AACR 2024 Poster LB435

Large Panel Organoid Drug Testing Combined with Biomarker Analysis: Unveiling Prospects for Mechanism of Action Identification and Preclinical Patient Stratification

Linda Xue, Liza Wijlers, Marten Hornsveld, Sheng Guo, Leo Price, Marrit Putker, Ludovic Bourre

Addressing the high attrition rate in oncology drug development, our study showcases a large-scale proof-of-concept organoid experiment. By evaluating 50 organoid models' responses to paclitaxel, this research leverages next-generation sequencing to dissect the drug's mechanism of action and unearth biomarkers predicting drug responses. This novel approach exemplifies how assay-ready organoid technology can enhance the precision of preclinical drug testing, offering insights into drug action mechanisms and improving the prediction of clinical outcomes.

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• Innovative organoid screening that combines patient-derived models with biomarker discovery.
• Key genetic markers distinguishing drug response, enabling personalized therapy approaches.
• Crucial insights into paclitaxel’s action and resistance mechanisms through pathway analysis.

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