We provide syngeneic models of metastasis as well as orthotopic and bioluminescent models. This allows you to study clinically relevant metastatic invasion, metastatic lesions in secondary organs, and to evaluate your agents which target metastasis.
Breast: 4T-1 (metastatic/bioluminescent, orthotopic)
Liver: H22 (orthotopic/bioluminescent) Hepa 1-6 (orthotopic/bioluminescent)
Our orthotopic models provide a tumor microenvironment more comparable to the patient. The tumors form at organ-specific sites, facilitating metastatic spread, and supporting immune and stromal component interactions.
Our bioluminescent imaging (BLI) capabilities enable non-invasive longitudinal monitoring of orthotopic tumor burden. This provides you with optimal randomization, reduction of false positives, and continuous feedback, supporting the most appropriate treatment regimens mid-study.