eBook

From Bench to IND: Critical DMPK and Toxicology Insights for Oncology Teams

Oncology programs face some of the highest attrition rates in drug development, often because critical liabilities in drug metabolism, pharmacokinetics, or safety are identified too late in the process. 

Strengthening IND submissions requires integrating drug metabolism, pharmacokinetics, and toxicology early and strategically. 

This eBook provides oncology researchers with practical frameworks to de-risk programs and accelerate development. Use the actionable strategies to anticipate and overcome common challenges.

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Download this eBook to Discover:

• Early risk detection frameworks: Learn how to identify ADME/DMPK red flags during discovery to prevent costly failures downstream.
  
  
• Predictive toxicology approaches: See how advanced in vitro and in vivo models, including translational systems, can reveal safety risks sooner and with greater accuracy.
  
  
• Data integration strategies: Discover best practices for combining pharmacokinetics, metabolism, and toxicology data to generate regulator-ready IND submissions.
  
  
• Regulatory alignment insights: Understand current expectations from health authorities and how to design studies that withstand scrutiny.
  
  
• Practical oncology applications: Explore case examples and emerging models that are particularly relevant to oncology drug development, where attrition rates remain highest.

De-risk your oncology pipeline before IND submission

DMPK and toxicology are not regulatory checkboxes - they are strategic levers that define whether oncology candidates succeed or fail. This eBook equips your team with practical strategies, model selection guidance, and regulatory considerations to strengthen decision-making from discovery through IND.

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