SITC 2023 Poster 549

Multiomics Biomarker Analysis in 12 Mouse Syngeneic Models Under ICI Treatment

Binchen Mao, Sheng Guo

Crown Bioscience, Inc., 218 Xinghu Street, Suzhou, Jiangsu, 215000, China

In the rapidly evolving field of immunotherapies, understanding tumor-immune interactions is paramount. Syngeneic mouse models, for this purpose, have become indispensable. Combining such models with the power of multiomics analysis reveals intricate details about potential biomarkers and treatment targets. In our current poster, we venture into a comprehensive multiomics biomarker exploration in 12 mouse syngeneic models to shed light on the markers pivotal for immunotherapy success.

Download this Poster to Discover:

• Insights on the effectiveness of ICI treatments in 'hot' versus 'cold' tumor microenvironments.
  
  
• The significant role of Dnmt3a as an ICI resistance biomarker and its implications in DNA methylation dynamics.
  
  
• How multiomics factor analysis can be instrumental in identifying pathways central to ICI response.

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