Quickly Find Models to Fit Your Research Needs
Understanding the genetic drivers behind tumorigenesis is critical for the development of cancer therapeutics. Scientists at CrownBio have deployed the latest genomic characterization technologies to understand the genetic background of a wide range of our models, covering:
- Cell lines and their associated ValidatedXeno™ xenografts
- HuPrime® Patient-Derived Xenograft (PDX) models
- Tumor organoid models, developed using best-in class Hubrecht Organoid Technology (HUB) protocols
- Our standard and novel immunotherapy platforms
Collating all of these data in our easy to use online databases and model search engine provides a fast and uncomplicated method for our clients to understand the comprehensive genetic context behind the response to their compounds, and to find models to fit their further research needs.
|mRNA expression||microRNA expression||copy number||mutations|
|gene fusion||clinical data||pharmacology data|
Simplify your model selection using the only online database collating mutational and gene expression profiles for tumor organoid models.
OrganoidBase currently features data for our PDX-derived tumor organoid models from more than 10 different cancer indications. HUB patient-derived tumor organoids data will be available soon.
Online database containing information for CrownBio’s immuno-oncology murine efficacy platforms:
- Syngeneic tumor models
- Murine homograft models, MuPrime
- Humanized HuGEMM mouse models.
MuBase provides the ability to search and browse the genomic, proteomic, and pharmacological profiles completed for these models to help identify the most suitable models for your studies.
- Public profiling data
- expression, copy number, and mutation
- Proprietary pharmacology data
Linked and searchable for you to easily find and navigate to models that match your criteria.
OncoExpress is our newly launched search engine allowing clients to explore all CrownBio models contained in HuBase, XenoBase, and MuBase, in just one search. OncoExpress also includes model information such as growth curves, standard of care pharmacological data, mutation, and copy number analysis.
More complete model information is found within each individual database, however, OncoExpress provides a rapid way to comprehensively search throughout CrownBio assets to find all relevant models across multiple platform types.
Click the links at the top of the page to register for access to our databases and OncoExpress to discover models that fit your needs.