In Vitro Services

Whatever your project needs, we have the in vitro
biology platform
to support faster, better decision-making

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Our In Vitro Services Include a Large Cohort of Validated and Well-Characterized Cell Lines

CrownBio offers a variety of in vitro platforms for your oncology drug discovery program.

At CrownBio we are committed to saving you precious time and resources by providing efficient screening platforms and validated cell lines, giving you confidence in your data.

Our large team of international scientists have extensive experience working with Pharmaceutical and Biotechnology companies to support the in vitro pharmacology characterization of lead compounds.

In vitro services laboratory work

Select from our Collections of Generic or Focused Cancer Cell Lines

  • OmniPanel™, a genomically diverse collection of more than 400 cancer cell lines for drug response screening

  • XenoSelect™, a diverse oncogenic in vitro screening panel of over 180 well-validated cell lines, with associated Cell Line Derived Xenograft models ready for in vivo efficacy studies

  • RNAseq Panel, more than 120 in-house genomically characterized cell lines to correlate mutation status, copy number variation, and expression levels with drug response

  • PrimePanel™, a unique collection of cancer cell lines with each primary cell originating from one of our genetically defined HuPrime® Patient-Derived Xenograft (PDX) models

Our characterized cell line panels can be used in OmniScreen™, our global program of high throughput cell based screens for target expansion, lead finding, and lead optimization projects.

A Comprehensive Range of Functional Assays

CrownBio’s extensive tool sets to determine the biological functions of each target, and to help you take go/no go decisions, include a variety of functional assays such as:

  • High throughput cytotoxicity screening
  • In vitro drug combination studies
  • 3D clonogenic assays
  • 3D Tumor Growth Assays using PrimePanel cell lines
  • Target validation studies
  • Adhesion, migration, and invasion assays
  • Angiogenesis assays
  • Apoptosis studies
  • ADCC and CDC analyses
  • Cell cycle analysis
  • Pharmacodynamics/Pharmacokinetics analysis

Immuno-Oncology In Vitro Screening

Cancer immunotherapy is coming of age as a treatment paradigm, however, development of new immunotherapeutics still faces many challenges. Testing new immuno-oncology compounds in vitro, before moving to the in vivo setting, has proved challenging for many new drugs such as biological agents.

CrownBio offers a wide range of assays and platforms for in vitro testing of immuno-oncology agents, including core immunophenotyping, functional assays, and technologies for the regulation of the tumor microenvironment, allowing you to move with confidence to the next phase of drug development.

Contact us today for free expert advice to support all of your in vitro drug discovery needs.

Quick Facts

Posters

  • AACR 2015 1038 - Cell-based Screening Identifes Gene Expression Signature Correlated with Sensitivity to PI3KmTOR Dual Inhibitor BEZ235
  • AACR 2014 3440 - Cell-based Screening Identifies Gene Expression Signature Correlated with Sensitivity to MEK Inhibitor Trametinib

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