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huPD-1/CTLA-4

Model Information:

The huPD-1/CTLA-4 model is a valuable tool for studying immune checkpoint pathways and their modulation in cancer research. This model features the introduction of human PD-1 and CTLA-4 genes into the C57BL/6 mouse strain, enabling the investigation of their expression and function in an in vivo setting.

Key Features:

Cancer Type: N/A Type: Double Knock-In Target: Human PD-1/CTLA-4 Mouse Strain: C57BL/6 Validation of Human Target Expression
The huPD-1/CTLA-4 model is designed to mimic the expression and interaction of human PD-1 and CTLA-4 immune checkpoint molecules. By introducing these human genes into the C57BL/6 mouse strain, researchers can study the effects of human PD-1 and CTLA-4 on immune responses, tumor development, and potential therapeutic interventions. The model undergoes thorough validation to ensure the appropriate expression of human targets, providing researchers with a reliable platform for studying immune checkpoint blockade and exploring novel treatment approaches.
Summary  
Cancer Type N/A
Type Double Knock-In
Target Human PD-1/CTLA4
Mouse Strain C57BL/6

Validation of Human Target Expression

Additional Characteristics

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