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Brain Cancer PDX Models

Suitable preclinical models are needed to evaluate therapies targeting specific pathways which affect brain cancer. Patient-derived xenograft (PDX) models are known to closely reflect human heterogeneity and provide the most accurate approach to predicting an agent’s efficacy prior to entering the clinic. The Crown Bioscience brain cancer PDX collection consists of a wide range of models, including several orthotopic models to more closely recapitulate the tumor microenvironment. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience's HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER SUBTYPE # per page
BN0769 Meningeoma CLICK TO VIEW
BN10438 GBM CLICK TO VIEW
BN13331 Meningeoma CLICK TO VIEW
BN15385 GBM CLICK TO VIEW
BN2276 GBM CLICK TO VIEW
BN2287 Glioma CLICK TO VIEW
BN2289 Glioma CLICK TO VIEW
BN2331 Glioma CLICK TO VIEW
BN2338 Glioma CLICK TO VIEW
BN3733 GBM CLICK TO VIEW
BN3801 NA CLICK TO VIEW
BN4027 Glioma CLICK TO VIEW
BN4045 GBM CLICK TO VIEW
BN5457 NA CLICK TO VIEW
BN5459 NA CLICK TO VIEW
BN5463 NA CLICK TO VIEW
BN5474 Glioblastoma CLICK TO VIEW
BN6299 Glioma CLICK TO VIEW
BN6300 Astrocytoma CLICK TO VIEW
BN6303 Glioma CLICK TO VIEW
BN6304 Astrocytoma CLICK TO VIEW
BN9224 GBM CLICK TO VIEW

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