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Model Information:

This strain carries a conditional mutant Kras (KrasLSL-G12D/WT) and a constitutive deletion of Trp53 (p53KO/KO). G12D mutant Kras was activated upon injecting adeno-cre directly to the pancreas at 6 weeks of age, which resulted in a pancreatic tumor 8 weeks later. This result is similar to previous reports with similar models, including a Pdx1-Cre; KrasLSL-G12D/WT; p53KO/KO model (http://www.ncbi.nlm.nih.gov/pubmed/24305049) and a iKras; p53loxp/loxp model (http://www.ncbi.nlm.nih.gov/pubmed/22541435).
Cancer Type Pancreatic Cancer
Mutations KRAS (G12D); P53-/-
Biopsy Site Pancreases
Pathology QC High grade spindle cell sarcoma (P0), poorly differentiated squamous cell carcinoma (P3)
Mouse Strain C57BL/6

Growth Characteristics

Additional Characteristics

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