3D glasses

Put Your Glasses On, Tumor Pharmacology Goes 3D

Attrition rates in oncology drug development are higher than in other disease areas, with almost 95% of compounds showing preclinical activity failing to reach clinical development. This indicates a disconnect between current preclinical models and tumors in patients. CrownBio, in collaboration with the University of Nottingham, has recently developed a system for growing patient-derived tumor… Read more »

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Study Finds Perfect Therapeutic Match To Fight a Common Form of Leukemia

Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer, characterized by an excessive production of immature white blood cells (lymphoblasts) by the bone marrow. Although most children survive ALL, many suffer late or long-term side effects from treatment, including heart problems, growth and development delays, secondary cancers, and infertility. Now researchers at… Read more »

warming up

Warming up the Issue of Heat Loss

Obesity was classified as a disease by the American Medical Association in 2013, and has become a serious epidemic issue in many developed and developing countries. Global obesity levels have more than doubled since 1980, with more than 600 million adults classified as obese in 2014. It is commonly believed that carrying excessive body fat… Read more »

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Cancer Cell Lines: Immortal Champions in Oncology Drug Discovery

Human cancer cell lines are a powerful model system that can be propagated virtually indefinitely in culture, and manipulated to assess sensitivity to anticancer drugs or to investigate the molecular factors behind response to therapy. Oncology research using cancer cell lines has provided meaningful insights into many aspects of cancer susceptibility to treatment and into… Read more »