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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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On Demand Webinar

Shifting the Paradigm of Cancer Treatment: How Can Optical Imaging Help?

Shifting the Paradigm of Cancer Treatment: How Can Optical Imaging Help?

Cancer treatment has undergone a recent paradigm shift, first towards targeted and then immuno-oncology agents. Current treatment strategies combine a range of different therapies, and drug developers are continually looking for more relevant preclinical models to address the key questions they are facing.

Optical imaging provides unique, well-characterized and robust models to improve the predictive power of preclinical studies, allowing more efficient and cost-effective translation into the clinic. In this webinar, Dr Yinfei Yin discusses the value of optical imaging models in preclinical oncology research, with an emphasis on immunotherapy development. He also highlights the key new imaging models developed for evaluating novel anticancer agents.

Watch this Webinar to:

  • Explore the advantages of orthotopic syngeneic models, including organ-specific tumor microenvironments, development of relevant tumor vasculature, and stromal interactions
  • Understand the difference between orthotopic and subcutaneous syngeneic models in their response to checkpoint inhibitors
  • Discover how optical imaging allows real-time monitoring of tumor burden and tracking of disease progression, including for deep lying organs such as brain, prostate, and liver
  • Explore the insights bioluminescent imaging provides on disease mechanisms, as well as treatment of tumorigenesis and metastasis
  • Learn about unique imaging models, including engineered models and tumor homografts, engineered models to expand syngeneic tumor sources

Who Should Watch:

  • Oncology program leaders who want to maximize the translatability of their immuno-oncology preclinical studies
  • Scientists interested in staying up to date on in vivo imaging and how imaging is used to assess immunotherapy efficacy and compound mechanism of action
  • Researchers looking to understand how in vivo models, partnered with bioluminescent imaging, can be used to interrogate I/O drug mechanism of action and TME

Watch Now!


About The Presenter:

Dr Yinfei YinDr Yinfei Yin leads the Scientific Operations team at Crown Bioscience’s UK site and is also the head of Crown Bioscience’s Global Imaging Platform. In these roles, Yinfei has developed a wide range of in vivo models such as metastasis, orthotopic, and traditional subcutaneous models, to support key client decisions and successful drug discovery programs.

Prior to joining Crown Bioscience, Yinfei worked at the University of Nottingham’s Ex Vivo Cancer Pharmacology Centre of Excellence in the development of a bioluminescence and fluorescence-aided pharmaceutical candidate validation platform. Yinfei received his PhD from the University of Nottingham working on the role of Helicobacter pylori-stimulated EGF receptor in cancer invasion and metastasis.



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