate with up to 10 biomarkers of the client’s choice.

View MesoScale Discovery Assays


Rodent Assays
  • Mouse Adiponectin
  • Mouse IL-1b
  • Mouse IL-2
  • Mouse IL-4
  • Mouse IL-5
  • Mouse IL-6
  • Mouse IL-10
  • Mouse IL-12
  • Mouse KC/GRO
  • Mouse Leptin
  • Mouse MCP-1
  • Mouse RANTES
  • Mouse TNF-a
  • Mouse Metabolic Kit
    • (Insulin and Leptin)
  • Mouse Proinflammatory Panel 1,
    • (IFN-ץ, IL-1β, IL-2, IL-4, IL-5, IL-6, KC/GRO, IL-10, IL-12p70 and TNF-α)
  • Rat Adiponectin
  • Rat IL-1a
  • Rat IL-1b
  • Rat IL-4
  • Rat IL-5
  • Rat IL-6
  • Rat IL-13
  • Rat KC/GRO
  • Rat MCP-1
  • Rat MIP-3a
  • Rat Argutus AKI Test
    • (GSTYb1, RPA-1, αGST)
  • Rat Cardiac Injury Panel 2
    • (cTroponin T, cTroponin I, FABP3)
  • Rat Cardiac Injury Panel 3
    • (cTroponin T, FABP3, Myl3, cTroponin)
  • Rat Clusterin Kit
  • Rat Kidney Injury Panel 1
    • (Albumin, KIM-1, NGAL/LCN2, Osteopontin)
  • Rat Muscle Injury Panel 1
    • (cTroponin T, FABP3, sTroponin I, Myl3, cTroponin)
  • Rat Proinflammatory Panel 2
    • (IFN-γ, IL-4, IL-1β, IL-5, IL-6, KC/GRO, IL-10, IL-13, TNF-α)
  • Rat TIM-1/KIM-1/HAVCR Kit
  • Rat TNF-a
  • Mouse/Rat EPO, serum/plasma kit
  • Mouse/Rat GLP-1 (7-36 amide)
  • Mouse/Rat Glucagon
  • Mouse/Rat Insulin
  • Mouse/Rat Insulin/Glucagon
  • Mouse/Rat Resistin
  • Mouse/Rat Total Active GLP1, Insulin, Glucagon
  • Mouse/Rat Total GLP-1 (v2) (NHP)
  • Mouse/Rat VEGF, 20 plates
Nonhuman Primate (NHP) Assays
  • 4-Spot Prototype Human Insulin, C-Peptide for NHP
  • NHP Total GLP-1

ELISA Biomarker Assays – colorimetric and chemiluminescent technology platforms

View ELISA Assays


Rodent Assays
  • Mouse Albumin
  • Mouse MCP-1
  • Mouse VEGF-A
  • Rat Adiponectin
  • Rat Albumin
  • Rat IL-6
  • Rat C-peptide
  • Rat Growth Hormone
  • Rat Hydroxproline
  • Rat Parathyroid Hormone
  • Rat Pro-Insulin
  • Rat TNF-a
  • Rat VEGF-C
  • Mouse/Rat Corticosterone
  • Mouse/Rat Corticosterone Cayman
  • Mouse/Rat Leptin
  • Human/Rat/Mouse Glucagon ELISA
Human and NHP Assays
  • Human Cortisol
  • Human IGFBP-1 ELISA
  • Human Intact FGF21
  • Human/Rat/Mouse Glucagon ELISA
  • NHP Adiponectin
  • NHP Glucagon
  • NHP Cytokeratin-18
Other Species Assays
  • Porcine/Canine Insulin
Service Details
  • Turn Around Time: 5 to 7 business days
  • Data Delivery Format: Excel File, unless otherwise requested

Assay Validation

CrownBio recognizes the importance of providing reliable data to our clients, so we have instated rigorous quality control and assay qualification procedures to ensure precision and accuracy. We provide high quality results that our clients can trust when making go/no-go decisions in their CVMD preclinical research programs. Please see below for examples of standard curves generated for two important cytokines.

CrownBio’s custom-fit, 7-point standard curves used to calculate accurate and precise concentrations for IL-10 and TNF-α in client samples..