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The Increased Odds of Developing Diabetes

Due to increasing obesity levels, inactivity, and an aging population worldwide the prevalence of type 2 diabetes has reached epidemic proportions. The World Health Organization reports that 347 million people globally have diabetes, with type 2 accounting for 90% of cases. Whilst type 2 diabetes prevalence rates have been increasing in the US recently, (from… Read more »

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Merck First Past the US Post in Anti-PD-1 Therapies

Immunotherapy is at the forefront of oncology research, with many companies focusing on the same specific targets in multiple cancer types. The race has been on for the first US approval of an anti-PD-1 agent, and Merck have proved victorious with the FDA saying yes to Keytruda (pembrolizumab) in advanced melanoma just last week.

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Energizing the Immune System in Glioblastoma Treatment

Historically in oncology, the therapeutic use of radiation has been based on its ability to kill cells and selectively target tumor tissue. More recently a paradigm shift has been seen – combining radiotherapy with up and coming immunotherapies to exploit the benefits of each treatment and extend patient survival. Recent preclinical research in this area… Read more »

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Find the Right Way to use PDX in Personalized Medicine Research

Personalized medicine is the future of cancer therapy, and many techniques are being used to drive forward research in this area. Patient-derived xenograft (PDX) models are at the forefront of personalized medicine research in human surrogate trials, but other approaches to using PDX are also being pioneered which may not bring the full patient benefit… Read more »

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An Old Need for New Therapies in CLL

Chronic lymphocytic leukemia (CLL) is a cancer type mainly seen in elderly people, with the average age of diagnosis being 72 years old. However, elderly patients have been underrepresented in CLL clinical trials, and the current gold standard treatment of chemoimmunotherapy is only viable for physically fit people under 65, which rules out the majority… Read more »