Evaluate How Novel Cancer Therapies Perform in Models with a Functional Immune System
Immunotherapeutics fight cancer by taking advantage of a patient’s own immune system, therefore, preclinical research into new therapies requires appropriate models with fully functional immunity.
Syngeneic tumor models (allografts derived from immortalized mouse cancer cell lines which originated from the same inbred strain of mice) provide a valuable system for assessing new single agent and combination immunotherapies within mice with fully competent immunity.
CrownBio provides a panel of well validated syngeneic mouse models for preclinical immunotherapy research, with full immune cell profiling via FACS, RNAseq data, and treatment data available including a range of checkpoint inhibitors. Our suite of syngeneic models includes nearly 20 cancer types, with over 30 models available or in development.
Standard and Bioluminescent Syngeneic Models to Meet a Range of Research Needs
Our standard syngeneic models are used to interrogate novel immune treatments with panels of our syngeneic models utilized in checkpoint inhibitor evaluation. We also provide orthotopic syngeneic models of metastasis, including bioluminescent models, allowing clients to study clinically relevant metastatic invasion, metastatic lesions in secondary organs, and the evaluation of agents to target this metastasis.
Selection of the appropriate syngeneic tumor models of interest is made easy by our curated online murine cancer model database MuBase®, and our powerful new search engine (which searches models from all our Oncology databases) OncoExpress™.
Introducing the First Large-Scale In Vivo Screening Platform for Immunotherapeutics
CrownBio has made the decision making process easy to fast-track your novel immunotherapeutics in MuScreen™, the first large-scale, staggered, in vivo screening platform for cancer immuno- oncology agents. MuScreen is used to rapidly focus immuno-oncology research efforts such as screening for efficacy, identifying PD markers, evaluating combination therapies, and qualifying drug resistance.
We provide three fixed sets of MuScreen syngeneic tumor models:
- Efficacy Screening Panel
- PD Screening Panel
- Tumor Microarrays
Our Syngeneic Efficacy and PD Screening Panels run following a preset schedule, with fixed panels of 12 or 20 models and a shared vehicle group. The main endpoints are TGI (with optional FACS and IHC) for Efficacy, and FACS analysis of tumor infiltrating lymphocytes and tumor associated macrophages for PD, which can be concurrently evaluated.
Benefits of a MuScreen
- Providing an effective and accurate way to find the right model/right PD effect - particularly for combination studies, where choosing a model that shows intermediate response to single agent treatment is key
- Large-scale screening to reduce variability
- Improving efficiency and saving study time by quickly identifying markers or models to progress to the next stage
- Improving cost-effectiveness by client sharing of vehicle and other common groups
Contact us today for more information on our syngeneic tumor models, or to enroll your compounds onto the next MuScreen.