Xiaobo Chen, Jia Xue, Henry Q. Li and Sheng Guo
Cancer is a heterogeneous disease, which is highly related to the immune system. With the advance of immunotherapeutics, it’s important to fully understand interactions between cancer and immunity, to correctly predict which patients will respond to specific immuno-oncology (I/O) agents.
This also needs to be implemented across the range of murine models used as preclinical I/O study systems. NGS enables in-depth interrogation of the tumor-immune interactions at the gene expression and pathway levels, providing an efficient and robust method to systematically profile and characterize preclinical murine models.
This poster details the development of an I/O NGS panel to characterize murine model tumor-immune interactions for preclinical studies.